Artery Research

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Volume 3, Issue 4, December 2009, Pages 185 - 185

P7.10 ARTERIAL STIFFNESS IS A DETERMINANT OF INCREASED LEVELS OF AMINO TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDE – THE ROTTERDAM STUDY

Authors
J.H.W. Rutten1, F.U.S. Mattace-Raso2, G.C. Verwoert3, J. Lindemans4, A. Hofman3, J.C.M. Witteman3, A.H. van den Meiracker1
1Erasmus University Medical Centre, Department of Internal Medicine, Section of Pharmacology, Vascular and Metabolic Diseases, Rotterdam, Netherlands
2Erasmus University Medical Centre, Department of Internal Medicine, Section of Geriatric Medicine, Rotterdam, Netherlands
3Erasmus University Medical Centre, Department of Epidemiology, Rotterdam, Netherlands
4Erasmus University Medical Centre, Department of Clinical Chemistry, Rotterdam, Netherlands
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.103How to use a DOI?
Abstract

Objective: Arterial stiffness is one of the main determinants of the workload of the left ventricle. Amino-terminal pro B-type natriuretic peptide (NT-proBNP) is released by cardiomyocytes in response to left ventricular wall stress. The aim of this study was to investigate whether arterial stiffness is an independent determinant of amino-terminal pro B-type natriuretic peptide (NT-proBNP).

Methods: Cross-sectional study of a large population-based cohort free of cardiovascular disease in Rotterdam, The Netherlands (n=5,138).

Results: Mean age was 67.4±7.6 years in men and 68.7±8.2 in women. Median NT-proBNP was lower in men than women (6.7 versus 10.0 pmol/l [57 versus 86pg/ml], p<0.001). In men, measures of arterial stiffness correlated with NT-proBNP (PP, r=0.331; PWV, r=0.258; CD, r=−0.266, all p<0.001). These associations remained significant after adjustment for age, body mass index, heart rate, smoking, diabetes, renal function, total and high density lipoprotein cholesterol and use of lipid lowering and antihypertensive medication (PP, r=0.195; PWV, r=0.100; CD, r=−0.092, all p<0.001). In women, associations were weaker (PP, r=0.245; PWV, r=0.235; CD, r = − 0.232, all p<0.001), but also remained significant after multivariable adjustment (PP, r=0.083; PWV, r=0.051; CD, r = −0.066, all p<0.02).

Conclusions: Measures of arterial stiffness are independently associated with NT-proBNP serum levels in older subjects. The associations are stronger in men than in women.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
3 - 4
Pages
185 - 185
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.103How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - J.H.W. Rutten
AU  - F.U.S. Mattace-Raso
AU  - G.C. Verwoert
AU  - J. Lindemans
AU  - A. Hofman
AU  - J.C.M. Witteman
AU  - A.H. van den Meiracker
PY  - 2009
DA  - 2009/12/03
TI  - P7.10 ARTERIAL STIFFNESS IS A DETERMINANT OF INCREASED LEVELS OF AMINO TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDE – THE ROTTERDAM STUDY
JO  - Artery Research
SP  - 185
EP  - 185
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.103
DO  - 10.1016/j.artres.2009.10.103
ID  - Rutten2009
ER  -