Artery Research

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Volume 3, Issue 4, December 2009, Pages 173 - 174

P5.01 THE EFFECT OF PULMONARY REHABILITATION ON ARTERIAL STIFFNESS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Authors
N.S. Gale1, J.M. Duckers2, D. Proud3, T. Lines3, S. Enright1, J.R. Cockcroft4, D.J. Shale2, C.E. Bolton2
1School of Healthcare Studies, Cardiff University, Cardiff, United Kingdom
2Department of Respiratory Medicine, Cardiff University, Cardiff, United Kingdom
3Pulmonary Rehabilitation Department, Llandough Hospital, Cardiff, United Kingdom
4Wales Heart Research Institute, Cardiff University, Cardiff, United Kingdom
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.056How to use a DOI?
Abstract

Background: We have previously shown increased arterial stiffness using aortic pulse wave velocity (PWV) in patients with COPD. Pulmonary rehabilitation (PR) (exercise, education and nutritional advice) has respiratory and functional benefits, though effects on cardiovascular (CV) risk have not been explored. We hypothesised PWV would improve with PR.

Methods: 22 (8 male) clinically stable patients, free from overt CV disease had BP, PWV, spirometry (FEV1), shuttle walk (ISWT) and fasting glucose and lipids performed pre and post PR. 20 age and gender matched controls were studied for baseline comparison.

Results: Median (range) age for patients was 62.5 (54–79) years, mean (SD) FEV1 was 44.9 (15.6)% predicted. Aortic PWV, cholesterol and BP reduced with PR. 3 of 11 patients no longer met the criteria for hypertension. The fall in aortic PWV was attributable to the fall in BP.

Conclusions: PR improves the haemodynamic profile of subjects with COPD. Longer term CV effects of PR should now be investigated.

Mean (SD) Control COPD - Pre PR COPD - Post PR
Aortic PWV (m/sec) 8.5 (1.4) 9.82 (3.0)† 9.26 (2.7)*
Systolic BP (mmHg)§ 130.0 (15.9) 137.6 (20.0) 127.9 (23.6)**
Diastolic BP (mmHg)§ 78.7 (8.4) 82.8 (9.5) 78.4 (11.8)**
MAP (mmHg)§ 96.0 (10.0) 100.9 (11.9) 94.9 (14.1)**
Heart Rate (bpm) 67.8 (11.0) 76.1 (12.1)†† 75.9 (14.1)
Cholesterol (mmol/L) 5.2 (1.2) 5.6 (1.2) 5.4 (1.2)*
Glucose (mmol/L) 5.2 (0.5) 5.0 (0.7) 4.8 (0.8)
ISWT (m) - 190.4 (69.8) 273.6 (75.5)**
§

Peripheral pressures;

†

p<0.05;

††

p<0.001 difference from controls.

*

p<0.05;

**

p<0.001 difference with PR.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
3 - 4
Pages
173 - 174
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.056How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - N.S. Gale
AU  - J.M. Duckers
AU  - D. Proud
AU  - T. Lines
AU  - S. Enright
AU  - J.R. Cockcroft
AU  - D.J. Shale
AU  - C.E. Bolton
PY  - 2009
DA  - 2009/12/03
TI  - P5.01 THE EFFECT OF PULMONARY REHABILITATION ON ARTERIAL STIFFNESS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
JO  - Artery Research
SP  - 173
EP  - 174
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.056
DO  - 10.1016/j.artres.2009.10.056
ID  - Gale2009
ER  -