P8.01 PREDICTORS OF AORTIC STIFFENING IN ELDERLY SUBJECTS: RESULTS OF A NINE-YEAR FOLLOW-UP

DOI

10.1016/j.artres.2009.10.107How to use a DOI?

Abstract

Objective: To investigate predictors of increase in aortic pulse wave velocity (aPWV) in elderly subjects free from overt cardiovascular disease.

Design and Method: The present study included 90 lecture attendees (“university of 3^rd age”) who were examined at baseline and after a median follow-up of 9.5 years, including the aPWV measurement using Sphygmocor. At baseline, they were aged 66.9±5.1 years, 80.0% were women, 37.8% of subjects had arterial hypertension, 5.6% diabetes mellitus, and 82.2% hyperlipidemia. We used multiple linear regression analyses to assess predictors of change in aPWV. As independent covariates we considered: sex, age, body mass index, mean arterial pressure (MAP), heart rate, fasting glucose, total cholesterol, smoking, alcohol intake and observer.

Results: The aPWV increased from 9.4 to 10.3m/s; P=0.022. While accounting for covariates, aPWV increased significantly with three factors: a 1–standard deviation change in heart rate (8.5bpm), in MAP (12.4mm Hg) and in fasting glucose (0.93mmol/l) were associated with increased aPWV amounting to 0.76m/s (95% CI: 0.23 to 1.30; P=0.0061), 0.71m/s (95% CI: 0.20 to 1.23; P=0.0079) and 0.57m/s (95% CI: 0.08 to 1.07; P=0.024), respectively.

Conclusions: In elderly subjects without manifest cardiovascular disease, mechanical load, as demonstrated by the positive association with heart rate and MAP, plays a major role in the aortic stiffening. Among metabolic factors, glucose concentration but not lipid parameters is associated with increase in aortic stiffness, possible via glycation of connective tissue within arterial wall.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - J. Seidlerová
AU  - J. Filipovský
AU  - O. Mayer
AU  - M. Dolejšová
PY  - 2009
DA  - 2009/12/03
TI  - P8.01 PREDICTORS OF AORTIC STIFFENING IN ELDERLY SUBJECTS: RESULTS OF A NINE-YEAR FOLLOW-UP
JO  - Artery Research
SP  - 186
EP  - 186
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.107
DO  - 10.1016/j.artres.2009.10.107
ID  - Seidlerová2009
ER  -