P2.09 INCREASED CAROTID INTIMA MEDIA THICKNESS AND WAVE REFLECTION IN PATIENTS WITH INTRACRANIAL ANEURYSMS

F. Santini; C. Morizzo; C. Martini; E. Malshi; M. Caniglia; M. Kozakova; G. Parenti; C. Palombo

doi:10.1016/j.artres.2009.10.025

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Volume 3, Issue 4, December 2009, Pages 179 - 179

P2.09 INCREASED CAROTID INTIMA MEDIA THICKNESS AND WAVE REFLECTION IN PATIENTS WITH INTRACRANIAL ANEURYSMS

Authors

F. Santini¹, C. Morizzo¹, C. Martini², E. Malshi¹, M. Caniglia², M. Kozakova¹, G. Parenti², C. Palombo¹

¹University of Pisa, Department of Internal Medicine, Pisa, Italy

²University of Pisa, Department of Neurosciences, Section of Neurosurgery, Pisa, Italy

Available Online 3 December 2009.

DOI: 10.1016/j.artres.2009.10.025 How to use a DOI?
Abstract: Background: whether or not the presence of intracranial aneurysms (IAs) is associated with alterations in systemic arteries is not known.

Aim of the study was to evaluate morphology and distensibility of common carotid artery (CCA) in patients with IAs and in a control group of comparable age, gender and blood pressure (BP).

Methods: twenty-eight IAs patients (19 women, mean age 55±12.2) and 27 control subjects (15 women, mean age 50±7.7) were studied. Vascular ultrasound implemented with arterial wall tracking (Aloka Alpha 10 Tokyo, Japan) was used to investigate elastic and structural properties of CCA. Indices of arterial stiffness and wave reflection (pressure independent index ß, arterial compliance (AC) and Augmentation Index (AIx) were obtained after calibration for BP. Mean CCA diameter was derived averaging systolic and diastolic values over ten cardiac cycle, while Intima Media Thickness (IMT) was measured according to the Mannheim consensus.

Results: a significantly higher AIx was observed in patients with IAs (16.84±13.2 vs 11.1±9.6%, p<0.05), while ß didn’t differ between groups (9.08±4 vs 8.77±3.07). IAs patients showed a higher IMT than controls (0.77±0.23 vs 0.61±0.12, p<0.01) without difference in diameter (7.55±0.9 vs 7.4±0.7mm). IMT correlated directly (p<0.05) with ß (r=0.37), AC (r=0.38) and AIx (r=0.32) in IAs patients but not in controls.

Conclusions: IAs patients show an increased IMT independent of age, BP and gender, which is related to increased wave reflection and arterial stiffness. This finding suggests an underlying systemic arterial involvement in patients prone to IAs.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 3 - 4
Pages: 179 - 179
Publication Date: 2009/12/03
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2009.10.025 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - F. Santini
AU  - C. Morizzo
AU  - C. Martini
AU  - E. Malshi
AU  - M. Caniglia
AU  - M. Kozakova
AU  - G. Parenti
AU  - C. Palombo
PY  - 2009
DA  - 2009/12/03
TI  - P2.09 INCREASED CAROTID INTIMA MEDIA THICKNESS AND WAVE REFLECTION IN PATIENTS WITH INTRACRANIAL ANEURYSMS
JO  - Artery Research
SP  - 179
EP  - 179
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.025
DO  - 10.1016/j.artres.2009.10.025
ID  - Santini2009
ER  -

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