Artery Research

Volume 3, Issue 4, December 2009, Pages 162 - 162

P1.06 THE ACCURACY OF CENTRAL SYSTOLIC BLOOD PRESSURE DETERMINED FROM THE SECOND SYSTOLIC PEAK OF THE PERIPHERAL PRESSURE WAVEFORM

Authors
S.S. Hicksona, M. Butlinb, F. Mira, J. Graggabera, J. Cheriyana, M. Yasmina, J.R. Cockcroftc, I.B. Wilkinsona, C.M. McEnierya
aUniversity of Cambridge, Cambrige, United Kingdom
bMacquarie University, Sydney, Australia
cCardiff University, Cardiff, United Kingdom
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.009How to use a DOI?
Abstract

Central blood pressure may be a better predictor of cardiovascular risk than peripheral blood pressure. The central systolic blood pressure (cSBP) can be estimated from the late systolic shoulder of the radial pulse waveform (pSBP2). We compared pSBP2 with cSBP derived by a generalized transfer function in a large cohort of subjects, across a wide age-range. We also compared pSBP2 with true central SBP (cSBPi) measured by cardiac catheterization.

Non-invasive measurements were made by applanation tonometry using the SphygmoCor device. The aortic pressure waveform was derived from the radial waveform using a validated transfer function. cSBPi measurements were carried out in 38 subjects undergoing diagnostic cardiac angiography, and the radial artery pressure waveform was recorded simultaneously using the SphygmoCor device.

Data from 1,880 subjects aged 18–85 years, yielded 10,269 individual observations. There was a strong correlation (r=0.99,P<0.001) and good agreement between pSBP2 and the derived cSBP (mean difference=1±4mmHg). However, at lower average values of cSBP and pSBP2, there was a greater difference between these two variables suggesting bias in the data. There was also a strong correlation and good agreement between cSBPi and pSBP2 (r=0.96,P<0.001,mean difference=3±4mmHg), and between the derived cSBP and cSBPi (r=0.74,P<0.001,mean difference= −3±8mmHg).

pSBP2 approximates cSBP in a large cohort, across a wide age-range, but this may be inaccurate at low systolic blood pressures. The reason for this bias has not yet been established, and further investigations are required. Until this is resolved, pSBP2 should be used with caution, particularly in individuals with lower systolic blood pressures.

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Journal
Artery Research
Volume-Issue
3 - 4
Pages
162 - 162
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.009How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - S.S. Hickson
AU  - M. Butlin
AU  - F. Mir
AU  - J. Graggaber
AU  - J. Cheriyan
AU  - M. Yasmin
AU  - J.R. Cockcroft
AU  - I.B. Wilkinson
AU  - C.M. McEniery
PY  - 2009
DA  - 2009/12/03
TI  - P1.06 THE ACCURACY OF CENTRAL SYSTOLIC BLOOD PRESSURE DETERMINED FROM THE SECOND SYSTOLIC PEAK OF THE PERIPHERAL PRESSURE WAVEFORM
JO  - Artery Research
SP  - 162
EP  - 162
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.009
DO  - 10.1016/j.artres.2009.10.009
ID  - Hickson2009
ER  -