Artery Research

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Volume 3, Issue 4, December 2009, Pages 172 - 172

P4.09 EFFECT OF VARDENAFIL ON ARTERIAL STIFFNESS AND WAVE REFLECTION

Authors
D. Terentes-Printzios, C. Vlachopoulos, N. Ioakeimidis, K. Rokkas, K. Aznaouridis, K. Baou, C. Stefanadis
1st Department of Cardiology, Athens Medical School, Hippokration General Hospital, Athens, Greece
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.050How to use a DOI?
Abstract

Introduction: While vardenafil is widely prescribed for erectile dysfunction, its effect on arterial function is not established. Arterial stiffness and wave reflections are markers of cardiovascular disease and predictors of cardiovascular risk. We assessed the acute effect of vardenafil on arterial stiffness and wave reflections on patients with erectile dysfunction.

Methods: Ten patients (mean age 58±10 years) with erectile dysfunction received vardenafil 20mg in a randomized, placebo-controlled, double-blind, 2-way cross-over design. Aortic elastic properties were evaluated with carotid-femoral pulse wave velocity (cfPWV); wave reflection was evaluated with augmentation index (AIx) of the aortic pressure waveform. cfPWV and wave reflection indices were measured at baseline and for 3hours after the vardenafil intake or placebo.

Results: cfPWV decreased significantly (by 0.502m/s, p <0.01), denoting a decrease in aortic stiffness. AIx decreased significantly (by 3.11%, p <0.01), denoting a decreased effect of wave reflection from the periphery. Aortic pulse pressure decreased significantly (by 5.09 mmHg, p <0.01). The effect of vardenafil lasted throughout the study (3hours), being evident 30 to 60minutes after drug intake.

Conclusion: This study shows, for the first time, that vardenafil has a favorable effect on aortic stiffness and wave reflection in patients with erectile dysfunction.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
3 - 4
Pages
172 - 172
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.050How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - D. Terentes-Printzios
AU  - C. Vlachopoulos
AU  - N. Ioakeimidis
AU  - K. Rokkas
AU  - K. Aznaouridis
AU  - K. Baou
AU  - C. Stefanadis
PY  - 2009
DA  - 2009/12/03
TI  - P4.09 EFFECT OF VARDENAFIL ON ARTERIAL STIFFNESS AND WAVE REFLECTION
JO  - Artery Research
SP  - 172
EP  - 172
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.050
DO  - 10.1016/j.artres.2009.10.050
ID  - Terentes-Printzios2009
ER  -