P3.01 CAROTID ARTERY INTIMA-MEDIA COMPLEX INCREASE IN PATIENTS WITH METABOLIC SYNDROME AND DIFFERENT BRACHIAL ARTERY REACTIVITY DURING REACTIVE HYPERAEMIA TEST: 2 YEARS FOLLOW-UP RESULTS

DOI

10.1016/j.artres.2009.10.030How to use a DOI?

Abstract

Patients having different risk factors for coronary heart disease (CHD), as well as those with metabolic syndrome, are known to have increased carotid artery (CA) intima-media complex thickness (IMT) index, comparing to healthy subjects. Recently, the significant correlation between IMT, changes in flow-mediated dilatation (FMD) of the brachial artery (BA), different CHD risk factors and such important components of metabolic syndrome (MS), as insulin resistance and hyperglycaemia was shown. Nevertheless, the relationship between IMT and FMD and their role in atherogenesis are still ill defined.

Our aim was to investigate the dynamics of IMT and number of newly found CA atherosclerotic plaques (ASP) in patients with normal and lowered FMD.

Study group comprised of 89 men with lowered FMD (less then 5%) and 92 men with normal FMD (more, then 5%), 31–52 years of age. All the participants have undergone clinical examination according to standardized protocol, including physical examination. Blood samples for lipid profile and glucose levels were taken. Using high definition ultrasound IMT was measured and CA ultrasound scan was performed.

Results: at two-years follow-up in patients with initially lowered FMD the IMT increase was significantly higher, then in those with normal FMD at baseline (delta S=5.39% vs 1.12%, p=0.0001, respectively). In the group with initially lowered FMD number of newly found ASP was 31 (34.8%), whereas in group with initially normal FMD there were only twelve new cases (13%).

Conclusions: there is a positive correlation between initially impaired (lowered) FMD and increased IMT and higher number of new ASPs in the CA after two years follow-up.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - V.V. Vikentyev
AU  - O.A. Polikina
PY  - 2009
DA  - 2009/12/03
TI  - P3.01 CAROTID ARTERY INTIMA-MEDIA COMPLEX INCREASE IN PATIENTS WITH METABOLIC SYNDROME AND DIFFERENT BRACHIAL ARTERY REACTIVITY DURING REACTIVE HYPERAEMIA TEST: 2 YEARS FOLLOW-UP RESULTS
JO  - Artery Research
SP  - 180
EP  - 180
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.030
DO  - 10.1016/j.artres.2009.10.030
ID  - Vikentyev2009
ER  -