P8.13 CORONARY IMPLANTATION OF SIROLIMUS-ELUTING STENT IMPAIRS THE PERIPHERAL VASCULAR COMPLIANCE IN PATIENT WITH CORONARY ARTERY DISEASE

DOI

10.1016/j.artres.2009.10.119How to use a DOI?

Abstract

Introduction: To the best of our knowledge, any studies evaluated potential influence on peripheral arterial stiffness, measured by pulse wave velocity (PWV), of percoutaneous coronary intervention (PCI) and stenting.

Methods: 150 patients were enrolled and underwent coronary angiography. In 68 patients was performed coronary stenting (PCI group). PWV was invasively obtained before and after coronary stenting.

Results: Coronary stenting produced a significant augment of PWV (from 4.59 to 5.82m/s, P=0.000). In contrast, the sub-population which performed angiography without PCI (noPCI group), didn’t show any significant change in PWV. The analysis of PCI group demonstrated that only implantation of Sirolimus eluting stent (SES) caused a significant increase of PWV (from 4.62 to 6.15m/s, P=0.029). In a stepwise multiple regression model stent length, glycaemia and body mass index were significantly associated with increase of PWV, accounting for a total of 51.7% of the variation (P=0.009). In particular, stent length accounted for 39.6% of the variance in PWV augmentation; glycaemia and body mass index explained an additional 12.1% of its variability. In the same analysis performed in PCI group, stent length accounted for 65.3% of the variance (P=0.024) and other than glycaemia and body mass index, also implantation of SES explained an additional 18.5%.

Conclusion: We have shown, for the first time, a significant association between SES implantation and an central stiffness worsening.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - M. Vatrano
AU  - R. Ceravolo
AU  - C. Nesta
AU  - A. Ferraro
AU  - E. Campopiano
AU  - F. Borrello
AU  - V. Pascale
AU  - G. Ciconte
AU  - V.A. Ciconte
PY  - 2009
DA  - 2009/12/03
TI  - P8.13 CORONARY IMPLANTATION OF SIROLIMUS-ELUTING STENT IMPAIRS THE PERIPHERAL VASCULAR COMPLIANCE IN PATIENT WITH CORONARY ARTERY DISEASE
JO  - Artery Research
SP  - 189
EP  - 190
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.119
DO  - 10.1016/j.artres.2009.10.119
ID  - Vatrano2009
ER  -