P8.09 C-REACTIVE PROTEIN IS ASSOCIATED WITH ENDOTHELIUM-DEPENDENT ALTERATIONS OF MICROCIRCULATION IN PATIENTS WITH METABOLIC SYNDROME

L. Ryliskyte; J. Badariene; V. Dzenkeviciute; A. Cypiene; V. Skorniakov; A. Laucevicius

doi:10.1016/j.artres.2009.10.115

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Volume 3, Issue 4, December 2009, Pages 188 - 189

P8.09 C-REACTIVE PROTEIN IS ASSOCIATED WITH ENDOTHELIUM-DEPENDENT ALTERATIONS OF MICROCIRCULATION IN PATIENTS WITH METABOLIC SYNDROME

Authors

L. Ryliskyte¹, J. Badariene¹, V. Dzenkeviciute¹, A. Cypiene¹, V. Skorniakov², A. Laucevicius¹

¹Vilnius University Hospital Santariskiu Klinikos, Center of Cardiology and Angiology, Vilnius University, Vilnius, Lithuania

²Vilnius University, Faculty of Mathematics, Vilnius, Lithuania

Available Online 3 December 2009.

DOI: 10.1016/j.artres.2009.10.115 How to use a DOI?
Abstract: Objective: Inflammation and early arterial damage are the possible mechanisms responsible for increased cardiovascular risk (CVR) in patients with metabolic syndrome (MetS). The aim of this study was to investigate the relationship between C-reactive protein (CRP) and arterial parameters of macro- and microcirculation in MetS patients.

Methods: Subjects with MetS but without overt cardiovascular disease (n=100; age 52.9±6.4; 40% male) underwent detailed assessment of CVR factors. Measurements of local, regional and systemic arterial stiffness (AS) and endothelial function (EF) in brachial artery, finger and skin were performed.

Results: Subjects were categorized according to CRP levels that relate to future CVR (<1, 1–3, and >3mg/L). There was no significant difference in the mean age (51.2±5.3, 53.6±6.6 and 53.6±7.2, p=0.19) and gender distribution (p=0.44) between the CRP categories. However, body mass index and waist circumference differed as did mean arterial pressure (p<0.001, p=0.001 and p=0.016 respectively). Carotid AS (2.86±1.09; 3.49±1.52; 3.77±1.68, p=0.028) and several parameters of EF assessed by laser Doppler in microcirculation, e.g. percent change of skin perfusion (5090±2385; 3636±1777; 3885±2731 %, p=0.033) and time to half before hyperaemia (9.76±15.10; 4.51±8.04; 3.47±5.69 s, p=0.036), were significantly related to CRP category (Kruskal-Wallis Test). Multiple regression analysis revealed that CRP is independently associated only with alterations in microcirculation – percent change of skin perfusion (rest-to-peak flow, beta=0.27, p=0.016) but not other arterial parameters.

Conclusion: In MetS patients CRP is independent predictor of endothelium-dependent alterations in skin microcirculation. Association between CRP categories and other parameters of microcirculation and carotid arterial stiffness was also observed.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 3 - 4
Pages: 188 - 189
Publication Date: 2009/12/03
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2009.10.115 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - L. Ryliskyte
AU  - J. Badariene
AU  - V. Dzenkeviciute
AU  - A. Cypiene
AU  - V. Skorniakov
AU  - A. Laucevicius
PY  - 2009
DA  - 2009/12/03
TI  - P8.09 C-REACTIVE PROTEIN IS ASSOCIATED WITH ENDOTHELIUM-DEPENDENT ALTERATIONS OF MICROCIRCULATION IN PATIENTS WITH METABOLIC SYNDROME
JO  - Artery Research
SP  - 188
EP  - 189
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.115
DO  - 10.1016/j.artres.2009.10.115
ID  - Ryliskyte2009
ER  -

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