P7.08 BIOCHEMICAL LIVER FUNCTION TESTS, ADIPOSE-TISSUE HORMONES AND CARDIOVASCULAR DISEASE TRADITIONAL AND NOVEL RISK PREDICTORS: INTIMATE RELATIONSHIPS

DOI

10.1016/j.artres.2009.10.101How to use a DOI?

Abstract

Purpose: Adipocytokines secreted by adipose tissue play an important role in the pathogenesis of atherosclerosis. Arterial stiffness represents an important novel risk factor of cardiovascular disease. We investigated the association between elevated serum alanine aminotransferase (ALT) levels, adipocytokines, arterial stiffness and the 10-year risk of coronary heart disease (CHD) in a community population sample.

Methods: The study population consisted of 105 subjects (mean age: 46.6±10.6 yrs, 63M/42F). Aortic stiffness was evaluated with carotid-femoral pulse wave velocity (PWV), and the 10-year risk of CHD was estimated using the Framingham risk score (FRS).

Results: PWV was significantly increased in subjects with elevated levels of ALT compared to those with normal values of ALT (8.44±1.59 vs 6.9±1.5m/s, p<0.05), whereas there was no relationship between aspartate aminotransferase (AST), γ-glutamyl transferase (γ-GT) and PWV. After adjustment for confounding factors, such as age, mean blood pressure, fasting glucose and body mass index, ALT levels were independently associated with PWV (adjusted R2=0.547, p<0.05). Levels of leptin (r=0.334, p<0.001), resistin (r=-0.197, p<0.05) and adiponectin (r=-0.244, p<0.05) were also correlated with PWV, but multivariable regression analysis showed that only leptin (adjusted R²=0.522, p<0.05) was an independent determinant of PWV. FRS was correlated with serum ALT (r=0.262, p=0.011) and γ-GT (r=0.350, p=0.002). There was no association between FRS and adipose-tissue hormones.

Conclusion: Elevated serum ALT and leptin levels are associated with traditional cardiovascular risk estimates and novel predictors of risk such as arterial stiffness in the community population supporting the association between abnormal liver function and cardiovascular risk.

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TY  - JOUR
AU  - K. Baou
AU  - C. Vlachopoulos
AU  - N. Ioakeimidis
AU  - I. Dima
AU  - D. Terentes-Printzios
AU  - A. Siama
AU  - C. Stefanadis
PY  - 2009
DA  - 2009/12/03
TI  - P7.08 BIOCHEMICAL LIVER FUNCTION TESTS, ADIPOSE-TISSUE HORMONES AND CARDIOVASCULAR DISEASE TRADITIONAL AND NOVEL RISK PREDICTORS: INTIMATE RELATIONSHIPS
JO  - Artery Research
SP  - 185
EP  - 185
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.101
DO  - 10.1016/j.artres.2009.10.101
ID  - Baou2009
ER  -