Artery Research

Volume 1, Issue 2, September 2007, Pages 47 - 47

01.02 ARTERIAL STRUCTURE AND FUNCTION AND ENVIRONMENTAL EXPOSURE TO CADMIUM

Authors
R. Schutte1, T. Nawrot1, T. Richart1, L. Thijs1, H.A. Roels2, L.M. Van Bortel3, H. Struijker-Boudier4, J.A. Staessen1
1University of Leuven, Leuven, Belgium
2Université catholique de Louvain, Brussels, Belgium
3Ghent University, Ghent, Belgium
4Maastricht University, Maastricht, Netherlands
Available Online 30 August 2007.
DOI
10.1016/j.artres.2007.07.037How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Controversy exists regarding cadmium’s influence on arterial function at the population level.

Methods and results: The associations of cadmium with measures of arterial function were determined in a randomly selected population sample (n=557) from two rural areas with low and high environmental exposure to cadmium. 24-h urinary cadmium excretion was significantly higher in the high compared with the low exposure group (P<0.0001). Aortic pulse wave velocity (P=0.008), brachial pulse pressure (P=0.026) and femoral pulse pressure (P=0.008) were significantly lower in the high exposure group. Femoral distensibility (P<0.0001) and compliance (P=0.0013) were significantly higher at high exposure. By determining associations between measures of arterial function and cadmium exposure across quartiles of the 24-h urinary cadmium excretion (adjusted for sex and age), brachial (P for trend=0.015) and femoral (P for trend=0.018) pulse pressure significantly decreased and femoral distensibility (P for trend=0.008) and compliance (P for trend=0.007) significantly increased with high cadmium excretion. After full adjustment, the partial regression coefficients confirmed these associations. Pulse wave velocity (β=–0.79; P=0.004) and carotid (β=–4.20; P=0.006), brachial (β=–5.43; P=0.0001) and femoral (β=–4.72; P=0.007) pulse pressures correlated negatively, while femoral compliance (β=0.11; P=0.016) and distensibility (β=1.70; P=0.014) correlated positively with cadmium excretion.

Conclusions: Increased cadmium body burden is associated with lower aortic pulse wave velocity, lower pulse pressure throughout the arterial system, and higher femoral distensibility.

Journal
Artery Research
Volume-Issue
1 - 2
Pages
47 - 47
Publication Date
2007/08/30
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2007.07.037How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - R. Schutte
AU  - T. Nawrot
AU  - T. Richart
AU  - L. Thijs
AU  - H.A. Roels
AU  - L.M. Van Bortel
AU  - H. Struijker-Boudier
AU  - J.A. Staessen
PY  - 2007
DA  - 2007/08/30
TI  - 01.02 ARTERIAL STRUCTURE AND FUNCTION AND ENVIRONMENTAL EXPOSURE TO CADMIUM
JO  - Artery Research
SP  - 47
EP  - 47
VL  - 1
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2007.07.037
DO  - 10.1016/j.artres.2007.07.037
ID  - Schutte2007
ER  -