Gut microbiota and vascular biomarkers in patients without clinical cardiovascular diseases

Daria Kashtanova; Olga Tkacheva; Anna Popenko; Lilit Egshatyan; Alexander Tyakht; Dmitry Alexeev; Yulia Kotovskaya; Ekaterina Plokhova; Sergey Boytsov

doi:10.1016/j.artres.2017.02.007

<Previous Article In Issue

Next Article In Issue>

Volume 18, Issue C, June 2017, Pages 41 - 48

Gut microbiota and vascular biomarkers in patients without clinical cardiovascular diseases

Authors

Daria Kashtanova^a^{, c}^{, *}^{, 1}, Olga Tkacheva^c^{, 2}, Anna Popenko^b^{, 4}, Lilit Egshatyan^d^{, 3}, Alexander Tyakht^b^{, 5}, Dmitry Alexeev^f, Yulia Kotovskaya^c^{, e}^{, 6}, Ekaterina Plokhova^c^{, 7}, Sergey Boytsov^a^{, 8}

^aNational Research Centre for Preventive Medicine, Moscow, Russian Federation

^bInstitute for Physical-Chemical Medicine, Moscow, Russian Federation

^cPirogov Russian National Research Medical University, Russian Clinical Research Center for Gerontology, Moscow, Russian Federation

^dFederal State Budgetary Establishment Endocrinology Research Centre, Russian Federation

^eRUDN-University, Moscow, Russian Federation

^fComplex Biological Systems Lab, Moscow Institute of Physics and Technology (State University), 9 Institutskiy per., Dolgoprudny, Moscow Region, 141700, Russian Federation

¹

Russian Clinical Research Center for Gerontology, Pirogov Russian National Research Medical University, bld. 16, 1st Leonova Street, Moscow, 129226, Russian Federation.

²

Russian Clinical Research Center for Gerontology, bld. 16, 1st 15 Leonova Street, Moscow, 129226, Russian Federation.

³

Federal State Budgetary Establishment Endocrinology Research Centre, Moscow.

⁴

Laboratory of Bioinformatics, Scientific Research Institute for Physical-Chemical Medicine, bld. 1a, Malaya Pirogovskaya St, Moscow, 119435, Russian Federation.

⁵

Laboratory of Bioinformatics, Scientific Research Institute for Physical-Chemical Medicine, bld. 1a, Malaya Pirogovskaya St, 119435, Moscow, Russian Federation.

⁶

Department of Cardiology and Personified Medicine, RUDN-University, 6 Miklukho-Maklaya St., Moscow, Russian Federation, Laboratory of Cardiovascular Ageing, Russian Clinical Research Center for Gerontology, Pirogov Russian National Research Medical University, bld. 16, 1st Leonova Street, Moscow, 129226, Russian Federation.

⁷

“Research of Age and Age-associated Conditions” Department, National Research Centre for Preventive Medicine, bld. 10, Petroverigskiy Lane, Moscow, 101000, Russian Federation.

⁸

Department of Cardiology and Molecular Genetics, National Research Centre for Preventive Medicine, bld. 10, Petroverigskiy Lane, Moscow, 101000, Russian Federation.

^*Corresponding author. “Research of Age and Age-associated Conditions” Department, National Research Centre for Preventive Medicine, bld. 10, Petroverigskiy Lane, Moscow, 101000, Russian Federation. E-mail addresses: dr.kashtanova@gmail.com (D. Kashtanova), Tkacheva@rambler.ru (O. Tkacheva), a.s.popenko@niifhm.ru (A. Popenko), lilit.egshatyan@yandex.ru (L. Egshatyan), at@niifhm.ru (A. Tyakht), exappeal@gmail.com (D. Alexeev), kotovskaya@bk.ru (Y. Kotovskaya), evplokhova@gmail.com (E. Plokhova), prof-boytsov@mail.ru (S. Boytsov).

Corresponding Author

Daria Kashtanova

Received 30 September 2016, Accepted 28 February 2017, Available Online 21 March 2017.

DOI: 10.1016/j.artres.2017.02.007 How to use a DOI?
Keywords: Gut microbiota; Arterial stiffness; Atherosclerosis; Low-grade inflammation
Abstract: The aim of this research was to study the association between the gut microbiota composition and arterial wall properties. The study included 92 participants, men and women aged 25–76 years old without clinical manifestation of chronic diseases but with the possible presence of cardiovascular risk factors. Carbohydrate metabolism examination, duplex scanning of the carotid arteries with the measurement of the intima-media thickness (IMT), the carotid-femoral pulse wave velocity (PWV) measurement, and 16S rRNA (V3–V4 regions) sequencing of the gut microbiota were performed in all participants. Higher Serratia abundance was associated with the increased IMT and CRP levels. Blautia representation was associated with IMT. Higher Bacteroides representation was associated with higher pulse wave velocity in non-diabetic subjects. Although this study had some limitations, we have demonstrated that the composition of the gut microbiota was associated both with atherosclerotic and arterial stiffness markers.
Open Access: This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

<Previous Article In Issue

Next Article In Issue>

Journal: Artery Research
Volume-Issue: 18 - C
Pages: 41 - 48
Publication Date: 2017/03/21
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.02.007 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Daria Kashtanova
AU  - Olga Tkacheva
AU  - Anna Popenko
AU  - Lilit Egshatyan
AU  - Alexander Tyakht
AU  - Dmitry Alexeev
AU  - Yulia Kotovskaya
AU  - Ekaterina Plokhova
AU  - Sergey Boytsov
PY  - 2017
DA  - 2017/03/21
TI  - Gut microbiota and vascular biomarkers in patients without clinical cardiovascular diseases
JO  - Artery Research
SP  - 41
EP  - 48
VL  - 18
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.02.007
DO  - 10.1016/j.artres.2017.02.007
ID  - Kashtanova2017
ER  -

download .riscopy to clipboard