Artery Research

Volume 3, Issue 4, December 2009
Mini Review

5. The role of “semicarbazide-sensitive amine oxidase” in the arterial wall

N. Mercier
Pages: 141 - 147
“Semicarbazide-sensitive amine oxidase” (SSAO) metabolizes primary amines into aldehydes, hydrogen peroxide and ammonia and is largely expressed in adipocytes, lymphatic endothelial cells and vascular smooth muscle cells (VSMCs). In vitro SSAO expression and activity increase during VSMC differentiation...
Mini Review

6. Gender differences in arterial structure and function. Are men really from Mars and women from Venus?

Francesco U.S. Mattace-Raso
Pages: 148 - 150
Gender difference of cardiovascular disease is one of the most investigated and still unsolved items. Finding an answer to this, may have important implications for understanding the differences between men and women in atherosclerosis and possibly lead to the development of gender-specific treatment...
Conference Abstract

7. 1.1 ARTERIAL STIFFNESS IS RELATED TO RENAL FUNCTION IN THE GENERAL POPULATION

L.A. Tomlinson, Y. Yasmin, K. Maki-Petaja, S.S. Hickson, B.J. McDonnell, C.M. McEniery, J.R. Cockcroft, I.B. Wilkinson
Pages: 151 - 151
Introduction: Aortic stiffness is related to renal function in patients with chronic kidney disease and may contribute to the high cardiovascular mortality in this group. However, the relationship between renal function and arterial haemodynamics in the general population has not previously been reported. Methods:...
Conference Abstract

8. 1.2 VASCULAR CALCIFICATIONS AFTER CHRONIC USE OF VITAMIN-K ANTAGONISTS

B.J. van Varik, R.J.M.W. Rennenberg, A.A. Kroon, L.J. Schurgers, P.W. de Leeuw
Pages: 151 - 151
Background: Arterial calcification is commonly observed in cardiovascular disease and is associated with increased arterial stiffness, systolic hypertension and adverse cardiovascular outcome. Arterial calcification is an actively regulated process with several stimulating and inhibiting factors. An...
Conference Abstract

9. 1.3 IMPACT OF RENAL TRANSPLANTATION ON ARTERIAL STIFFNESS

J.C. Smith, L.A. Tomlinson, J.R. Bradley, A.J. Bradley, I.B. Wilkinson, C.M. McEniery
Pages: 151 - 151
Introduction: Risk of a cardiovascular event is known to increase in the period immediately post-transplantation before returning to baseline or lower. We hypothesised that this might be due to changes in arterial stiffness and/or endothelial function. Methods: We measured aortic pulse wave velocity...
Conference Abstract

10. 1.4 INCREASED AORTIC STIFFNESS IN YOUNG SUBJECTS WITH MIGRAINE

G. Schillaci, G. Pucci, I. Corbelli, P. Sarchielli, M. Mannarino, M. Pirro, P. Calabresi, E. Mannarino
Pages: 151 - 152
Background: Migraine is associated with an increased risk for ischemic stroke and other cardiovascular (CV) events, including angina, myocardial infarction, and CV death. However, the mechanisms which link migraine to CV disease remain uncertain. In the present case-control study, we hypothesized that...
Conference Abstract

11. 1.5 INCREASED CRP EARLY IN THE RA DISEASE COURSE PREDICTS AN INCREASED RISK OF CARDIOVASCULAR DISEASE AND ARTERIAL STIFFNESS: 15-YEAR FOLLOW-UP OF THE EURIDISS COHORT

S.A. Provan, K. Angel, A.G. Semb, D. Atar, T.K. Kvien
Pages: 152 - 152
Background: Patients with rheumatoid arthritis (RA) have increased cardiovascular morbidity and mortality. Objective: To explore whether early markers of RA inflammatory disease activity could predict later cardiovascular disease and arterial stiffness, and to describe the impact of later use of disease-modifying...
Conference Abstract

12. 1.6 DETRIMENTAL EFFECTS ON CAROTID PERFUSION OF INTRA-AORTIC BALLOON PUMP SUPPORT

J.E. Davies, J. Baksi, A. Sharp, B. Gerber, B. Sachdev, J. Mayet, I.S. Malik, A.D. Hughes
Pages: 152 - 152
Introduction: Intra-aortic balloon pumping is widely used to augment diastolic coronary perfusion. However, far less is known about its effects on other large arteries. In this study we assessed the effects of intra-arterial balloon pump pressure support on pressure and flow in the proximal aorta, carotid,...
Conference Abstract

13. 3.1 AORTIC STIFFNESS IN MIDDLE AGED WOMEN IS HERITABLE AND RELATES TO BLOOD PRESSURE AND AORTIC CALCIFICATION: A TWIN STUDY

M. Cecelja, B. Jiang, K. McNeill, M.L. Frost, T. Spector, P. Chowienczyk
Pages: 153 - 153
Background: Pulse wave velocity (PWV), measure of aortic stiffness, is predictive of cardiovascular events. PWV is strongly related to age and blood pressure but its relation to other risk factors and presence of calcification is unclear. We sought to determine the association between PWV and cardiovascular...
Conference Abstract

14. 3.2 IS AORTIC STIFFNESS READY FOR CLINICAL PRACTICE? RESULTS FROM THE ROTTERDAM STUDY

G.C. Verwoert, S.E. Elias-Smale, D. Rizopoulos, E.W. Steyerberg, A. Hofman, M. Kavousi, E.J.G. Sijbrands, A.P.G. Hoeks, R.S. Reneman, F.U.S. Mattace-Raso, J.C.M. Witteman
Pages: 153 - 153
Background: It has been demonstrated that aortic stiffness, as determined by the carotid-femoral pulse wave velocity, is an independent predictor of cardiovascular disease. Whether this measure is of use in cardiovascular risk stratification in clinical practice needs to be determined. We investigated...
Conference Abstract

15. 3.3 EFFECT OF CELIPROLOL ON PREVENTION OF CARDIOVASCULAR EVENTS IN VASCULAR EHLERS-DANLOS SYNDROME

K.T. Ong, J. Perdu, H. Plauchu, J. De Backer, A. De Paepe, J. Emmerich, X. Jeunemaitre, D. Germain, P. Collignon, G. Georgesco, E. Bozec, J.S. Hulot, S. Laurent, P. Boutouyrie
Pages: 153 - 154
Background: Vascular Ehlers-Danlos syndrome (vEDS) is a rare severe genetic disease which results from mutations in the gene encoding type III procollagen (COL3A1), characterized by vascular and/or hollow organic ruptures. No treatment is yet validated. We tested the ability of celiprolol, a beta1-adrenoceptor...
Conference Abstract

16. 3.4 A PRESSURE-INDEPENDENT ARTERIAL REMODELLING AND AORTA DILATATION IN TREATED PATIENTS WITH FABRY DISEASE

C. Collin, M. Bensalah, H. Beaussier, D.P. Germain, E. Bozec, E. Mousseaux, S. Laurent, P. Boutouyrie
Pages: 154 - 154
Purpose: Fabry disease is a deficiency of lysosomal enzyme α-galactosidase A leading to accumulation of glycosphyngolipids in cardiac and vascular tissues. After long-term enzyme replacement treatment, we described a continuous vascular hypertrophy whereas the aortic stiffness was paradoxically decreasing....
Conference Abstract

17. 3.5 IMPROVEMENT IN AORTIC STIFFNESS AFTER ONE YEAR OF ANTI-TUMOR NECROSIS FACTOR-α THERAPY IN PATIENTS WITH INFLAMMATORY ARTHROPATHIES IS ASSOCIATED WITH REDUCTION IN CALPROTECTIN (A PROINFLAMMATORY S100 PROTEIN)

K. Angel, S. Provan, M. Fagerhol, T.K. Kvien, D. Atar
Pages: 154 - 154
Background: Chronic inflammatory arthropathies such as rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are associated with an increased risk of cardiovascular disease. TNF-α antagonists are previously reported to improve vascular function in these patients and thus...
Conference Abstract

18. 3.6 OSTEOPROTEGERIN IS ASSOCIATED INDEPENDENTLY WITH AORTIC STIFFNESS IN PATIENTS WITH ATHEROSCLEROSIS AND IN HEALTHY SUBJECTS

M. Zagura, M. Sergejev, J. Lieberg, P. Kampus, A. Peetsalu, J. Eha, M. Zilmer, J. Kals
Pages: 154 - 154
Background: Arterial stiffening is an independent predictor for cardiovascular mortality. Preliminary studies have shown that arterial calcification may have impact on increased vascular stiffness. However, little is known about the role of calcification inhibitor osteoprotegerin (OPG) as an independent...
Conference Abstract

19. 5.1 ASSESSMENT OF THE ARTERIAL WALL BEHAVIOR ALONG THE COMMON CAROTID ARTERY AT THE LEVEL OF A PLAQUE ACCORDING TO ARTERIAL STIFFNESS GRADIENT

H. Beaussier, I. Masson, O. Naggara, D. Calvet, R. Joannides, E. Guegan-Massardier, E. Gérardin, E. Bozec, P. Boutouyrie, S. Laurent
Pages: 155 - 155
Background: We previously described longitudinal strain gradient named bending strain (BS), along the common carotid artery (CCA) with two distinct patterns (Paini, Stroke 2007, Beaussier, Hypertension 2008): Pattern A (larger radial strain at the plaque level than at adjacent CCA) and its opposite,...
Conference Abstract

20. 5.2 THE RELATIONSHIP BETWEEN LARGE ARTERY STIFFNESS, WAVE REFLECTION AND PULSATILITY IN THE MICRO-CIRCULATION: NEW INSIGHTS INTO THE MANAGEMENT OF BOTH HYPERTENSION AND DIABETES

B.J. McDonnell, J. Coulson, M. Munnery, N.S. Gale, K. Mortlock, I. Munnery, I.B. Wilkinson, C.M. McEniery, J.R. Cockcroft
Pages: 155 - 155
Background: Increased arterial stiffness is associated with a reduced buffering capacity of the large arteries, therefore predisposing the microcirculation to increased flow and pressure pulsatility. However, increased wave reflection may be protective, by reducing the amount of pulsatility transmitted...
Conference Abstract

21. 5.3 AGE-RELATED CHANGES IN THE MICROMECHANICAL PROPERTIES OF OVINE AORTA

R. Akhtar, C. Kridiotis, H.K. Graham, M.J. Sherratt, A.W. Trafford, J.K. Cruickshank, B. Derby
Pages: 155 - 155
Scanning Acoustic Microscopy (SAM) images have a spatial resolution at 1 GHz comparable to conventional optical microscopy. Each pixel in the image can be analysed to determine mechanical properties, allowing their precise correlation with microstructural components of tissue. Although loss of elasticity...
Conference Abstract

22. 5.4 THE REPEATABILITY AND VALIDITY OF PULSE WAVE VELOCITY MEASURED USING PHASE CONTRAST MAGNETIC RESONANCE IMAGING

S.S. Hickson, M. Butlin, M. Graves, I.B. Wilkinson, C.M. McEniery
Pages: 156 - 156
Background: Aortic pulse wave velocity (PWV) is an independent predictor of cardiovascular risk. Phase contrast magnetic resonance imaging (PCMRI) is a recent technique that allows PWV to be measured along the entire aorta (aPWVMRI), as well as in regions of interest. The aim of this study was to test...
Conference Abstract

23. 5.5 DOES BEHAVIOUR OF THE REFLECTED WAVE IN HUMANS SUPPORT THE PREVAILING EXPLANATION OF THE ARTERIAL PRESSURE WAVEFORM?

A.J. Baksi, J.E. Davies, N. Hadjiloizou, B. Unsworth, R. Baruah, R.A. Foale, K.H. Parker, D.P. Francis, J. Mayet, A.D. Hughes
Pages: 156 - 156
Background: It is widely believed that changes in the magnitude and timing of reflected waves reaching the heart result in deleterious cardiovascular effects. Inherent in this is the assumption that waves propagate well in the backward direction. There is limited information regarding retrograde travel...
Conference Abstract

24. 5.6 QUANTIFICATION OF BOTH SYSTOLIC AND DIASTOLIC LOCAL ARTERIAL STIFFNESS IMPROVES IDENTIFICATION OF ARTERIAL STIFFENING WITH NORMAL AGING

K. Reesink, E. Hermeling, S. Vermeersch, E. Rietzschel, M. De Buyzere, R.S. Reneman, A.P.G. Hoeks, P. Segers
Pages: 156 - 156
Background: We hypothesized that the discrepancy between local and global stiffness is explained by 1) differences in systolic and diastolic stiffness and 2) the co-existence of elastic and muscular arteries in the carotid-femoral trajectory. Methods: For 1515 subjects (age 35–55, Asklepios cohort)...
Conference Abstract

25. 6.1 LOW-GRADE INFLAMMATION AND ENDOTHELIAL DYSFUNCTION PRECEDE THE INCREASE IN PULSE PRESSURE IN TYPE 1 DIABETES:A 20-YEAR LONGITUDINAL STUDY

I. Ferreira, P. Hovind, C.G. Schalkwijk, H.-H. Parving, P. Rossing, C.D.A. Stehouwer
Pages: 157 - 157
Purpose: To investigate, longitudinally, whether increases in markers of inflammation (CRP, sICAM-1) and endothelial dysfunction (sICAM-1, sVCAM-1) are associated with and precede the increase in pulse pressure (PP) in individuals with type-1 diabetes (DM1). Methods: Inception cohort of 277 DM1 patients...
Conference Abstract

26. 6.2 IMPACT OF CHANGES IN SMOKING BEHAVIOUR BETWEEN ADOLESCENCE AND YOUNG ADULTHOOD ON ARTERIAL STIFFNESS IN YOUNG ADULTS. THE NORTHERN IRELAND YOUNG HEARTS PROJECT

R.J.J. van de Laar, I. Ferreira, C.G. Schalkwijk, M.H. Prins, J.W.R. Twisk, C.A. Boreham, C.D. Stehouwer
Pages: 157 - 157
Purpose: to investigate 1) the extent to which young adults who started smoking during adolescence and persisted doing so during young adulthood (‘persistent smokers’–PS), and those who started smoking in young adulthood only (‘starters’–SS) had greater aorto-iliac PWV than never smokers (NS); and 2)...
Conference Abstract

27. 6.3 DETERMINING EARLY CARDIOVASCULAR RISK PROFILES IN PAEDIATRIC RHEUMATIC DISEASE

T.J. Bradley, P.N. Tyrell, L. Ng, C. Slorach, J. Beyene, R. Schneider, B.M. Feldman, E.D. Silverman
Pages: 157 - 158
Objectives: Increased cardiovascular risk in adults with systemic lupus erythematosus (SLE) and rheumatoid arthritis, not explained by exposure to traditional factors alone, have prompted investigation into the role of chronic inflammation. This study aimed to determine early cardiovascular risk profiles...
Conference Abstract

28. 6.4 LONGITUDINAL FOLLOW-UP OF ARTERIAL DISTENSIBILITY IN EARLY CHILDHOOD: ROLES OF BIRTH WEIGHT, GROWTH, BLOOD PRESSURE AND EARLIER (AORTIC) ‘STIFFNESS’

A. Vyas, J. Kips, I. Gemell, N. Howard, F. Khan, P. Clayton, J.K. Cruickshank
Pages: 158 - 158
Background: Although blood pressure (BP) ‘tracks’ from early life in humans, little is known of how arterial stiffness develops over time in early childhood. Methods: UK born European (n=208) and South Asian (SA, n=99) origin infants had standardised measures of anthropometry, BP (Dynamap Critikon)...
Conference Abstract

29. 6.5 THE EPICURE STUDY: BLOOD PRESSURE AND ARTERIAL STIFFNESS IN RELATION TO BIRTH BEFORE 26 WEEKS OF GESTATION

C.M. McEniery, J. Fawkes, I.B. Wilkinson, N. Marlow, J.R. Cockcroft
Pages: 158 - 158
Background: Antenatal and postnatal growth are associated with increased arterial stiffness and cardiovascular risk (e.g. myocardial infarction and stroke) in adults born at term. Aim: We investigated cuff blood pressure (BP) and arterial waveforms in 70 extremely preterm (EP) children and in 91 age...
Conference Abstract

30. 6.6 WAIST CIRCUMFERENCE IS A BETTER PREDICTOR OF SUBCLINICAL ATHEROSCLEROSIS THAN ADIPONECTIN LEVEL

S. Holewijn, M. den Heijer, L.J. van Tits, D.W. Swinkels, A.F.H. Stalenhoef, J. de Graaf
Pages: 158 - 158
Objective: Waist circumference is clinical marker of obesity and a well-established risk factor for cardiovascular disease. Adiponectin, an adipocyte-derived hormone and new biomarker of obesity, has recently been proposed to be the missing link between obesity and increased cardiovascular risk. We evaluated...
Conference Abstract

31. 8.1 CENTRAL ARTERIAL STIFFNESS OCCURS IN BRONCHIECTASIS

N.S. Gale, J.M. Duckers, M. Munnery, S. Enright, J.R. Cockcroft, C.E. Bolton, D.J. Shale
Pages: 159 - 159
Rationale: Bronchiectasis is characterised by inflammation and airways injury, which lead to loss of airways function, factors which are associated with an increased risk of cardiovascular disease (CVD) in various populations. Central arterial stiffness (AS) a predictor of CVD risk has not been studied...
Conference Abstract

32. 8.2 COMPARISON OF THREE DIFFERENT METHODS TO CALCULATE AORTIC PULSE WAVE VELOCITY (PWV) USING A 1D MODEL OF THE SYSTEMIC CIRCULATION

B. Trachet, P. Reymond, J. Kips, A. Swillens, M. De Buyzere, B. Suys, N. Stergiopulos, P. Segers
Pages: 159 - 159
Aortic pulse wave velocity (PWV) is a measure of the stiffness of the large arteries, and is often used as indicator of clinical cardiovascular risk. Yet, methodological issues still exist on how PWV should best be measured. We have used a 1D arterial network computer model of the systemic circulation...
Conference Abstract

33. 8.3 MRI OF ENDOTHELIAL ADHESION MOLECULES IN CAROTID ATHEROSCLEROSIS USING TARGETED ULTRASMALLSUPERPARAMAGNETIC PARTICLES OF IRON OXIDE (USPIO) - TOWARDS AN IN VIVO MODEL

J.M.S. Chan, K. Bhakoo, C. Monaco, R.G.J. Gibbs
Pages: 159 - 160
Introduction: There is currently no clinical imaging techniques available to assess the degree of inflammation associated with atherosclerotic plaques. This study aims at visualising and characterising atherosclerosis using targeted USPIO as an MRI probe for detecting inflamed endothelial cells. Method:...
Conference Abstract

34. 8.4 ARTERIAL COMPLIANCE AND CAROTID ATHEROSCLEROSIS IN APOLIPOPROTEIN A-I AMYLOIDOSIS (LEU75PRO)

A. Paini, M.L. Muiesan, M. Salvetti, C. Aggiusti, E. Belotti, C. Agabiti Rosei, G. Gregorini, G. Cancarini, E. Agabiti Rosei
Pages: 160 - 160
Background: Hereditary amyloidosis are late-onset autosomal dominant disorders characterized by amyloid deposition in various tissues. Among them, Apolipoprotein A-I amyloidosis (Leu75Pro) is a rare autosomal dominant condition in which renal, hepatic, and testicular involvement has been demonstrated.No...
Conference Abstract

35. 8.5 INCREASED ARTERIAL STIFFNESS IN PATIENTS WITH ALPHA 1 ANTITRYPSIN DEFICIENCY

J.M. Duckers, D.J. Shale, N.S. Gale, R. Stockley, J.R. Cockcroft, C.E. Bolton
Pages: 160 - 160
Rationale: Alpha 1 Antitrypsin (AAT) deficiency is a familial cause of emphysema, due to reduced antiproteolytic activity within lungs. Systemic manifestations however, remain little explored. We have previously demonstrated increased arterial stiffness (AS) in patients with COPD and hypothesised that...
Conference Abstract

36. 8.6 ELECTRICAL CAROTID BARORECEPTOR ACTIVATION LOWERS RENAL ARTERY IMPEDANCE AND STIFFNESS IN AN ACUTE CANINE MODEL

P. Segers, D. Wagner, K. Ludwig, A.W. Cates, D. Georgakopoulos
Pages: 160 - 160
Background: The exact mechanism by which electrical carotid baroreceptor activation (CBA) lowers blood pressure in patients with hypertension has yet to be fully elucidated. Given the central role of the kidneys in blood pressure regulation, the aim of this study was to assess the impact of CBA on renal...
Conference Abstract

37. P1.01 PULSE WAVE VELOCITY: HOW TO ASSESS THE DISTANCE?

D. Mahieu, D. Devos, J. Kips, E. Achten, P. Segers, L. Van Bortel
Pages: 161 - 161
Objective: Pulse wave velocity (PWV) is accepted as the standard technique to assess aortic stiffness. While the carotid-femoral transit time can be assessed with high accuracy, the measurement of the aortic length is, however, less accurate. Several approaches for measuring aortic length over the body-surface...
Conference Abstract

38. P1.02 ABDOMINAL AORTIC CALCIFICATION DETECTION USING DUAL-ENERGY X-RAY ABSORPTIOMETRY (DXA): COMPARISON WITH COMPUTED TOMOGRAPHY (CT)

M. Cecelja, M.L. Frost, T. Spector, P. Chowienczyk
Pages: 161 - 161
Background: Abdominal aortic calcification (AAC) is an independent determinant of cardiovascular events. Computed tomography (CT) is currently the gold standard for measuring aortic calcification but is limited by relatively high radiation exposure. Lateral dual-energy X-ray absorptiometry (lateral-DXA)...
Conference Abstract

39. P1.03 A COMPARISON OF CENTRAL BLOOD PRESSURES AND AUGMENTATION INDEX ESTIMATED BY OMRON-HEM9000, ARTERIOGRAPH AND SPHYGMOCOR

R. Rezai, G. Goudot, J. Finn, C. Winters, F. Wu, J.K. Cruickshank
Pages: 161 - 161
Aims: To compare central systolic blood pressure (cSBP) and augmentation index (AIx) from 2 recently introduced devices Omron-HEM9000 (OM) and Arteriograph (AG) not using a transfer function with that of the widely used SphygmoCor (SC), which together with another radial device OM is calibrated on brachial...
Conference Abstract

40. P1.04 INVASIVE ASSESSMENT OF AORTIC PRESSURE WAVES: COMPARISON BETWEEN PRESSURE WIRE AND FLUID FILLED CATHETER

S. Wassertheurer, B. Hametner, C.C. Mayer, B. Eber, T. Weber
Pages: 161 - 162
Introduction: Parameters of wave reflection (augmentation pressure - AP or augmentation index – AIx) are powerful independent prognostic markers in patients with coronary artery disease. However, the invasive investigation of arterial waveforms is still confined to expensive equipment. The aim of this...
Conference Abstract

41. P1.05 ASSESSMENT OF ARTERIAL STIFFNESS IN HYPERTENSION: COMPARISON OF OSCILLOMETRIC (ARTERIOGRAPH), PIEZO-ELECTRONIC (COMPLIOR), AND TONOMETRIC (SPHYGMOCOR) TECHNIQUES

A. Mahmud, N. Jatoi, J. Feely
Pages: 162 - 162
Arterial stiffness, measured as aortic pulse wave velocity (PWV), and wave reflection, measured as augmentation index (AIx) are independent predictors, for total and cardiovascular morbidity and mortality. The aim of this study was to compare a new device, based on oscillometric pressure curves (Arteriograph)...
Conference Abstract

42. P1.06 THE ACCURACY OF CENTRAL SYSTOLIC BLOOD PRESSURE DETERMINED FROM THE SECOND SYSTOLIC PEAK OF THE PERIPHERAL PRESSURE WAVEFORM

S.S. Hickson, M. Butlin, F. Mir, J. Graggaber, J. Cheriyan, M. Yasmin, J.R. Cockcroft, I.B. Wilkinson, C.M. McEniery
Pages: 162 - 162
Central blood pressure may be a better predictor of cardiovascular risk than peripheral blood pressure. The central systolic blood pressure (cSBP) can be estimated from the late systolic shoulder of the radial pulse waveform (pSBP2). We compared pSBP2 with cSBP derived by a generalized transfer function...
Conference Abstract

43. P1.07 MEASUREMENT OF CAROTID INTIMA-MEDIA THICKNESS IN HEALTHY PERSONS AND PATIENTS WITH TYPE 2 DIABETES - A REPRODUCIBILITY STUDY

L. Lundby Christensen, T. Almdal, A. Vaag, B. Carstensen, L. Tarnow, N. Wiinberg
Pages: 162 - 162
Background: Carotid intima-media thickness (IMT) measured by B-mode ultrasound is a sensitive and non-invasive method for detection of subclinical cardiovascular disease (CVD) and is often used as primary outcome measure in clinical trials as a surrogate marker of CVD. The purpose of the present study...
Conference Abstract

44. P1.08 COMPARING PROXIMAL AND DISTAL OCCLUSION FOR TESTING ENDOTHELIAL FUNCTION USING FOREARM ISCHEMIA – HYPERAEMIA

P.J. Forcada, S.A. Gonzalez, D. Olano, S. Obregon, C. Castelaro, C. Kotliar
Pages: 162 - 162
Introduction: There are several approaches to assess endothelial function using forearm ischemia - hyperaemia (FMD). The principal difference is whether flow is stopped in the root of the arm (proximal or P) or the wrist (distal or D). P induces “non pulsatile ischemia”, and D, “pulsatile ischemia”,...
Conference Abstract

45. P1.09 RESULTS OF THE TWO METHODS OF AORTIC STIFFNESS ESTIMATION IN YOUNG AND MIDDLE AGED PATIENTS WITH CORONARY ARTERY DISEASE

M.V. Andreevskaya, Machmudova KhA, N.M. Moiseeva, S.G. Kozlov, T.V. Balakhonova, M.A. Saidova, A.N. Rogoza
Pages: 163 - 163
Aim: The assessment of aortic stiffness in young and middle aged men with coronary artery disease (CAD). Materials and methods: This study was carried out in 49 CAD patients aged 43,5±4,8 years with coronary artery stenosis diagnosed by angiography and 29 healthy volunteers (the control group) aged...
Conference Abstract

46. P1.10 COMPARATIVE STUDY OF PULSE WAVE VELOCITY BY TWO DIFFERENT DEVICES

A. Vicente Casanova, F. Martinez Garcia, E. Solaz Moreno, O. Calaforra Juan, M. Bori Gines, J. Redon i Mas
Pages: 163 - 163
Background: According to the 2007 European Society of Hypertension guidelines, measurement of arterial stiffness (AS) is recommended in patients with arterial hypertension (HT). The carotid-femoral pulse wave velocity (PWV) appears to be the “gold standard” for evaluation on vascular changes in these...
Conference Abstract

47. P1.11 CAROTID STIFFNESS AND BAROREFLEX SENSITIVITY: THE EPP3 STUDY

A. Boudard, D. Laude, J.P. Empana, B. Pannier, K.T. Ong, F. Thomas, J. Perruca, X. Jouven, S. Laurent, P. Boutouryie
Pages: 163 - 163
Arterial baroreflex sensitivity (BS) is dependent on distension rate of baroreceptors, itself dependent on arterial stiffness. Differences in BS between younger and older subjects, and normotensive and hypertensive patients may be explained by differences in arterial stiffness. The objective was to demonstrate...
Conference Abstract

48. P1.12 PROGNOSTIC ROLE OF REVERSIBLE ARTERIAL STIFFNESS IN MEN WITH CORONARY ARTERY DISEASE

I.A. Orlova, E. Nuraliev, G. Makarova, E. Yarovaya, F.T. Ageev
Pages: 163 - 163
Background: Men with CAD have been shown to have abnormal arterial stiffness. Arterial function may change over time, according to treatment; the prognostic value of these changes has not been investigated. Objectives: The aim of the present study was to assess whether an improvement of lager artery...
Conference Abstract

49. P6.01 ULTRASOUND EVALUATION OF LOCAL ARTERIAL STIFFNESS: FEASIBILITY STUDY IN AN ANIMAL MODEL OF ADVANCED ATHEROSCLEROSIS

E. Bianchini, C. Giannarelli, F. Faita, G. Cimmino, V. Gemignani, J.J. Badimon
Pages: 164 - 164
Atherosclerosis is a pathological process affecting arterial elasticity. The rabbit is one of the most widely used animal models for atherosclerosis research. The aim of this study was to evaluate the feasibility of a method for the automatic assessment of local vascular stiffness in rabbits. An off-line...
Conference Abstract

50. P6.02 SIMULTANEOUS MEASUREMENTS OF THE AORTIC AND COMMON CAROTID DISTENSION WAVEFORMS BY MEANS OF ULTRASOUND

K.G. van den Hengel, P.J. Brands, E.M.H. Bosboom, F.N. van de Vosse
Pages: 164 - 164
Figure 1AA and CCA pulse waveform measured during 6 heartbeats in 1 volunteer. Cardiac and arterial function is reflected in the distension (change in diameter) waveforms of central arteries. For analyses, commonly the distension waveform of the common carotid artery (CCA) is used, as the CCA is superficial...
Conference Abstract

51. P6.03 SIMULTANEOUS UPPER ARM AND THIGH CUFF PULSE VOLUME RECORDING FOR RAPID ESTIMATION OF CENTRAL PULSE WAVE VELOCITY: COMPARISON WITH CAROTID-FEMORAL TONOMETRY

A. Donald, Z. Maniou, K. Connell, K. McNeill, T. Sanders, P. Chowienczyk
Pages: 164 - 164
Objectives: Aortic pulse wave velocity (PWV) is usually estimated by sequential (ECG referenced) carotid-femoral tonometry using the SphygmoCor system (Atcor, Australia). This can be technically challenging and operator dependant. Here we evaluate a simple, operator independent method of estimating central...
Conference Abstract

52. P6.04 COMPARISON BETWEEN PULSE WAVE VELOCITY ASSESSMENT IN THE OBESE BY TRANSCUTANEOUS DEVICES COMPARED TO PHASE CONTRAST MAGNETIC RESONANCE IMAGING

L. Joly, A. Kearney-Schwartz, P. Salvi, D. Mandry, G. Karcher, P. Rossignol, P.Y. Marie, F. Zannad, A. Benetos
Pages: 164 - 165
Background: Abdominal obesity is a clinical setting recognized as a difficult situation to assess transcutaneous pulse wave velocity (PWV). PWV measurement between carotid and femoral sites is considered as the gold standard measurement of aortic stiffness. Arterial stiffness is an important parameter...
Conference Abstract

53. P6.05 MRI AORTIC THORACIC ELASTIC PROPERTIES ASSESSMENT COMPARED TO ARTERIAL STIFFNESS ASSESSMENT BY TRANSCUTANEOUS DEVICES

L. Joly, A. Kearney-Schwartz, P. Salvi, D. Mandry, P. Rossignol, G. Karcher, P.Y. Marie, F. Zannad, A. Benetos
Pages: 165 - 165
Background: Aortic elasticity properties (aortic distensibility, compliance, elastic modulus, and stiffness index) can be evaluated by cross-sectional thoracic aorta areas measurements at 2 times of the cardiac cycle (peak systolic and end-diastolic phases) with PC-cine MRI series. Pulse wave velocity...
Conference Abstract

54. P6.06 CAN WE LEARN ANYMORE ABOUT ARTERIAL FUNCTION FROM THE VALSALVA MANOEUVRE? WAVE INTENSITY ANALYSIS CAN INFORM US ABOUT RESERVOIR FUNCTION

A.J. Baksi, J.E. Davies, N. Hadjiloizou, R. Baruah, B. Unsworth, R.A. Foale, K.H. Parker, D.P. Francis, J. Mayet, A.D. Hughes
Pages: 165 - 165
Background: The Valsalva manoeuvre (VM) is a physiological manoeuvre capable of generating profound changes in venous return. Although its physiology has been extensively described, the predominant focus has been on dynamic effects on cardiac preload with subsequent impact on cardiac output. However,...
Conference Abstract

55. P6.07 METHODOLOGICAL ASPECT OF BRACHIAL FLOW MEDIATED DILATION: IMPROVEMENT OF REPRODUCIBILITY

F. Faita, V. Gemignani, E. Bianchini, F. Stea, M. Demi, L. Ghiadoni
Pages: 165 - 165
Brachial artery flow-mediated dilation (FMD) is the most widely used technique for assessing endothelial function in humans. FMD is reduced in the presence of cardiovascular risk factors and diseases and it is an independent predictor of events. However, its major limitation is the relatively low reproducibility....
Conference Abstract

56. P6.08 CHARACTERIZATIONS OF THE ARTERIAL SYSTEM COMPARED

N. Westerhof, B.E. Westerhof
Pages: 165 - 166
Systolic pressure, Ps, and pulse pressure, PP, are determined by heart and arterial system. We here compare systemic arterial system characterizations alone, and mention their use and limitations (aspects). 1.Peripheral resistance, Rp. Required: Mean Pressure and Cardiac Output; Characterization:...
Conference Abstract

57. P6.09 ULTRASONOGRAPHIC MEASUREMENT OF ARTERIAL WALL AND INTRAPLAQUE STRAIN IN THE CAROTID BULB AND COMMON CAROTID ARTERY

F.H.B. Schreuder, I.M. Graf, W.H. Mess, A.P.G. Hoeks
Pages: 166 - 166
Background: Transient ischemic attacks and stroke are commonly caused by vulnerable plaques in the carotid bulb. Noninvasive ultrasound imaging techniques, revealing spatial inhomogeneities in strain distribution, could possibly improve the timely diagnosis of plaque at risk of rupturing. Methods: In...
Conference Abstract

58. P6.10 A COMPARISON BETWEEN THE VICORDER AND SPHYGMOCOR DEVICES FOR THE NON-INVASIVE ASSESSMENT OF CENTRAL BLOOD PRESSURE

G. Pucci, L. Whittaker, S.S. Hickson, J. Cheriyan, G. Schillaci, C.M. McEniery, I.B. Wilkinson
Pages: 166 - 166
Background: There is increasing evidence that central (aortic) blood pressure (BP) may be a more important determinant of cardiovascular risk than brachial BP. Most of actual devices to assess central BP non-invasively are partially operator-dependent, or rely on the detection of the late systolic shoulder...
Conference Abstract

59. P6.11 RELATIONSHIPS BETWEEN ENDOTHELIAL FUNCTION, ARTERIAL ELASTICITY AND BAROREFLEX SENSITIVITY

A. Pinter, T. Horvath, D. Cseh, M. Kollai
Pages: 166 - 166
Endothelium derived nitric oxide (NO) increases conduit artery distensibility, through relaxation of vascular smooth muscle. Barosensory wall distensibility influences the mechanical component of baroreflex sensitivity (BRS) by modifying the baroreceptor stimulus. NO bioavailability may also affect the...
Conference Abstract

60. P6.12 BRACHIAL ARTERY REACTIVITY IS DIRECTLY PROPORTIONAL TO BASAL BRACHIAL ARTERY TONE: POSSIBLE CONFOUNDER IN MEASURING ENDOTHELIAL FUNCTION

V. Maher, C. Markham, A. OHalloran, M. O’Dowd, M. Carey, A. Brown, D. McInerney
Pages: 166 - 166
Brachial artery reactivity following compression is used as a surrogate marker of endothelial function. Brachial diameter increases exceeding 10% indicate normal endothelial function. We investigated if basal brachial artery tone influenced brachial artery reactivity. One hundred never smoking, healthy,...
Conference Abstract

61. P9.01 NON - INVASIVE EVALUATION OF ATHEROSCLEROTIC PLAQUE COMPOSITION: COMPARISON BETWEEN THE REFERENCE ANALYZER AND A NEW GRAY SCALE MEDIAN COLOR-MAPPING SOFTWARE

P.J. Forcada, S.A. Gonzalez, D. Olano, E. Cavanagh, S. Obregon, C. Castelaro, C. Kotliar
Pages: 167 - 167
Introduction: The non-invasive analysis of plaque echolucency (ECL) with Adobe Photoshop® has proven to reduce the subjectivity of ultrasonic evaluation of atherosclerosis. However, ECL provides information concerning only one of the aspects that contribute to vulnerability (plaque echodensity). Hemodyn...
Conference Abstract

62. P9.02 EVALUATION OF PULSE WAVE VELOCITY AND AUGMENTATION INDEX IN SUPINE AND SITTING POSITION

J. Nuernberger, R. Michalski, A. Opazo Saez, A. Kribben
Pages: 167 - 167
Background: Despite the introduction of arterial stiffness measurements in the recommendation of the European Societies for Hypertension and Cardiology, pulse wave velocity (PWV) and augmentation index (Aix) are still not used routinely in clinical practice. Possibly, current techniques, although non-invasive,...
Conference Abstract

63. P9.03 REGIONAL AGE-RELATED CHANGES IN AORTIC PULSE WAVE VELOCITY AND SYSTOLIC DIAMETER MEASURED USING MAGNETIC RESONANCE IMAGING

S.S. Hickson, M. Butlin, M. Graves, I.B. Wilkinson, C.M. McEniery
Pages: 167 - 167
Aortic pulse wave velocity (PWV) is an independent predictor of cardiovascular risk. However, PWV is usually determined between the carotid and femoral sites, ignoring the proximal ascending aorta which may stiffen most with age. We tested this hypothesis by assessing regional PWV and aortic diameter...
Conference Abstract

64. P9.04 A NEW METHOD FOR CONTINUOUS MONITORING OF CENTRAL ARTERIAL STIFFNESS DURING STRESS

F. Faita, V. Gemignani, E. Bianchini, R.M. Bruno, T. Bombardini, L. Ghiadoni
Pages: 167 - 167
The continuous monitoring of arterial stiffness during pharmacological and dynamic stress is an intriguing and partially unexplored topic. In this work we present a new method for the continuous assessment of the aortic-to-carotid pulse transit time (PTT), which is inversely proportional to the pulse...
Conference Abstract

65. P9.05 INFLUENCE OF PERIPHERAL BLOOD PRESSURE CALIBRATION ON THE ESTIMATION OF CENTRAL BLOOD PRESSURE

A. Guilcher, S. Brett, B. Clapp, P. Chowienczyk
Pages: 168 - 168
Objective: To examine the influence of calibration of peripheral blood pressure on the estimation of central systolic blood pressure (cSBP) from peripheral arterial waveforms using a transfer function. Methods: Central aortic pressure was measured with a pressure tipped catheter (Millar, Houston, Texas)...
Conference Abstract

66. P9.06 EVIDENCE FOR A ROLE OF THE VASCULAR ENDOTHELIUM IN THE REGULATION OF ARTERIAL WALL VISCOSITY IN VIVO IN HUMANS

J. Bellien, M. Iacob, C. Thuillez, R. Joannides
Pages: 168 - 168
Although the viscoelasticity of large arteries has been extensively investigated, few studies have focused on arterial wall viscosity (AWV) itself and its regulation by the endothelium in vivo. This is of particular importance since AWV is a major source of energy dissipation through the vascular system...
Conference Abstract

67. P9.07 ULTRASOUND MAPPING OF THE SUPERFICIAL VEINS IN HEALTHY SUBJECTS

L. Araujo, K. Van Canneyt, A. Bode, R.N. Planken, P. Segers, P. Verdonck
Pages: 168 - 168
Objectives: Anatomical and physiological data on the forearm venous vascular bed is needed to (i) gain insight into the complex arterial and venous remodeling processes after creation of an arterio-venous fistula, and (ii) provide input data for computer models of the forearm vasculature. Methods: Ultrasound...
Conference Abstract

68. P9.08 ASSESSMENT OF PLAQUE FORMATION IS A PRE-REQUISITE TO PREDICT CARDIOVASCULAR COMPLICATIONS USING CAROTID INTIMA MEDIA THICKNESS

J.R.M. Blekemolen, J.D. Barth, M.M.B. Zonjee
Pages: 168 - 169
Role and function of the Carotid Intima Media Thickness (CIMT) and atherosclerotic Plaque (P) in clinical management of cardiovascular risk factors is yet unclear. Cardiovascular Risk Factor Stratification (SCORE) and CIMT with P typing and visualization were assessed in 269 asymptomatic individuals...
Conference Abstract

69. P9.09 LARGE ARTERY FUNCTION AND VENTRICULAR ARTERIAL COUPLING DURING PROLONGED BED REST

F. Santini, C. Morizzo, E. Malshi, M. Kozakova, P. Salvi, S. Pedri, M. Pagani, C. Palombo
Pages: 169 - 169
Background: prolonged circulatory unloading associated with head-down tilt bed rest (HDTBR) is followed by cardiovascular deconditioning. Aim of the study was to investigate to what extent large artery function and arterial-ventricular coupling (VA) are involved. Methods: ten healthy male volunteers...
Conference Abstract

70. P9.10 PULSE WAVE REFLECTION IN SUPINE AND STANDING HEALTHY YOUNG AND ELDERLY

S.C.A.T. Davis, B.E. Westerhof, L.W.J. Bogert, N. Westerhof, J.J. van Lieshout
Pages: 169 - 169
Objective. Pressure wave reflection poses a load on the heart often augmenting pressure and adversely affecting cardiac output. Reflection effects are age dependent and may be altered by sympathetic activation by postural stress. We sought to determine the influence of standing on wave reflection and...
Conference Abstract

71. P4.01 EFFECTS OF TOCOLYTICAL MEDICATIONS ON THE PERIPHERAL AND CENTRAL HEMODYNAMICS OF HEALTHY FEMALE VOLUNTEERS

I.G.M. Fabry, P. De Paepe, L. Van Bortel
Pages: 170 - 170
Objective: Atosiban and ritodrine are frequently used tocolytics. Only a few studies investigated the hemodynamic effects of atosiban. We therefore aimed to study the central and peripheral hemodynamics of both medications. Methods: Twenty healthy female volunteers (19–41 yrs) were given atosiban (300...
Conference Abstract

72. P4.02 EFFECTS OF TOCOLYTICAL MEDICATION ON BLOOD PRESSURE AND BLOOD PRESSURE AMPLIFICATION

I.G.M. Fabry, P. De Paepe, L. Van Bortel
Pages: 170 - 170
Objective: Atosiban (oxytocin-antagonist) and ritodrine (β-agonist) are frequently used tocolytics. Only a few studies investigated the hemodynamic effects of atosiban. We therefore aimed to study the effects on the blood pressure (BP) and BP-amplification. Methods: Twenty healthy female volunteers...
Conference Abstract

73. P4.03 SUB-ACUTE EFFECTS OF BLOOD PRESSURE LOWERING WITH AMLODIPINE OR LISINOPRIL ON LOCAL CAROTID ARTERY HAEMODYNAMICS

B. Ariff, F. Glor, L. Crowe, Y. Xu, W. Vennart, D. Firmin, S. Thom, A.D. Hughes
Pages: 170 - 171
Introduction: Anti-hypertensive agents differ in their ability to slow progression of the increase in carotid artery intima-media thickness (IMT) with disease and have different effects on the lumen diameter (LD) of the carotid artery. We hypothesised that changes in flow and shear stress in the common...
Conference Abstract

74. P4.04 LONG-TERM REDUCTION IN AORTIC STIFFNESS IN HYPERTENSIVE PATIENTS IS PARTLY INDEPENDENT OF MBP REDUCTION

C. Collin, H. Ait-Oufella, K.T. Ong, H. Beaussier, E. Bozec, C. Dufouil, P. Boutouyrie, S. Laurent
Pages: 171 - 171
Purpose: A decrease in aortic stiffness could theoretically occur after several years of treatment but reduction has never been unequivocally demonstrated in clinical practice. Association with changes in blood pressure remained unclear. Methods: This longitudinal observational study was conducted in...
Conference Abstract

75. P4.05 NONINVASIVE PULSE WAVE ANALYSIS FOR MONITORING THE CARDIOVASCULAR EFFECTS OF PNEUMOPERITONEUM DURING LAPAROSCOPIC CHOLECYSTECTOMY

Sz. Lengyel, P. Sarkany, E. Szelei, E. Komonyi, M. Juhász, E. Katona, G. Paragh, B. Fülesdi, D. Páll
Pages: 171 - 171
Aim of Study: Due to absorption of carbon dioxide and elevated intraabdominal pressure, pneumoperitoneum during laparoscopic cholecystectomy has potentially harmful intraoperative cardiovascular effects. Our aim was to test the usefulness of a non-invasive method for detecting these hemodynamic parameters. Methods:...
Conference Abstract

76. P4.06 DIFFERENTIAL EFFECTS OF NEBIVOLOL AND ATENOLOL ON CAROTID ARTERIAL WAVE INTENSITY

C. Park, J. Sever, A.W. Khir, C.L. Chang, S. Thom, A.D. Hughes, N. Poulter
Pages: 171 - 171
Background The hemodynamic effects of the vasodilator β-blocker nebivolol may differ from those of a conventional agent. Wave intensity analysis can describe the energy transported by wavefronts in the arterial system in the direction of wave propagation. A non-invasive ultrasound-based technique [1]...
Conference Abstract

77. P4.07 INFLUENCE OF LONG-ACTING ISOSORBIDE-5-MONONITRATE ADMINISTRATION ON LARGE ARTERIAL STIFFNESS IN PATIENTS WITH ESSENTIAL HYPERTENSION

F.T. Ageev, E.M. Seredenina, I.A. Orlova, A.G. Plisuk, I.V. Barinova
Pages: 171 - 172
AIM of this study was to evaluate the clinical efficacy of long-acting nitrates, isosorbide-5-mononitrate (ISMN), in addition to ACE inhibitor on artery stiffness in patients with essential hypertension. MATERIALS AND METHODS. 40 hypertensive patients (mean age 61.3±7.4 years, 9 male, 31 female, mean...
Conference Abstract

78. P4.08 ARTERIAL HYPERTENSION AND CORONARY REVASCULARIZATION SURGERY: A CLINICAL CHARACTERIZATION OF 90 PATIENTS

L.M. Pupi, M. Leonardi, F. Calabria, E. Sampo
Pages: 172 - 172
Objectives: evolution of hypertensive patients during their stay in the CCU after myocardial revascularization surgery (MRS). Methods: retrospective study with 90 patients. Results: prevalence of AHT before surgery was 86.7%; 61.3% were treated with BB, 39% received ACEI, 11% calcium antagonists and...
Conference Abstract

79. P4.09 EFFECT OF VARDENAFIL ON ARTERIAL STIFFNESS AND WAVE REFLECTION

D. Terentes-Printzios, C. Vlachopoulos, N. Ioakeimidis, K. Rokkas, K. Aznaouridis, K. Baou, C. Stefanadis
Pages: 172 - 172
Introduction: While vardenafil is widely prescribed for erectile dysfunction, its effect on arterial function is not established. Arterial stiffness and wave reflections are markers of cardiovascular disease and predictors of cardiovascular risk. We assessed the acute effect of vardenafil on arterial...
Conference Abstract

80. P4.10 EFFECT OF SHORT-TERM PERINDOPRIL THERAPY ON ARTERIAL STIFFNESS AND ENDOTHELIAL FUNCTION IN DIASTOLIC HEART FAILURE PATIENTS

Y. Osmolovskaya, A. Glechan, B. Kulev, A. Skvortsov, V. Mareev, S. Tereshenko
Pages: 172 - 172
Background: Vascular load is an important determinant of ventricular function. Understanding the physiologic basis of vascular load is central to the development of new strategies and drugs to treat HF. Aim: to evaluate arterial stiffness, endothelial function, clinical status at baseline and in 6 months...
Conference Abstract

81. P4.11 LOWER LIMB VASOMOTOR AND FIBRINOLYTIC EFFECTS OF KININ RECEPTOR AGONISTS IN MAN

N.L. Cruden, N.N. Lang, T.J. MacGillivray, N.G. Uren, K.A. Fox, D.E. Newby
Pages: 173 - 173
Background: Vascular B1 kinin receptor expression is upregulated in human atheroma and the presence of angiotensin-converting enzyme inhibition (ACEi), but its role in man remains unclear. We examined vasomotor and fibrinolytic responses to selective kinin receptor agonism in the human femoral circulation...
Conference Abstract

82. P4.12 EGRESS OF FUNCTIONALLY COMPETENT PROGENITOR CELLS OVER-EXPRESSING CXCR4 FROM THE BONE MARROW FOLLOWING CARDIAC SURGERY WITH THE USE OF CARDIOPULMONARY BYPASS

O. Dotsenko, Q. Xiao, Q. Xu, M. Jahangiri
Pages: 173 - 173
Background: The mechanisms of endogenous progenitor cell trafficking in response to tissue injury in humans are poorly understood. Methods: We based our study on a model of transient myocardial injury, provoked by the use of cardiopulmonary bypass during cardiac surgery in 39 patients. Bone marrow (BM)...
Conference Abstract

83. P4.13 REDUCTION OF ARTERIAL STIFFNESS AND CENTRAL BP IN PATIENTS WITH ARTERIAL HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA ON CPAP- THERAPY

Z.N. Sukmarova, A.Yu. Litvin, A.N. Rogoza, I.E. Chazova
Pages: 173 - 173
Arterial stiffness (AS) and central BP (CBP) are new «target-objects» for Antihypertensive Therapy (AT), but the possibility to correction these parameters on nonmedicament treatment is discussed. Aim: To research the possibilities of correction of AS and CBP by AT and Continuous Positive Airway Pressure...
Conference Abstract

84. P5.01 THE EFFECT OF PULMONARY REHABILITATION ON ARTERIAL STIFFNESS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

N.S. Gale, J.M. Duckers, D. Proud, T. Lines, S. Enright, J.R. Cockcroft, D.J. Shale, C.E. Bolton
Pages: 173 - 174
Background: We have previously shown increased arterial stiffness using aortic pulse wave velocity (PWV) in patients with COPD. Pulmonary rehabilitation (PR) (exercise, education and nutritional advice) has respiratory and functional benefits, though effects on cardiovascular (CV) risk have not been...
Conference Abstract

85. P5.02 EFFECT OF ACUTE INTENSE EXERCISE ON ARTERIAL STIFFNESS

D. Kardara, C. Vlachopoulos, A. Anastasakis, K. Baou, I. Dima, D. Terentes-Printzios, G. Antoniou, A. Gravos, G. Angelidis, C. Stefanadis
Pages: 174 - 174
Purpose: Aortic stiffness and wave reflections are determinants of left ventricular performance and independent predictors of cardiovascular risk. Though it is well recognized that regular aerobic exercise can affect arterial stiffness and wave reflections, the acute effect of intense aerobic exercise...
Conference Abstract

86. P5.03 ACUTE VASCULAR EFFECTS OF RECOMBINANT HUMAN TSH IN YOUNG SUBJECTS FROM CHERNOBYL AREA FOLLOWED-UP FOR PREVIOUS DIFFERENTIATED THYROID CANCER

L. Ghiadoni, R.M. Bruno, F. Faita, E. Bianchini, A.I. Corciu, E. Daghini, L. Landini, F. Stea, P. Fallahi, E. Picano, A. Antonelli
Pages: 174 - 174
Objectives: To evaluate the effect of recombinant human TSH (rhTSH) on endothelial function, aortic and carotid stiffness, and wave reflection in a population living in the Chernobyl area at the time of 1986 blast, treated with thyroidectomy for thyroid cancer. Methods: 23 subjects (age 26±3 years,...
Conference Abstract

87. P5.04 RELATIONSHIP BETWEEN ENDOTHELIAL FUNCTION, INTIMA-MEDIA COMPLEX THICKNESS AND BILIRUBIN LEVELS IN PATIENTS WITH METABOLIC SYNDROME

O.A. Polikina, V.V. Vikentyev
Pages: 174 - 174
Endothelial dysfunction (ED) and carotid artery intima-media complex thickening (IMT) are regarded as predictors for the progress of atherosclerosis. The anti-oxidant properties of bilirubin and its ability to prevent oxidation of lipids of low density lipoproteins, and thus, development of vascular...
Conference Abstract

88. P5.05 INTERICTAL ARTERIAL WALL PARAMETERS IN WOMEN WITH MIGRAINE

K. Ryliskiene, D. Jatuzis, L. Ryliskyte, M. Kovaite, A. Marcijoniene, A. Laucevicius
Pages: 174 - 175
Objective: According to data of epidemiological and clinical studies, migraine with aura (MA) is associated with cardiovascular disorders, and migraine without aura (M0) is linked to carotid artery dissection. The aim of this cross-sectional study was to evaluate and compare arterial wall parameters...
Conference Abstract

89. P5.06 INCREASED ARTERIAL STIFFNESS AND SYSTOLIC BLOOD PRESSURE FOLLOWING SUBCLAVIAN FLAP REPAIR FOR AORTIC COARCTATION IN INFANCY

D. Kenny, J. Polson, J.R. Cockcroft, R. Martin, J. Paton, A. Wolf
Pages: 175 - 175
Objectives: To compare the effect of Subclavian Flap Repair (SFR) versus end-to-end anastomosis (EEA) on arterial stiffness and systolic blood pressure in young children with aortic coarctation. Methods: Pulse wave velocity (PWV) was measured using a pulse volume recording technique (Vicorder, Skidmore...
Conference Abstract

90. P5.07 LOCAL VASCULAR PROPERTIES AND AUTONOMIC NERVOUS REACTIVITY IN THE THIRD TRIMESTER OF PREGNANCY

N. Potocnik, K. Cankar, Z. Melik, V. Starc
Pages: 175 - 175
It is known that reproductive hormones influence both local vascular properties and autonomic nervous reactivity. The aim of our study was to measure the small artery compliance, cutaneous LD flux response to local cooling and heart rate variability in women in the third trimester of normal pregnancy...
Conference Abstract

91. P5.08 INDICES OF EARLY ATHEROSCLEROSIS AND ARTERIAL STIFFNESS AND CEREBRAL BLOOD FLOW VELOCITY

A. Kwater, J. Gąsowski, T. Grodzicki
Pages: 175 - 175
Objective: The aim of the study was to asses the relationship between structural (IMT- intima-media thickness) and functional (PWV - pulse wave velocity, SBP - systolic blood pressure, PP - pulse pressure) parameters of the large arterial damage and the mean blood flow velocity (CBFV) in middle cerebral...
Conference Abstract

92. P5.09 LIGHT EXERCISE CENTRAL SYSTOLIC LOADING IS INCREASED IN PATIENTS WITH CYSTIC FIBROSIS RELATED DIABETES

J.H. Hull, L. Ansley, C.E. Bolton, J.E. Sharman, R.K. Knight, D.J. Shale, J.R. Cockcroft, R. Garrod
Pages: 175 - 176
Background: As survival in the common autosomal recessive condition Cystic Fibrosis (CF) improves, there is focus on extra-pulmonary complications. Patients with CF have increased augmentation index (AIx) at rest which is greatest in those with diabetes (CFRD). We evaluated haemodynamic response to exercise,...
Conference Abstract

93. P5.10 CARDIOPULMONARY FITNESS AND ARTERIAL STIFFNESS IN HEALTHY SUBJECTS – IS THERE A DIFFERENCE BETWEEN ACUTE HAEMODYNAMIC EFFECTS OF AEROBIC VS. RESISTANCE EXERCISE?

C. O’Donovan, J. Hussey, J. Gormley, J. Feely, A. Mahmud
Pages: 176 - 176
Although, the cardioprotective effects of aerobic exercise are proven, not much is known about resistance exercise. Arterial wave reflection measured as augmentation index (AIx), and pulse pressure(PP) amplification are independent prognosticators of CV morbidity and mortality. However, how these parameters...
Conference Abstract

94. P5.11 THE AUTONOMIC NERVOUS SYSTEM FUNCTIONING IN PATIENTS WITH HUNTINGTON’S DISEASE

Z. Melik, K. Cankar, J. Kobal
Pages: 176 - 176
Background: Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder leading to progressive death of neurons in various brain regions. In advanced stages of disease there is a classical triad of movement, behavioural, and cognitive disorders. Besides there are often symptoms suggestive...
Conference Abstract

95. P2.01 INITIAL DATA ON THE NATURAL HISTORY OF APWV IN WEST AFRICAN INFANTS

J. Kips, O. Ayoola, S. Greenwald, W. Balogun, P. Clayton, L. Van Bortel, P. Segers, J.K. Cruickshank
Pages: 177 - 177
Introduction: Aortic pulse wave velocity (aPWV) may measure vascular structure and function (distensibility) more precisely than blood pressure (BP). Few data exist on arterial distensibility in infancy; none on the effects of malaria in African children. Methods: Healthy women with singleton pregnancies...
Conference Abstract

96. P2.02 THE METABOLIC SYNDROME IN MIDDLE AGED INDIVIDUALS IS ASSOCIATED WITH GREATER ELASTIC, BUT NOT MUSCULAR ARTERIAL STIFFNESS

V. Dzenkeviciute, L. Ryliskyte, Z. Petrulioniene, J. Badariene, A. Laucevicius
Pages: 177 - 177
There is some evidence that in MetS increase of arterial stiffness may be distributed over muscular and the elastic arteries not uniformly. The purpose of this study was to examine the association between the MS and arterial stiffness of both elastic and muscular arteries in middle aged individuals. Methods:...
Conference Abstract

97. P2.03 THE PLASMINOGEN ACTIVATOR INHIBITOR-1 (4G/5G) POLYMORPHISM AFFECTS CENTRAL ARTERIAL BLOOD PRESSURE IN WOMEN

H.M. Björck, P. Eriksson, U. Alehagen, L.U. Ljungberg, R. DeBasso, K. Persson, U. Dahlström, T. Länne
Pages: 177 - 178
Plasminogen activator inhibitor (PAI-1) is the key inhibitor of the fibrinolytic system, modulating cellular responses associated with vascular remodeling. Elevated plasma PAI-1 has been positively correlated to systolic- and diastolic blood pressure, measured in the brachial artery, and is increased...
Conference Abstract

98. P2.04 CALCIUM INTAKE IS INDEPENDENTLY ASSOCIATED WITH INCREASED AUGMENTATION INDEX: RESULTS FROM A CROSS-SECTIONAL FOLLOW-UP STUDY OF TWO RHEUMATOID ARTHRITIS COHORTS

S.A. Provan, K. Angel, A.G. Semb, D. Atar, T.K. Kvien
Pages: 178 - 178
Background: Population studies have indicated that both the presence of osteoporosis and serum levels of calcium are associated with an increased risk of cardiovascular disease. Objective: To investigate the association between bone loss, calcium intake and levels of the reactive hyperemia index (RHI)...
Conference Abstract

99. P2.05 CENTRAL HEMODYNAMIC PARAMETERS AND ARTERIAL STIFFNESS IN PAGET’S DISEASE

L. D’Elia, G. Mossetti, C.M. McEniery, D. Rendina, B.J. McDonnell, F. Galletti, P. Strazzullo
Pages: 178 - 178
Background: Paget’s disease of bone (PDB) is a common disorder characterised by increased, disorganised bone turnover in affected areas with overgrowth of immature woven bone. An increased cardiovascular risk has been reported in some studies of PDB, possibly related to arterial wall calcifications....
Conference Abstract

100. P2.06 ENDOTHELIAL DYSFUNCTION IS ASSOCIATED WITH ARTERIAL STIFFNESS IN HYPERTENSIVE PATIENTS WITH TYPE 2 DIABETES MELLITUS

R.M. Bruno, L. Ghiadoni, A.G. Daniele, G. Penno, F. Stea, L. Landini, G. Cartoni, S. Del Prato, S. Taddei, A. Salvetti
Pages: 178 - 178
Both endothelial dysfunction and arterial stiffness are considered as independent predictors of cardiovascular mortality, but their interrelationship has been poorly explored. Therefore we evaluated the relationship between endothelial function and pulse wave velocity (PWV) in essential hypertensive...
Conference Abstract

101. P2.07 MASKED HYPERTENSION IS “UNMASKED” BY LOW INTENSITY EXERCISE BLOOD PRESSURE

M.G. Schultz, M. Stowasser, J.L. Hare, T.H. Marwick, J.E. Sharman
Pages: 178 - 178
Background: Masked hypertension (MH) independently predicts mortality but cannot be diagnosed from clinic blood pressure (BP). We sought to determine if MH could be identified from BP or pressure waveform analysis (PWA) at rest or during low intensity exercise. Methodology: Brachial and estimated central...
Conference Abstract

102. P2.08 INTERRELATIONSHIPS BETWEEN METABOLIC SYNDROME, ERECTILE DYSFUNCTION AND EARLY ATHEROSCLEROSIS

N. Ioakeimidis, C. Vlachopoulos, G. Antoniou, K. Baou, D. Terentes-Printzios, A. Aggelis, I. Dima, P. Xaplanteris, G. Lazaros, C. Stefanadis
Pages: 179 - 179
Purpose: Men with metabolic syndrome (MetS) have an increased prevalence of erectile dysfunction (ED). Large artery stiffness is a marker of vascular wall changes associated with MetS. Aim of the study was to investigate associations between MetS, ED and changes in large artery properties. Methods:...
Conference Abstract

103. P2.09 INCREASED CAROTID INTIMA MEDIA THICKNESS AND WAVE REFLECTION IN PATIENTS WITH INTRACRANIAL ANEURYSMS

F. Santini, C. Morizzo, C. Martini, E. Malshi, M. Caniglia, M. Kozakova, G. Parenti, C. Palombo
Pages: 179 - 179
Background: whether or not the presence of intracranial aneurysms (IAs) is associated with alterations in systemic arteries is not known. Aim of the study was to evaluate morphology and distensibility of common carotid artery (CCA) in patients with IAs and in a control group of comparable age, gender...
Conference Abstract

104. P2.10 METABOLIC SYNDROME DOES NOT HAVE AN INDEPENDENT IMPACT ON ULTRASOUND INDICES OF PRECLINICAL CARDIOVASCULAR DISEASE

E. Malshi, C. Morizzo, M. Kozakova, C. Palombo
Pages: 179 - 179
Background: whether metabolic syndrome (MetS) has an independent impact on development of cardiovascular (CV) disease is uncertain. Aim: to evaluate indices of preclinical CV disease in subjects with MetS. Methods: we studied 160 subjects: 50 with MetS (ATP III criteria, age 49±12, BMI 36±7, 12 diabetics)...
Conference Abstract

105. P2.11 ASSESSING VENTRICULAR-VASCULAR INTERACTIONS IN GIRLS WITH TURNER SYNDROME: A PILOT STUDY

T.J. Bradley, C.S. O’Gorman, C. Slorach, M.K. Friedberg, L. Mertens, G.D. Wells, J. Hamilton
Pages: 179 - 179
Objectives: Women with Turner Syndrome (TS) have increased incidence of cardiovascular disease, thought to be related to a clustering of risk factors including insulin resistance, hypertension, obesity and dyslipidemia. The aim of this study was to non-invasively determine and compare ventricular and...
Conference Abstract

106. P2.12 THE ROLE OF INSULIN ON FUNCTION OF RESISTANCE ARTERIES FROM OBESE YOUNG WOMEN AT RISK OF ‘DIABETES’ AND CONTROLS

M. Banerjee, C. Austin, V. Charlton-Menys, W.F. Fraser, P. Pemberton, R.A. Malik, J.K. Cruickshank
Pages: 180 - 180
Objectives: Vascular dysfunction is common in type 2 diabetes and obesity. The functional role of hyperinsulinaemia on human blood vessels in obese individuals remains unclear. We hypothesised that in young women, change in vessel function in a hyperinsulinaemic milieu would be influenced more by adiposity...
Conference Abstract

107. P3.01 CAROTID ARTERY INTIMA-MEDIA COMPLEX INCREASE IN PATIENTS WITH METABOLIC SYNDROME AND DIFFERENT BRACHIAL ARTERY REACTIVITY DURING REACTIVE HYPERAEMIA TEST: 2 YEARS FOLLOW-UP RESULTS

V.V. Vikentyev, O.A. Polikina
Pages: 180 - 180
Patients having different risk factors for coronary heart disease (CHD), as well as those with metabolic syndrome, are known to have increased carotid artery (CA) intima-media complex thickness (IMT) index, comparing to healthy subjects. Recently, the significant correlation between IMT, changes in flow-mediated...
Conference Abstract

108. P3.02 GLUCOSE METABOLISM IMPAIRMENT IN METABOLIC SYNDROME IS LINKED WITH INCREASED PULSE WAVE VELOCITY

A.L. Lieber, C. Vesin, M.E. Safar, B.I. Levy, J. Blacher
Pages: 180 - 180
Introduction: Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors. The specificity of each component of metabolic syndrome improves its management. Objective: Do patients with MetS have arterial modifications? Which MetS components are they most closely linked to? Materials and methods:...
Conference Abstract

109. P3.03 IMPACT OF SMOKING ON ERECTILE FUNCTION AND ARTERIAL STIFFNESS IN MIDDLE-AGED SMOKERS WITHOUT OTHER MAJOR CARDIOVASCULAR RISK FACTORS

N. Ioakeimidis, C. Vlachopoulos, D. Terentes-Printzios, A. Aggelis, K. Baou, G. Antoniou, K. Rokkas, C. Stefanadis
Pages: 180 - 181
Purpose: Erectile dysfunction (ED) may be an early manifestation of generalized vascular disease. Cigarette smoking is an important modifiable cardiovascular risk factor and pathophysiological mechanisms may include a stiff vascular tree. The association of smoking with ED and functional changes in smokers...
Conference Abstract

110. P3.04 AORTIC STIFFNESS IS INDEPENDENTLY ASSOCIATED WITH WHITE COAT EFFECT

C.A. Taylor, L.A. Tomlinson, C.M. McEniery, I.B. Wilkinson
Pages: 181 - 181
Introduction: The difference between systolic blood pressure (SBP) measured in clinic and during the daytime phase of ambulatory BP measurement (ABPM) (Δclinic-day ABPM SBP) has been used as a measure of white-coat effect. We hypothesised that this was mediated through increased aortic stiffness resulting...
Conference Abstract

111. P3.05 ARTERIAL STIFFNESS MAY BE GREATER IN SOUTH ASIAN THAN AGE-MATCHED AFRICAN-CARIBBEAN MEN DESPITE SIMILAR PERIPHERAL OR CENTRAL BLOOD PRESSURE

R. Rezai, G. Goudot, J. Finn, F. Wu, JK. Cruickshank
Pages: 181 - 181
For given levels of blood pressure (BP), people with ‘stiffer’ (less distensible) large arteries develop more cardiovascular (CVS) events, as is typical of diabetes. South Asians (SA) develop excess mortality from all CVS disease, African-Caribbeans (AfC) lower overall mortality despite more hypertension...
Conference Abstract

112. P3.06 VASCULAR FUNCTION IN HIV-1 (SUBTYPE C) POSITIVE BLACK SOUTH AFRICANS WITH AND WITHOUT ARV TREATMENT: A THREE YEAR PROSPECTIVE STUDY

J.M. van Rooyen, C.M.T. Fourie, H.W. Huisman, R. Schutte, S. Péter, N.T. Malan, L. Malan, A. Kruger, A.E. Schutte
Pages: 181 - 181
The objective was to study the changes in vascular function of HIV-1 (subtype C) infected black Africans over three years. In a longitudinal study (2005–2008) we compared the vascular function of 140 HIV+ (newly diagnosed) black Africans from the North-West province, South Africa. Seventy seven of the...
Conference Abstract

113. P3.07 INCREASED ARTERIAL STIFFNESS IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE

J. Bellien, C. Freguin, M. Iacob, L. Kandil, C. Thuillez, M. Godin, R. Joannides
Pages: 182 - 182
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of renal cysts related to polycystin mutations in the tubular wall leading to renal failure. Moreover, patients with ADPKD also display early cardiovascular complications including hypertension and aneurysms before...
Conference Abstract

114. P3.08 EFFECTS OF REGULAR LEISURE EXERCISE ON ARTERIAL PRESSURE AUGMENTATION. THE MONICA/KORA AUGSBURG STUDY

M.R.P. Markus, J. Stritzke, W. Lieb, A. Luchner, A. Döring, U. Keil, H. Schunkert, H.W. Hense
Pages: 182 - 182
Background: Exercise influences pulse wave morphology, but the mechanisms are unknown. Methods: We measured radial arterial pulse wave contour (SphygmoCorR) in 1005 adults from a cohort follow-up examination in 2004/5 and compared individuals who, by self report, were sedentary (NPE, of less than one...
Conference Abstract

115. P3.09 IMPACT OF BIRTH WEIGHT ON BLOOD PRESSURE AND ARTERIAL STIFFNESS

K.L. Miles, B.J. McDonnell, J.R. Cockcroft, I.B. Wilkinson, C.M. McEniery
Pages: 182 - 182
Objective: Accumulating evidence suggests that low birth weight is associated with increased risk of future cardiovascular risk and increased systolic blood pressure. However the relationship between birth weight and arterial stiffness is controversial. We examined this relationship in the ENIGMA study,...
Conference Abstract

116. P3.10 PULSE WAVE VELOCITY AND AUGMENTATION INDEX ARE ASSOCIATED WITH 10-YEAR GENERAL CARDIOVASCULAR RISK AND HEART/VASCULAR AGE IN NEWLY DIAGNOSED, NEVER-TREATED HYPERTENSION

P. Xaplanteris, C. Vlachopoulos, G. Vyssoulis, I. Dima, D. Terentes-Printzios, N. Ioakeimidis, C. Stefanadis
Pages: 182 - 182
Background: The Framingham Heart Study group has proposed an algorithm for calculating the 10-year risk of developing cardiovascular disease (CVD) and heart/vascular age. The predictors used are age, diabetes, smoking, systolic blood pressure, total and high density cholesterol. We investigated the association...
Conference Abstract

117. P7.01 CAROTID ATHEROSCLEROSIS AND ENDOTHELIAL DISFUNCTION IN YOUNG AND MIDDLE-AGED MEN WITH CORONARY ARTERY DISEASE

T.V. Balakhonova, S.G. Kozlov, H.A. Mahmudova, A.A. Lyakishev, A.N. Rogoza
Pages: 183 - 183
Objective: To determine whether the structural status of carotid arteries and abnormal flow-mediated dilatation (FMD) in the brachial artery identify young and middle-aged men with coronary artery disease (CAD). Methods: A total of 78 men aged 28 to 50 (mean 43±5) years underwent carotid ultrasound...
Conference Abstract

118. P7.02 BEYOND BLOOD PRESSURE: IS ARTERIAL STIFFNESS MEASUREMENT THE FUTURE FOR PRIMARY CARE? A PILOT STUDY

A.H. Heald, S.G. Anderson, S. Macaleese, J.K. Cruickshank
Pages: 183 - 183
Background In primary care, much effort goes into risk factor management. Early recognition of vascular dysfunction in patients should inform intervention to reduce vascular risk. Very few studies have looked at the application of augmentation index (AI) measurement in primary care, particularly in...
Conference Abstract

119. P7.03 MARATHON RUNNERS HAVE INCREASED AORTIC STIFFNESS

D. Kardara, C. Vlachopoulos, A. Anastasakis, K. Baou, D. Terentes-Printzios, I. Dima, G. Antoniou, A. Gravos, C. Stefanadis
Pages: 183 - 184
Purpose: It is well known that regular moderate aerobic exercise has a beneficial effect on cardiovascular risk, although the impact of long-term intense aerobic training has not been defined. Aortic stiffness and wave reflections are independent predictors of cardiovascular risk. In this study we assessed...
Conference Abstract

120. P7.04 PROGRESSIVE ARTERIAL STIFFENING IN RENAL TRANSPLANT RECIPIENTS – RESULTS OF 28-MONTH FOLLOW-UP

P. Strózecki, A. Adamowicz, M. Kozlowski, Z. Wlodarczyk, J. Manitius
Pages: 184 - 184
Recent follow-up studies showed no change or even short-term improvement of arterial stiffness after kidney transplantation. Data from general population and end-stage renal disease patients suggest, that PWV increases with age of 0,07–0,08m/s for each year of life. It was shown recently that reduced...
Conference Abstract

121. P7.05 ASSOCIATION BETWEEN RENAL FUNCTION AND ARTERIAL STIFFNESS IN NEVER-TREATED HYPERTENSIVES

D. Terentes-Printzios, C. Vlachopoulos, N. Ioakeimidis, K. Aznaouridis, K. Baou, P. Pietri, N. Alexopoulos, I. Dima, A. Siama, C. Stefanadis
Pages: 184 - 184
Introduction: Hypertension and renal dysfunction are associated with increased arterial stiffness. Arterial stiffness is a marker of cardiovascular disease and predictor of cardiovascular risk. We assessed the relationship between renal function and arterial stiffness in never-treated hypertensives. Methods:...
Conference Abstract

122. P7.06 CENTRAL BLOOD PRESSURE AND AUGMENTATION INDEX OF HEALTHY YOUTH

E. Komonyi, Sz. Lengyel, M. Juhász, E. Katona, Gy Paragh, B. Fülesdi, J. Zatik, D. Páll
Pages: 184 - 184
Background: The clinical importance of central blood pressure (BP) and heart rate corrected augmentation index (AIxHR75) has been gradually increasing in recent years. Objectives: We measured the peripheral and central BP, the AIxHR75 of healthy volunteers with special regard to diurnal variation (8...
Conference Abstract

123. P3.11 INCREASED CAROTID PLAQUE OCCURRENCE IN MEN WITH THE FIBRILLIN-1 2–3 GENOTYPE

R. DeBasso, B. Hedblad, J. Carlson, G. Berglund, T. Länne
Pages: 183 - 183
Background: Fibrillin-1 is an important constituent of the vascular wall and earlier studies have indicated an effect of the fibrillin-1 2–3 genotype on blood pressure as well as aortic stiffness. The aim was to determine if the Fibrillin-1 2–3 genotype is associated with increased cardiovascular morbidity/mortality...
Conference Abstract

124. P7.07 IMPACT OF HYPERLEPTINEMIA ON ARTERIAL STIFFNESS IN A COMMUNITY POPULATION SAMPLE

K. Baou, C. Vlachopoulos, I. Dima, N. Ioakeimidis, P. Pietri, D. Terentes-Printzios, D. Kardara, G. Antoniou, C. Stefanadis
Pages: 185 - 185
Purpose: Leptin plays a regulatory role in body weight by controlling appetite and energy consumption. Elevated plasma leptin levels (hyperleptinemia) have been suggested to contribute to pathogenesis of diabetes, hypertension, atherosclerosis and coronary heart disease. Arterial stiffness is an independent...
Conference Abstract

125. P7.08 BIOCHEMICAL LIVER FUNCTION TESTS, ADIPOSE-TISSUE HORMONES AND CARDIOVASCULAR DISEASE TRADITIONAL AND NOVEL RISK PREDICTORS: INTIMATE RELATIONSHIPS

K. Baou, C. Vlachopoulos, N. Ioakeimidis, I. Dima, D. Terentes-Printzios, A. Siama, C. Stefanadis
Pages: 185 - 185
Purpose: Adipocytokines secreted by adipose tissue play an important role in the pathogenesis of atherosclerosis. Arterial stiffness represents an important novel risk factor of cardiovascular disease. We investigated the association between elevated serum alanine aminotransferase (ALT) levels, adipocytokines,...
Conference Abstract

126. P7.09 CORRELATION BETWEEN THE CENTRAL AND BRACHIAL BLOOD PRESSURE AND ASYMPTOMATIC CAROTID ATHEROSCLEROSIS

R. Böcskei, B. Benczúr, A. Cziráki, F. Molnár, M. Illyés
Pages: 185 - 185
Last year we presented that PWVao is a significant marker of early atherosclerosis. Now we were interested about how could the comparison of the central and brachial blood pressure predict the early atherosclerosis. The aim of this study was to analyze the relation between the central and brachial blood...
Conference Abstract

127. P7.10 ARTERIAL STIFFNESS IS A DETERMINANT OF INCREASED LEVELS OF AMINO TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDE – THE ROTTERDAM STUDY

J.H.W. Rutten, F.U.S. Mattace-Raso, G.C. Verwoert, J. Lindemans, A. Hofman, J.C.M. Witteman, A.H. van den Meiracker
Pages: 185 - 185
Objective: Arterial stiffness is one of the main determinants of the workload of the left ventricle. Amino-terminal pro B-type natriuretic peptide (NT-proBNP) is released by cardiomyocytes in response to left ventricular wall stress. The aim of this study was to investigate whether arterial stiffness...
Conference Abstract

128. P7.11 HIGH ANKLE-BRACHIAL INDEX IS ASSOCIATED WITH INCREASED AORTIC PULSE WAVE VELOCITY: THE CZECH POST-MONICA STUDY

P. Wohlfahrt, M. Ingrischová, D. Palouš, A. Krajcoviechová, J. Seidlerová, M. Dolejšová, M. Galovcová, J. Bruthans, V. Adámková, M. Jozífová, J. Filipovský, R. Cífková
Pages: 186 - 186
Ankle brachial index (ABI) has increasingly been used in general practice to identify patients with low ABI at high cardiovascular risk. However there is no consensus on the clinical significance of high ABI. The aim of our study was to compare large artery stiffness as a marker of cardiovascular risk...
Conference Abstract

129. P7.12 ARTERIAL STIFFNESS IN PATIENTS WITH HEART FAILURE OF ISCHEMIC AND NON-ISCHEMIC AETIOLOGY

Y. Osmolovskaya, A. Glechan, A. Skvortsov, V. Mareev
Pages: 186 - 186
Increased arterial stiffness abnormal ventricular-vascular coupling have increasingly been recognized as playing an important pathophysiologic role in HF, both systolic and with normal ejection fraction. Aim: to assess and compare arterial stiffness, central blood pressure parameters in systolic heart...
Conference Abstract

130. P7.13 THE P22PHOX -640A/G POLYMORPHISM OF NADPH OXIDASE ADVERSELY AFFECTS ENDOTHELIN LEVELS BUT NOT PERIPHERAL AND CENTRAL PRESSURES IN HEALTHY, YOUNG, NORMOTENSIVE INDIVIDUALS

P. Xaplanteris, C. Vlachopoulos, C. Vassiliadou, K. Baou, I. Dima, D. Kardara, C. Stefanadis
Pages: 186 - 186
Purpose: The NADPH oxidase system produces superoxide in the vessel wall and its -640A/G polymorphism is associated with coronary artery disease incidence in young individuals. We investigated the role of this polymorphism on peripheral/aortic pressures (PP, AoP), and endothelin-1 (ET-1) levels, in young...
Conference Abstract

131. P8.01 PREDICTORS OF AORTIC STIFFENING IN ELDERLY SUBJECTS: RESULTS OF A NINE-YEAR FOLLOW-UP

J. Seidlerová, J. Filipovský, O. Mayer, M. Dolejšová
Pages: 186 - 186
Objective: To investigate predictors of increase in aortic pulse wave velocity (aPWV) in elderly subjects free from overt cardiovascular disease. Design and Method: The present study included 90 lecture attendees (“university of 3rd age”) who were examined at baseline and after a median follow-up of...
Conference Abstract

132. P8.02 IMPACT OF TRIGLYCERIDES AND INSULIN LEVELS ON WHOLE AND SURFACE CAROTID PLAQUE COMPOSITION IN PATIENTS WITH METABOLIC SYNDROME

S.A. Gonzalez, P.J. Forcada, D. Olano, E. Cavanagh, S. Obregon, C. Castelaro, C. Kotliar
Pages: 187 - 187
Introduction: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities strongly associated with atherosclerosis and increased risk of CV events. Atherosclerotic plaques (AP) and its echolucency (ECL) can be detected using ultrasound (US) and evaluated by grey scale median analysis (GSM). ECL...
Conference Abstract

133. P8.03 INCREASED ARTERIAL STIFFNESS IN WOMEN WITH RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS IS NOT ASSOCIATED WITH LEVEL OF C-REACTIVE PROTEIN

A. Cypiene, A. Venalis, L. Ryliskyte, J. Dadoniene, Z. Petrulioniene, M. Kovaite, R. Rugiene, A. Laucevicius
Pages: 187 - 187
Introduction: The elevated level of C reactive protein (CRP) is associated with increased arterial stiffness in general population. However, it is uncertain whether CRP is related to arterial stiffness in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Methods: We studied 63 RA women...
Conference Abstract

134. P8.04 ARTERIAL FUNCTION AND INSULIN SENSITIVITY: THEIR INTERPLAY IN EUGLYCAEMIC, NEVER-TREATED HYPERTENSIVES

P. Xaplanteris, C. Vlachopoulos, G. Vyssoulis, G. Antoniou, C. Stefanadis
Pages: 187 - 187
Background: Insulin resistance is a feature of essential hypertension. The interrelationships of indices of insulin resistance and arterial function in euglycaemic, never-treated hypertensives has not been addressed. To this end, we investigated the correlations of two insulin resistance indices (HOMA:...
Conference Abstract

135. P8.05 DIABETES CONTROL QUALITY IS AN INDEPENDENT FACTOR OF ARTERIAL WALL RIGIDIFICATION

A.L. Lieber, C. Vesin, M.E. Safar, B.I. Levy, J. Blacher
Pages: 187 - 188
Introduction: Arterial tree alteration is the cornerstone of diabetes complications and its mechanical parameters are impaired. Objective: Which are aortic pulse wave velocity determinants in a diabetic population? Methods: We studied 132 diabetic patients. They entered the day hospital to have a cardiovascular...
Conference Abstract

136. P8.06 REFERENCE VALUES FOR ARTERIAL STIFFNESS MEASURED WITH ARTERIOGRAPH

B. Benczúr, R. Böcskei, M. Illyés
Pages: 188 - 188
Elevated aortic pulse wave velocity (aoPWV) is an independent predictor of cardiovascular morbidity and mortality. There are, however, no widely accepted normal or reference values for aoPWV. The aim of this work was to define these values. Patients and methods: AoPWV was assessed in several patient...
Conference Abstract

137. P8.07 AN OLD DOG WITH NEW TRICKS: URIC ACID LEVELS ARE ASSOCIATED WITH AORTIC STIFFNESS AND WAVE REFLECTIONS IN NEWLY DIAGNOSED, NEVER-TREATED HYPERTENSION

P. Xaplanteris, C. Vlachopoulos, G. Vyssoulis, I. Dima, K. Baou, K. Aznaouridis, N. Alexopoulos, C. Stefanadis
Pages: 188 - 188
Background: Serum uric acid (UA) plays a key role in the development and progression of hypertension. We investigated the association of UA levels and indices of arterial function in a cohort of newly diagnosed, never treated hypertensive subjects. Methods: 1225 patients with a new diagnosis of mild...
Conference Abstract

138. P8.08 HEMODYNAMICS AND LARGE ARTERY STIFFNESS IN YOUNG PREHYPERTENSIVE MEDICAL STUDENTS

B. van den Bogaard, C. Spaan, K. Lieve, G.A. van Montfrans, B.J.H. van den Born
Pages: 188 - 188
Background: Prehypertensive subjects have a markedly increased risk of developing hypertension compared to normotensive subjects. Prehypertension is therefore an excellent model to study hemodynamics and arterial stiffness in the development of hypertension. Methods: We assessed hemodynamics and arterial...
Conference Abstract

139. P8.09 C-REACTIVE PROTEIN IS ASSOCIATED WITH ENDOTHELIUM-DEPENDENT ALTERATIONS OF MICROCIRCULATION IN PATIENTS WITH METABOLIC SYNDROME

L. Ryliskyte, J. Badariene, V. Dzenkeviciute, A. Cypiene, V. Skorniakov, A. Laucevicius
Pages: 188 - 189
Objective: Inflammation and early arterial damage are the possible mechanisms responsible for increased cardiovascular risk (CVR) in patients with metabolic syndrome (MetS). The aim of this study was to investigate the relationship between C-reactive protein (CRP) and arterial parameters of macro- and...
Conference Abstract

140. P8.10 THE RELATIONSHIP BETWEEN AUGMENTATION INDEX AND AGEING: A META-REGRESSION ANALYSIS

A.J. Baksi, T.A. Treibel, J.E. Davies, N. Hadjiloizou, R.A. Foale, K.H. Parker, D.P. Francis, J. Mayet, A.D. Hughes
Pages: 189 - 189
It has been reported that augmentation index (AIx) increases with age, but that the increase is more prominent in younger subjects [1], and may even decrease with age in individuals over 50yrs [2]. We undertook a meta-analysis of the published literature of 9,551 individuals (5,659 male), aged 4 to 91...
Conference Abstract

141. P8.11 SUPINE CLINIC BLOOD PRESSURE IS RAISED IN HYPERTENSIVE NON-DIPPERS: A NOVEL TEST TO DETERMINE DIPPER STATUS?

C.T. Coleman, D. Gilroy, L. Wright, M. Stowasser, J.E. Sharman
Pages: 189 - 189
Introduction: Patients with nocturnal blood pressure (BP) that fails to decline ≥10% compared with daytime BP (non-dippers) have increased mortality risk. This may be related to increased arterial stiffness and raised central BP whilst supine. This study aimed to test this hypothesis. We also sought...
Conference Abstract

142. P8.12 ASSOCIATION BETWEEN ASYMMETRIC DIMETHYLARGININE AND THE INDICES OF VASCULAR FUNCTION IN PATIENTS WITH ESSENTIAL HYPERTENSION

M. Sergejev, M. Zagura, P. Kampus, J. Kals, P. Muda, T.P. Tuomainen, K. Zilmer, M. Zilmer, J. Eha
Pages: 189 - 189
Background: Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide production and is associated with endothelial dysfunction. Elevated plasma levels of ADMA have been demonstrated in patients with hypertension. The aim of the present study was to investigate the relationship between ADMA...
Conference Abstract

143. P8.13 CORONARY IMPLANTATION OF SIROLIMUS-ELUTING STENT IMPAIRS THE PERIPHERAL VASCULAR COMPLIANCE IN PATIENT WITH CORONARY ARTERY DISEASE

M. Vatrano, R. Ceravolo, C. Nesta, A. Ferraro, E. Campopiano, F. Borrello, V. Pascale, G. Ciconte, V.A. Ciconte
Pages: 189 - 190
Introduction: To the best of our knowledge, any studies evaluated potential influence on peripheral arterial stiffness, measured by pulse wave velocity (PWV), of percoutaneous coronary intervention (PCI) and stenting. Methods: 150 patients were enrolled and underwent coronary angiography. In 68 patients...
Conference Abstract

144. P10.01 INVOLVEMENT OF CALCIUM-CALMODULIN DEPENDENT PROTEIN KINASE II ON ENDOTHELIN RECEPTOR EXPRESSION IN CEREBRAL ARTERIES OF RAT

R. Waldsee, H. Ahnstedt, S. Eftekhari, L. Edvinsson
Pages: 191 - 191
Background. Experimental cerebral ischemia and organ culture of cerebral arteries result in enhanced expression of endothelin ETB receptors in smooth muscle cells. The present study was designed to evaluate the involvement of calcium-calmodulin dependent protein kinase (CAMK) on the expression of endothelin...
Conference Abstract

145. P10.02 EFFECT OF INTEGRIN-EXTRACELLULAR MATRIX INTERACTIONS ON SMALL ARTERY STRUCTURE AND MECHANICS DURING HYPERTENSION AND AGING

K.R. Parmar, E.H. Heerkens, A.M. Heagerty
Pages: 191 - 191
An age-related increase in systolic blood pressure and similarities in the consequences of hypertension and aging on arterial structure/mechanics have been reported, particularly in larger arteries. As the structural/mechanical properties of smaller resistance vessels in the context of advancing physiological...
Conference Abstract

146. P10.03 ENDOTHELIUM-SPECIFIC CALCIUM-ACTIVATED POTASSIUM CHANNELS: TARGETS FOR ALDOSTERONE

V. Griol-Charhbili, A. Nguyen Dinh Cat, G. Palais, L. Loufrani, D. Henrion, N. Farman, F. Jaisser
Pages: 191 - 191
To define the vascular role of the mineralocorticoid receptor (MR) in cardiovascular pathophysiology, we generated a conditional transgenic mouse model with MR overexpression in the endothelium. We previously described increase sensitivity to several vasoconstrictors in mesenteric arteries such as in...
Conference Abstract

147. P10.04 INFLUENCE OF 1,25(OH)2D3 (VITAMIN D) ON RESISTANCE ARTERY CONTRACTILITY

G. Goudot, M. Rezai, J.K. Cruickshank
Pages: 191 - 192
Low serum vitamin D is linked with higher vascular risk. It is unclear how. Objective: to test whether 1,25(OH)2D3 (active vitamin D) modifies contractility of proximal resistance vessels, dose-dependently. Methods: Male Wistar rat mesenteric arteries were investigated by wire myography. 60mM High...
Conference Abstract

148. P10.05 REDUCED MOLECULAR FLEXIBILITY IN THE LARGE ARTERIES OF DIABETIC RATS

R. Akhtar, N. Gardiner, J.K. Cruickshank, B. Derby, M.J. Sherratt
Pages: 192 - 192
In Type 1 and 2 diabetes tissue stiffening is evident from measurements of the gross mechanical properties of the vasculature. In general, pathological glycosylation of extracellular matrix proteins may play an important role in increasing stiffness in diabetic patients. However, the effects of diabetes...
Conference Abstract

149. P10.06 ABNORMAL VASCULAR PROGRAMMING OF ACID ARACHIDONIC METABOLISM COULD EXPLAIN HYPERTENSION IN RATS EXPOSED IN UTERO TO MATERNAL DIABETES

C. Fassot, J.P. Duong Van Huyen, E. Vessieres, C. Perret, S. Laurent, D. Henrion, M. Lelièvre- Pégorier
Pages: 192 - 192
Epidemiologic studies have clearly demonstrated that cardiovascular risk is not only determined by conventional risk factors of importance in adult life, but also by early life events resulting of re-settings of key physiological functions. In our model of rats exposed in utero to maternal diabetes,...
Conference Abstract

150. P10.07 A PPG MEASUREMENT SETUP AND PULSE WAVE ANALYSIS FOR ARTERIAL STIFFNESS

M.J. Huotari, K. Maatta, J. Kostamovaara
Pages: 192 - 192
The light energy absorption of whole blood in the visible and infrared range is partly caused by the oxidized and reduced haemoglobin. The measurement principle can be applied for photoplethysmography (PPG). Our PPG measures the blood flux in human vessels with means of red and infrared light absorption....
Conference Abstract

151. P10.08 PULMONARY ARTERY CALCIFICATION IN RACEHORSES

L.G. Arroyo, M.A. Hayes, L. Viel
Pages: 192 - 192
Vascular calcification (VC) has been sporadically reported in horses, but little is known regarding cause, pathogenesis and clinical significance. We hypothesized that in horses, structural and molecular changes may occur during VC that are comparable to human and mouse models. We surveyed Thoroughbred...