Artery Research

Volume 3, Issue 4, December 2009, Pages 155 - 155

5.1 ASSESSMENT OF THE ARTERIAL WALL BEHAVIOR ALONG THE COMMON CAROTID ARTERY AT THE LEVEL OF A PLAQUE ACCORDING TO ARTERIAL STIFFNESS GRADIENT

Authors
H. Beaussier1, I. Masson2, O. Naggara3, D. Calvet3, R. Joannides4, E. Guegan-Massardier4, E. Gérardin4, E. Bozec1, P. Boutouyrie1, S. Laurent1
1Department of Pharmacology and INSERM URMS 872, Hôpital Européen Georges Pompidou, Paris, France
2Institut d’Alembert, UMR CNRS 7190, Université Pierre et Marie Curie and UMR CNRS 7054, Paris, France
3Departments of Neurology and Neuroradiology, EA 4055 Centre Hospitalier Sainte-Anne, Paris, France
4Departments of Pharmacology and Neurology and INSERM URM 644, CHU Rouen, Paris, France
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.159How to use a DOI?
Abstract

Background: We previously described longitudinal strain gradient named bending strain (BS), along the common carotid artery (CCA) with two distinct patterns (Paini, Stroke 2007, Beaussier, Hypertension 2008): Pattern A (larger radial strain at the plaque level than at adjacent CCA) and its opposite, Pattern B.

Aim: To assess the role of change in CCA thickness (IMT) and medial diameter (D) during the cardiac cycle at the level of plaques according to functional patterns of BS.

Method: 45 CCA were analysed at the level of the plaque in 26 patients. Mechanical parameters were measured at 128 sites on a 4 cm long CCA segment by an echotracking system (ArtLab®). Plaque composition was determined by magnetic resonance imaging (MRI). For each plaque, systolo(s)-diastolic(d) variation of IMT and D were calculated. We obtained ΔIMT ((IMTs - IMTd)/IMTd), ΔDiameter ((Ds - Dd)/Dd) and ratio R (ΔIMT/ΔD).

Results: R did not significantly differ according to remodeling pattern neither to plaque composition. Plaques exhibiting Pattern B (n=25) were characterized by an R 73 % higher than plaques exhibiting Pattern A (n=20) (5.9 ± 3.0 versus 3.4 ± 1.6, p<0.005). In other words, IMT strain is disproportionately larger than diameter strain among Pattern B than among pattern A.

Conclusion: The arterial stiffness gradient at the level of the plaque may influence the arterial wall behavior: an inward BS may be associated with exaggerated compressibility and local stresses within the wall in comparison to an outward BS with reduced local stresses.

Open Access
This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

Journal
Artery Research
Volume-Issue
3 - 4
Pages
155 - 155
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.159How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - H. Beaussier
AU  - I. Masson
AU  - O. Naggara
AU  - D. Calvet
AU  - R. Joannides
AU  - E. Guegan-Massardier
AU  - E. Gérardin
AU  - E. Bozec
AU  - P. Boutouyrie
AU  - S. Laurent
PY  - 2009
DA  - 2009/12/03
TI  - 5.1 ASSESSMENT OF THE ARTERIAL WALL BEHAVIOR ALONG THE COMMON CAROTID ARTERY AT THE LEVEL OF A PLAQUE ACCORDING TO ARTERIAL STIFFNESS GRADIENT
JO  - Artery Research
SP  - 155
EP  - 155
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.159
DO  - 10.1016/j.artres.2009.10.159
ID  - Beaussier2009
ER  -