Endothelin 1 and endothelial dysfunction in children with idiopathic nephrotic syndrome

Venkatesh Arumugam; Abhijeet Saha; Manpreet Kaur; Kanika Kapoor; Nimisha Arora; Trayambak Basak; Shantanu Sengupta; Ajay Bhatt; Nitin Bharadwaj; Vineeta V. Batra; Ashish Datt Upadhyay

doi:10.1016/j.artres.2017.02.006

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Volume 18, Issue C, June 2017, Pages 36 - 40

Endothelin 1 and endothelial dysfunction in children with idiopathic nephrotic syndrome

Authors

Venkatesh Arumugam^a, Abhijeet Saha^b^{, *}, Manpreet Kaur^a, Kanika Kapoor^a, Nimisha Arora^b, Trayambak Basak^c^{, d}, Shantanu Sengupta^b^{, c}^{, d}, Ajay Bhatt^c, Nitin Bharadwaj^c, Vineeta V. Batra^e, Ashish Datt Upadhyay^f

^aDivision of Pediatric Nephrology, Department of Pediatrics, Postgraduate Institute of Medical Education & Research and Associated Dr Ram Manohar Lohia Hospital, Baba Kharak Singh Marg, New Delhi, 110001, India

^bDivision of Pediatric Nephrology, Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children Hospital, New Delhi, 110001, India

^cGenomics and Molecular Medicine, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India

^dAcademy of Scientific and Innovative Research, Delhi, India

^eDepartment of Pathology, GB Pant Hospital, New Delhi, India

^fDepartment of Biostatistics, All India Institute of Medical Sciences, New Delhi, India

^*Corresponding author. Division of Pediatric Nephrology, Room No 35, Lady Harding Medical College & Kalawati Saran Children Hospital, New Delhi, 201010, India. E-mail address: drabhijeetsaha@yahoo.com (A. Saha).

Corresponding Author

Abhijeet Saha

Received 11 September 2016, Revised 8 February 2017, Accepted 21 February 2017, Available Online 17 March 2017.

DOI: 10.1016/j.artres.2017.02.006 How to use a DOI?
Keywords: Endothelin 1; Nephrotic syndrome; Endothelial dysfunction; Children
Abstract: Background: Endothelial dysfunction is the initial step for atherogenesis. Children with idiopathic nephrotic syndrome are at risk of endothelial dysfunction due to altered cholesterol metabolism which can lead to early atherosclerosis.

Methods: In this analytical study with longitudinal follow up 25 children with first episode of nephrotic syndrome (FENS) aged 1–16 years along with 25 age and gender matched healthy controls were enrolled. Endothelin 1 (ET 1) levels were measured by ELISA (Cloud Clone Corp. and assembled by USCN Inc, U.S.A). Other variables were measured using standard biochemical methods. Primary outcome measure was plasma ET 1 level in children with FENS and in controls. Secondary outcome measure was to observe the levels of ET 1 in children with FENS at 12 weeks in remission.

Results: The level of ET 1 was significantly higher (p < 0.001) in children with FENS as compared to controls. The level of ET 1 was significantly higher (p = 0.006) in SSNS at the onset of nephrotic syndrome and was significantly lower (p = 0.04) after 12 weeks of drug induced remission as compared to controls. SRNS children had higher levels of ET 1 than the steroid sensitive patients at onset but in was not statistically significant (p = 0.062). ET 1 showed significant positive correlation with total cholesterol (r = 0.462; p = 0.001) and negative correlation with serum albumin (r = −0.565; p = 0.001).

Conclusion: Plasma ET 1 levels are raised in children with FENS posing a risk of endothelial dysfunction, which persists at least in short term. Long term effects of raised plasma ET 1 needs to be studied.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 18 - C
Pages: 36 - 40
Publication Date: 2017/03/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.02.006 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Venkatesh Arumugam
AU  - Abhijeet Saha
AU  - Manpreet Kaur
AU  - Kanika Kapoor
AU  - Nimisha Arora
AU  - Trayambak Basak
AU  - Shantanu Sengupta
AU  - Ajay Bhatt
AU  - Nitin Bharadwaj
AU  - Vineeta V. Batra
AU  - Ashish Datt Upadhyay
PY  - 2017
DA  - 2017/03/17
TI  - Endothelin 1 and endothelial dysfunction in children with idiopathic nephrotic syndrome
JO  - Artery Research
SP  - 36
EP  - 40
VL  - 18
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.02.006
DO  - 10.1016/j.artres.2017.02.006
ID  - Arumugam2017
ER  -

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