Artery Research

Volume 3, Issue 4, December 2009, Pages 157 - 157

6.1 LOW-GRADE INFLAMMATION AND ENDOTHELIAL DYSFUNCTION PRECEDE THE INCREASE IN PULSE PRESSURE IN TYPE 1 DIABETES:A 20-YEAR LONGITUDINAL STUDY

Authors
I. Ferreira1, P. Hovind2, C.G. Schalkwijk1, H.-H. Parving3, P. Rossing2, C.D.A. Stehouwer1
1Maastricht University Medical Centre, Maastricht, Netherlands
2Steno Diabetes Center, Gentofte, Denmark
3University Hospital Copenhagen, Copenhagen, Denmark
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.166How to use a DOI?
Abstract

Purpose: To investigate, longitudinally, whether increases in markers of inflammation (CRP, sICAM-1) and endothelial dysfunction (sICAM-1, sVCAM-1) are associated with and precede the increase in pulse pressure (PP) in individuals with type-1 diabetes (DM1).

Methods: Inception cohort of 277 DM1 patients (114 women; mean age at diagnosis: 27.5±13.8 yrs) who were consecutively admitted, upon diagnosis, between Sep’79–Aug’84 to an outpatient diabetic clinic (Gentofte, Denmark). Throughout a follow-up period of >20 yrs, patients’ PP, other risk factors, and CRP, sICAM-1 and sVCAM-1 were measured repeatedly (at 3–4 months intervals). Associations were analysed with generalized estimating equations (GEEs) and adjusted for sex, age at diagnosis, smoking, anti-hypertensive treatment and MAP.

Results: PP increased by 0.53 mmHg/yr, CRP by 0.033mg/L/yr, sICAM-1 by 1.8 ng/ml/yr and sVCAM-1 by 1.8 ng/ml/yr over the 20-yr longitudinal period (all p<0.001). Higher levels of ln-CRP, sICAM-1 and sVCAM-1 were all significantly associated with higher levels of PP: 0.53 mmHg (95%CI: 0.05–1.00), 1.09 mmHg (0.53–1.66) and 0.94 mmHg (0.40–1.48) per SD increase in marker, respectively. In addition, levels of sICAM-1 and sVCAM-1, but not ln-CRP, at any time point, were also associated with increases in PP occurring in the 2 yrs thereafter: 0.56 mmHg (0.18–0.94), 0.53 mmHg (0.17–0.90) and −0.01 mmHg (−0.38 −0.35) per SD increase in marker, respectively. Adjustments for other risk factors did not change these associations.

Conclusion: Life-course increases in low-grade inflammation/endothelial dysfunction are associated with and precede increases in PP, supporting the view of their involvement in the development of premature arterial stiffening in diabetes.

Open Access
This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

Journal
Artery Research
Volume-Issue
3 - 4
Pages
157 - 157
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.166How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - I. Ferreira
AU  - P. Hovind
AU  - C.G. Schalkwijk
AU  - H.-H. Parving
AU  - P. Rossing
AU  - C.D.A. Stehouwer
PY  - 2009
DA  - 2009/12/03
TI  - 6.1 LOW-GRADE INFLAMMATION AND ENDOTHELIAL DYSFUNCTION PRECEDE THE INCREASE IN PULSE PRESSURE IN TYPE 1 DIABETES:A 20-YEAR LONGITUDINAL STUDY
JO  - Artery Research
SP  - 157
EP  - 157
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.166
DO  - 10.1016/j.artres.2009.10.166
ID  - Ferreira2009
ER  -