P8.03 INCREASED ARTERIAL STIFFNESS IN WOMEN WITH RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS IS NOT ASSOCIATED WITH LEVEL OF C-REACTIVE PROTEIN

A. Cypiene; A. Venalis; L. Ryliskyte; J. Dadoniene; Z. Petrulioniene; M. Kovaite; R. Rugiene; A. Laucevicius

doi:10.1016/j.artres.2009.10.109

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Volume 3, Issue 4, December 2009, Pages 187 - 187

P8.03 INCREASED ARTERIAL STIFFNESS IN WOMEN WITH RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS IS NOT ASSOCIATED WITH LEVEL OF C-REACTIVE PROTEIN

Authors

A. Cypiene¹, A. Venalis², L. Ryliskyte¹, J. Dadoniene², Z. Petrulioniene¹, M. Kovaite¹, R. Rugiene², A. Laucevicius¹

¹Centre of Cardiology and Angiology Vilnius University Hospital Santariškiu Klinikos, Vilnius, Lithuania

²Institute of Experimental and Clinical medicine at Vilnius University, Vilnius, Lithuania

Available Online 3 December 2009.

DOI: 10.1016/j.artres.2009.10.109 How to use a DOI?
Abstract: Introduction: The elevated level of C reactive protein (CRP) is associated with increased arterial stiffness in general population. However, it is uncertain whether CRP is related to arterial stiffness in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).

Methods: We studied 63 RA women (aged 41.48±10.77 years) with disease activity (DAS28) 5.43±0.93, 31 SLE (aged 37.23±9.09 years), disease activity index (SLEDAI) 18.40±8.17, organ damage index (SLICC) 1.0 (IQR 2.0) and 72 controls (aged 37.42±9.15). Blood tests included serum lipid profile, glucose and high-sensitivity CRP (hsCRP) measurement. The augmentation index (AIx), the measure of systemic arterial stiffness, was assessed by applanation tonometry (Sphygmocor v.7.01, AtCor Medical).

Results: In RA patients CRP (mg/l) was significantly higher as compared to SLE and controls (31.89±40.44 vs. 5.80±5.56 vs. 1.64±3.18; p<0.001), but it was not related to AIx. AIx was 24.71±11.52% in RA vs. 20.81±12.29% in SLE and 13.24±10.44% in controls; p<0.001. Significant influence of mean blood pressure (MBP) on arterial stiffness (AIx) was observed in RA patients (r2adj.=0.365; p<0.001). In SLE patients MBP, SLICC and age were significant predictors of AIx (r2adj.=0.508; p<0.001).

Conclusion: Elevated CRP is present in RA and SLE, but it is not related to increased systemic arterial stiffness. Significant influence of MBP on arterial stiffness (AIx) was observed in RA patients. In SLE patients MBP, SLICC and age were related to increased AIx.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 3 - 4
Pages: 187 - 187
Publication Date: 2009/12/03
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2009.10.109 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - A. Cypiene
AU  - A. Venalis
AU  - L. Ryliskyte
AU  - J. Dadoniene
AU  - Z. Petrulioniene
AU  - M. Kovaite
AU  - R. Rugiene
AU  - A. Laucevicius
PY  - 2009
DA  - 2009/12/03
TI  - P8.03 INCREASED ARTERIAL STIFFNESS IN WOMEN WITH RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS IS NOT ASSOCIATED WITH LEVEL OF C-REACTIVE PROTEIN
JO  - Artery Research
SP  - 187
EP  - 187
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.109
DO  - 10.1016/j.artres.2009.10.109
ID  - Cypiene2009
ER  -

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