Artery Research

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2994 articles
Conference Abstract

5.1 STRESS-INDUCED SYMPATHETIC ACTIVITY AND THE RETINAL VASCULATURE: THE SABPA PROSPECTIVE STUDY

Leoné Malan, Nicolaas Malan, Wayne Smith
Pages: 78 - 78
Objectives: Retinal vessels are part of the intracranial vasculature and analysis thereof complements behavioural and brain measures. Mental stress was related to downregulation of norepinephrine in Africans. Hence we continue by assessing prospective associations between sympathetic nervous system activity...
Conference Abstract

P121 IDENTIFYING HAEMODYNAMIC DETERMINANTS OF PULSE PRESSURE: AN INTEGRATED NUMERICAL AND PHYSIOLOGICAL APPROACH

Samuel Vennin, Ye Li, Marie Willemet, Henry Fok, Haotian Gu, Peter Charlton, Jordi Alastruey, Phil Chowienczyk
Pages: 78 - 78
Purpose: Hypertension, the single biggest killer worldwide1, arises mainly as a result of an increase in central pulse pressure (PP)2, yet haemodynamic basis of that increase is still disputed. We examined the ability of a simple “reduced” model comprising a proximal characteristic impedance linked to...
Conference Abstract

12.6 THE ROLE OF NEURONAL NITRIC OXIDE SYNTHASE IN YOUNG ADULTS

Jessica Middlemiss, Sarah Evans, Joseph Cheriyan, Lucy Yang, Ian Wilkinson, Carmel McEniery
Pages: 78 - 78
Background: Early elevation in blood pressure are characterised by a hyperkinetic circulation, with an elevated cardiac index (CI) being the dominant feature. Neuronal NOS is a key regulator of vascular tone during mental stress and is attenuated in patients with established hypertension. However, the...
Conference Abstract

5.2 DIFFERENTIAL CHARACTERISTICS BETWEEN AORTIC PRESSURE AUGMENTATION AND CAROTID FLOW AUGMENTATION: CLINICAL IMPLICATIONS FOR CEREBRAL WHITE MATTER HYPERINTENSITIES

Junichiro Hashimoto, Berend Westerhof, Sadayoshi Ito
Pages: 78 - 78
Background: Aortic stiffness and pressure wave reflection have been found to be associated with age-related cerebral microvascular disease, but the underlying mechanism remains obscure. We hypothesized that cerebral (carotid) flow augmentation potentially mediates these associations. Methods: Doppler...
Conference Abstract

P122 CALCULATING RESERVOIR PRESSURE WITH OR WITHOUT FLOW INFORMATION: SIMILARITY AND ALGORITHMIC SENSITIVITY AT RADIAL ARTERY

Michael Ebner, Kim Parker, Tom Vercauteren, Sébastien Ourselin, Siegfried Wassertheurer, Alun Hughes, Bernhard Hametner
Pages: 78 - 79
Background: Reservoir pressure is typically estimated from the pressure waveform information only. Comparability with estimates made using pressure and flow depend on assumptions, e.g. a proportional relationship between excess pressure and flow [1]. In this study, we compared (i) results using flow...
Conference Abstract

12.7 THE RELATIONSHIP BETWEEN FUNCTIONAL ARTERIAL RESPONSE AND CIRCULATING BIOMARKERS OF PATIENTS WITH FIBROMUSCULAR DYSPLASIA

Thi-Phuong-Nhung Hoang, Pierre Boutouyrie, Hakim Hettab, Louise Marais, Aurelien Lorthioir, Michael Frank, Ralph Niarra, Jean-Marie Renard, Yann Chambon, Xavier Jeunemaitre, Pierre-François Plouin, Stéphane Laurent, Chantal Boulanger, Michel Azizi
Pages: 78 - 78
Background: Fibromuscular dysplasia (FMD) is a rare idiopathic, non-atherosclerotic non-inflammatory vascular disease. This work represents the first study of the pathophysiology of FMD. We investigated the relationships between circulating biomarkers and the non-invasive vascular parameters. Methods:...
Conference Abstract

5.3 CAROTID ARTERY STIFFNESS INCREASES THE RISK OF INCIDENT DEPRESSIVE SYMPTOMS: THE PARIS PROSPECTIVE STUDY 3

Thomas van Sloten, Pierre Boutouyrie, Muriel Tafflet, Lucile Offredo, Frédérique Thomas, Catherine Guibout, Rachel Climie, Cedric Lemogne, Bruno Pannier, Stephane Laurent, Xavier Jouven, Jean-philippe Empana
Pages: 78 - 79
Background: Late-life depression is related to poor quality of life and increased risk of mortality and cardiovascular disease. Effective interventions for prevention and treatment of late-life depression need to be developed, which requires a better understanding of late-life depression risk factors....
Conference Abstract

12.8 VENTRICULAR-ARTERIAL UNCOUPLING DOES NOT DEPEND ON ARTERIAL ELASTANCE AFTER MYOCARDIAL INFARCTION

Elena Zharikova, Svetlana Villevalde, Zhanna Kobalava
Pages: 78 - 79
Objective: Ventricular remodeling may occur following myocardial infarction (MI) of the left ventricle (LV) and such remodeling has been shown to be correlated with increased patient morbidity and mortality. It is important to estimate the likelihood of remodeling from the state of the infarcted LV....
Research Article

Reproducibility of cardiac output derived by impedance cardiography during postural changes and exercise

Martin G. Schultz, Rachel E.D. Climie, Sonja B. Nikolic, Kiran D. Ahuja, James E. Sharman
Pages: 78 - 84
Background: Evaluation of cardiac output (CO) and other haemodynamic parameters may aid in understanding factors involved in arterial blood pressure (BP) changes with exercise and postural stress. Impedance cardiography offers a rapid, non-invasive means to acquire this information, however there is...
Conference Abstract

5.4 AGE-INDUCED INCREASE IN THE ENERGY TRANSMITTED TOWARDS THE CEREBRAL CIRCULATION AS A CONTRIBUTOR TO IMPAIRED BRAIN FUNCTION

Stamatia Pagoulatou, Jonathan Mynard, Vasiliki Bikia, Julio Chirinos, Nikolaos Stergiopulos, Patrick Segers
Pages: 79 - 79
Background and Aims: The increase in arterial stiffness and pressure pulsatility with age is identified as a key contributor to cognitive impairment; nevertheless, the underlying hemodynamic mechanisms remain unclear. A hypothesis, proposed by (1), suggests that the preferential stiffening of the central...
Conference Abstract

P123 RESERVOIR PRESSURE IS INDEPENDENTLY ASSOCIATED WITH 11–12 YEAR OLD’S KIDNEY FUNCTION: POPULATION-DERIVED STUDY

Xiaoqing Peng, Martin Schultz, Michael Cheung, Melissa Wake, Jonathan Mynard, David Burgner, Richard Liu, James Sharman
Pages: 79 - 79
Introduction: Reservoir pressure (RP) and excess pressure (XSP) independently predict cardiovascular events in adults, but have never been investigated as markers of cardiovascular risk among children. This study aimed to determine the association of RP and XSP with end-organ makers of cardiovascular...
Conference Abstract

12.9 VENTRICULAR ARTERIAL COUPLING IN ISOMETRIC HANDGRIP TEST IN UNTREATED HYPERTENSIVE PATIENTS

Anna Bogomaz, Yulia Kotovskaya, Zhanna Kobalava
Pages: 79 - 79
Aim: To evaluate cardiovascular adaptation to increased afterload during handgrip isometric exercise (HIE) in untreated hypertensive patients. Methods: 75 untreated hypertensive patients (age 54±7years, 44 males, BP 153/93 mmHg) underwent simultaneous EchoCG and blood pressure (BP) acquisition at rest...
Conference Abstract

5.5 MEDIATOR EFFECT OF CARDIORESPIRATORY FITNESS ON THE RELATIONSHIP BETWEEN ARTERIAL STIFFNESS AND COGNITIVE FUNCTION

Alinne Nascimento, Raquel Silva, Joana Carvalho, Lucimere Bohn
Pages: 79 - 79
Objective: The study aims to investigate the role of cardiorespiratory fitness as a mediator of the relationship between arterial stiffness and cognitive function in apparently healthy seniors. Methods: This is a cross-sectional study comprising 155 participants (75.5 ± 6.5 years; 69.7% female). Arterial...
Conference Abstract

P124 VALIDITY AND RELIABILITY OF PULSE WAVE ANALYSIS ESTIMATED BY A NOVEL WRIST-WORN TONOMETER

Luis Garcia-Ortiz, Jose Recio-Rodriguez, Cristina Agudo-Conde, Rita Salvado, Jose Maderuelo-Fernandez, Jesus Gonzalez-Sanchez, Emiliano Rodriguez- Sanches, Manuel Gómez-Marcos, on behalf EVA_Investigators
Pages: 79 - 79
Objective: To analyze the reliability and validity of Pulse Wave Analysis determined with the new wrist-worn tonometry. Methods: Cross sectional study including 254 subjects. Aged 51.9±13.4, being women 53%. Main measurements: Peripheral AIx (PAIx) and Central AIx (CAIx) by wrist-worn tonometry and...
Conference Abstract

12.10 REDUCED VENTRICULAR-ARTERIAL COUPLING AS AN EARLY MARKER OF CARDIOVASCULAR REMODELING IN HYPERTENSIVE MEN

Anna Bogomaz, Yulia Kotovskaya, Zhanna Kobalava
Pages: 79 - 79
Objective: To evaluate ventricular-arterial coupling (VAC), left ventricular hypertrophy (LVH), diastolic function and arterial stiffness in young and middle-aged men with uncomplicated arterial hypertension Methods: 97 young men aged 18–27 years (21,2±1,9 years, BP 156,5±14,0/98,5±9,1 mmHg) and 68...
Conference Abstract

P125 USE OF VASCULAR ADAPTATION IN RESPONSE TO MECHANICAL LOADING FACILITATES PERSONALISATION OF A ONE-DIMENSIONAL PULSE WAVE PROPAGATION MODEL

Maarten Heusinkveld, Koen Reesink, Theo Arts, Wouter Huberts, Tammo Delhaas
Pages: 79 - 80
Background: Mathematical modelling of pressure and flow waveforms in blood vessels using pulse wave propagation (PWP) models could support clinical decision-making. For a personalised model outcome, measurements of all modelled vessel radii and wall thicknesses are required. In clinical practice, however,...
Conference Abstract

12.11 SARCOPENIA AND VASCULAR RISK IN A HEALTHY ELDERLY UK POPULATION (BRAVES STUDY)

A. Nagy, I. Ramsay, J. Wright, C. Morrison, C. Bulpitt, F. Fantin, M. Zamboni, C. Rajkumar
Pages: 79 - 79
Introduction: Sarcopenia, the loss of skeletal muscle mass and strength that occurs with advancing age [1] is correlated with functional decline and disability but little is known about its relationship with cardiovascular risk. Bioimpedence analysis (BIA) is a validated technique for measuring muscle...
Conference Abstract

13.1 THE EFFECTS OF ALPHA 1-ADRENOCEPTOR-BLOCKADE AND ANGIOTENSIN CONVERTING ENZYME-INHIBITION ON INDICES OF AORTIC STIFFNESS MEASURED BY AN OSCILLOMETRIC SINGLE CUFF METHOD IN HYPERTENSION: THE DOXAZOSIN RAMIPRIL STUDY

Andreas Jekell, Majid Kalani, Thomas Kahan
Pages: 79 - 80
Objectives: To study whether inhibition of the renin-angiotensin-aldosterone system has effects on arterial stiffness beyond blood pressure (BP) reduction alone. Methods: Hypertensive patients (age 54±12 years, 34% women) were randomized double-blind to ramipril (10 mg od, n=32) or doxazosin (8 mg od,...
Review Article

Arterial structure and function in end-stage renal disease

Bruno Pannier, Alain P. Guérin, Sylvain J. Marchais, Fabien Métivier, Gérard M. London
Pages: 79 - 88
Cardiovascular disease (CVD) is a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). The risk of CVD disease in these patients appears to be far greater than in the general population and even after the stratification for age, gender, race and the presence or absence...
Research Article

Limitations and pitfalls of non-invasive measurement of arterial pressure wave reflections and pulse wave velocity

Patrick Segers, Jan Kips, Bram Trachet, Abigail Swillens, Sebastian Vermeersch, Dries Mahieu, Ernst Rietzschel, Marc De Buyzere, Luc Van Bortel
Pages: 79 - 88
In this paper, we briefly revise some of the most widely applied methods to non-invasively assess pressure wave reflection (augmentation index) and arterial stiffness (pulse wave velocity; PWV) in clinical vascular research. It is clear that the pressure waveform alone provides insufficient information...
Conference Abstract

P1 DETERMINANTS OF PERIPHERAL PULSE PRESSURE AND PULSE PRESSURE AMPLIFICATION

Ye Li, Antoine Guilcher, Samuel Vennin, Jordi Alastruey-arimon, Phil Chowienczyk
Pages: 80 - 80
Conference Abstract

P126 COMPARISON OF PULSE WAVE ANALYSIS ASSESSMENT METHODOLOGY IN ELDERLY MEN

Elizabeth Ellins, Kirsten Smith, Lucy Lennon, Olia Papacosta, Goya Wannamethee, Peter Whincup, Julian Halcox
Pages: 80 - 80
Background: Both the Sphygmocor (S) and Vicorder (V) devices can be used for pulse wave analysis (PWA). However, large studies comparing data from both devices are lacking. Methods: 1,722 men (78.5±4.7yrs) from the British Regional Heart Study underwent PWA with S and V devices. Brachial blood pressure...
Conference Abstract

13.2 EFFECTS ON VASCULAR STRUCTURE AND FUNCTION OF SINGLE AT1R BLOCKADE OR ITS COMBINATION WITH CCB, DIURETICS OR THEIR TRIPLE ASSOCIATION

Pedro Forcada, Carlos Castellaro, Jorge Chiabaut, Sergio Gonzalez, Carol Kotliar, Sebastian Obregon
Pages: 80 - 80
Conference Abstract

P2 DETERMINATION OF LOCAL PULSE WAVE VELOCITY DOES NOT AFFECTED BY REFLECTION

Ye Li, Ashraf Khir
Pages: 80 - 80
Objective: PWV is an important indicator of arterial stiffness and cardiovascular diseases. Local PWV would provide a more accurate estimation of local stiffness than does regional PWV. Local PWV is commonly determined by loop techniques, such as the PU-loop method and the aim of this study is to examine...
Conference Abstract

P127 FLOW DYNAMICS AND ITS RELATION TO BICUSPID AORTOPATHY ASSESSED BY 4D FLOW CMR

Lydia Dux-Santoy Hurtado, Jose F. Rodriguez-Palomares, Andrea Guala, Raquel Kale, Gisela Teixido-Tura, Filipa Valente, Giuliana Maldonado, David Garcia- Dorado, Artur Evangelista
Pages: 80 - 81
Purpose: Different altered flow dynamics may influence ascending aorta (AAo) dilation morphotypes in bicuspid aortic valve (BAV) (1). Using 4D-flow CMR, we aimed to identify flow variables related to root or ascending dilation in BAV. Methods: One-hundred and one BAV patients (no severe valvular disease,...
Conference Abstract

P3 UNDERSTANDING THE ENDOTHELIAL – SMOOTH MUSCLE – FIBROBLASTIC CELLS INTERACTIONS ON A TISSUE-ENGINEERED VASCULAR GRAFT

Tatiana Felizardo, Nuno M. Neves, Albino Martins, Rui L. Reis
Pages: 80 - 81
There is still a pressing need to develop small-diameter vascular vessels for vascular reconstructive procedures. Tissue Engineering offers the prospect of being able to meet this medical demand, as it allows the development of structurally complex blood vessels substitutes 1. Accordingly, the ultimate...
Research Article

Lifestyle modification-induced increase in serum testosterone and SHBG decreases arterial stiffness in overweight and obese men

Hiroshi Kumagai, Asako Miyaki, Ryota Higashino, Nobuhiko Akazawa, Youngju Choi, Song-Gyu Ra, Miki Eto, Kiyoji Tanaka, Ryuichi Ajisaka, Seiji Maeda
Pages: 80 - 87
Background: Arterial stiffness—a risk factor for cardiovascular diseases—is more frequently observed in obese men. Moreover, the male sex hormone testosterone has an anti-atherogenic effect. Serum testosterone levels are found to be lower in obese men than in age-matched normal-weight men. However, the...
Conference Abstract

P128 COMPARISON OF AUGMENTATION INDEX OBTAINED FROM HEM-9000AI AND MOBIL-O-GRAPH IN JAPANESE NORMOTENSIVE INDIVIDUALS

Masakazu Obayashi, Michihiro Kohno, Shigeki Kobayashi, Michiaki Kohno, Masafumi Yano
Pages: 81 - 81
Background: HEM-9000AI (HEM) is an established device for measurement of radial augmentation index (rAIx) used by applanation tonometry in Japan. Mobil-O-Graph (MOG) is a cuff-based oscillometric device for assessment of central aortic AIx (cAIx) and the usefulness to Europeans has been reported. We...
Conference Abstract

P5 REGIONAL VARIATIONS IN THE MICROMECHANICAL AND BIOCHEMICAL PROPERTIES OF THE OVINE AORTA

Phakakorn Panpho, Riaz Akhtar, Jill Madine, Mark Field
Pages: 81 - 81
Background: It is important to understand regional variations in the mechanical and biochemical properties of the aorta to better predict and treat diseases. Although previous studies have been explored regional differences in the structure and biomechanical properties of the aorta, little is known about...
Conference Abstract

P129 SHORT-TERM REPEATABILITY OF NON-INVASIVE AORTIC PULSE WAVE VELOCITY MEASURES

Andrea Grillo, Paolo Salvi, Sandrine Millasseau, Matteo Rovina, Corrado Baldi, Francesco Moretti, Lucia Salvi, Andrea Faini, Renzo Carretta, Filippo Scalise, Gianfranco Parati
Pages: 81 - 82
Objective: To compare the short-term repeatability of aortic pulse wave velocity (PWV) measures obtained with non-invasive devices. Methods: In 102 patients planned to undertake a cardiac catheterization (65±13 years, 70.6% males) duplicate non-invasive measures of PWV, 15-minutes apart, were obtained...
Conference Abstract

P6 ARTERIAL STRUCTURE AND COAGULATION IN AGEING NAKED MOLE RATS

Takouhie Mgrditchian-Griffo
Pages: 81 - 81
Vascular stiffening and a prothrombotic state consistently increase with age. Naked mole rats (NMRs) among rodent species have a maximum lifespan exceeding 30 years. Arterial stiffness assessed by pulse wave velocity and arterial pressure have been shown not to increase with age in NMRs (Grimes et al....
Conference Abstract

13.7 RENAL DENERVATION IN TREATMENT RESISTANT HYPERTENSION: EFFECTS ON CORONARY FLOW RESERVE AND FOREARM DILATION CAPACITY. A RANDOMIZED, DOUBLE-BLINDED, SHAM-CONTROLLED CLINICAL TRIAL

Morten Engholm, Jannik B. Bertelsen, Ole N. Mathiassen, Henrik Vase, Jesper N. Bech, Anne P. Schroeder, Ole Lederballe, Hans Rickers, Christian D. Peters, Ulla Kampmannf, Per L. Poulsen, Sten Langfeldt, Gratien Andersen, Klavs W. Hansen, Erling B. Pedersen, Jens F. Lassen, Hans E. Boetker, Niels H. Buus, Anne Kaltoft, Kent L. Christensen
Pages: 81 - 81
Conference Abstract

P7 TELOMERE LENGTH AND AORTIC VALVE CALCIFICATION

Ilona Saraieva, Simon Toupance, Magnus Back, Benetos Athanase
Pages: 81 - 82
Background: Short telomere length (TL) is associated with atherosclerosis development. Aortic valve stenosis, an age-related disease characterized by narrowing of the aortic opening, is mainly caused by aortic valve calcification. Development of aortic calcifications shares many similarities with atherogenesis,...
Conference Abstract

13.8 VENTRICULO-VASCULAR INTERACTIONS AND THE ARTERIAL WINDKESSEL: NEW INSIGHTS FROM CARDIOVASCULAR MAGNETIC RESONANCE IMAGING BEFORE AND AFTER RENAL DENERVATION

Giovanni Biglino, Amy Burchell, Jonathan Rodrigues, Robert D.M. Gray, Emma C. Hart, Julian F.R. Paton, Nathan E. Manghat, Andreas Baumbach, Angus K. Nightingale
Pages: 81 - 82
Discussion

Application of arterial hemodynamics to clinical practice: A testament to medical science in London

Michael F. O’Rourke, Audrey Adji, Wilmer W. Nichols, Charalambos Vlachopoulos, Elazer R. Edelman
Pages: 81 - 86
A strong heritage of science has been handed down in Britain from outstanding individuals, promoted and encouraged by strong scientific and medical societies. Application to clinical practice in recent years has been slow but can be expected to advance in the present and future age of new sensors, fast...
Letter to Editor

HIV and atherosclerosis: Heterogeneity of studies results

Cristina Giannattasio, Alessandro Maloberti, Andrea Gori
Pages: 81 - 83
Review Article

Atherosclerotic vascular disorders in HIV infected patients

John Palios, Ignatios Ikonomidis, John Lekakis, Maria Anastasiou-Nana
Pages: 81 - 90
Individuals infected with human immunodeficiency virus (HIV) frequently demonstrate a metabolic syndrome associated with atherosclerosis and cardiovascular disease. Extensive functional and structural arterial wall changes have been observed in these individuals. It is documented that these vascular...
Mini Review

Hypertension: Protective Effects of Physical Exercise on Cognition Function, Arterial Function and Brain Health

Marinei Lopes Pedralli, Eduardo Barbosa, Pedro Guimarães Cunha
Pages: 81 - 86
Systemic Arterial Hypertension (SAH) is a chronic condition that requires clinical treatment and is associated with increased risk of cognitive impairment and dementia. Therefore, strategies with fewer side effects and less invasive procedures are required. Evidence supports that Physical Exercise (PE)...
Research Article

Role of aortic calcification, stiffness and wave reflections in cardiovascular risk in dialysis patients: Baseline data from the CORD study

Francis Verbeke, Raymond Vanholder, Pieter L. Rensma, Björn Wikström, Per Bruno Jensen, Jean-Marie Krzesinski, Merete Rasmussen, Wim Van Biesen, Eero Honkanen, on behalf of the CORD Study investigators
Pages: 81 - 90
Background: Accurate cardiovascular risk estimation in dialysis patients remains challenging because different pathogenetic mechanisms act simultaneously in this heterogeneous population. Radiographic calcification, aortic stiffness and wave reflection, have each individually been proven to be reliable...
Conference Abstract

P4 MECHANISM OF PROANGIOGENIC ACTIVITY OF MITOCORRECTIN ON ENDOTHELIAL CELLS IN VITRO

Tetiana Nikolaienko, Victoriia Nikulina, Liudmyla Garmanchuk, Oleksander Makarenko
Pages: 81 - 81
Background: Investigations of different effective treatment modalities of infectious and inflammatory complications of stroke remain relevant. Normalization of vascularization, impaired due to hypoxia, is an important component of ischemic disease treating. The aim of our work was to study the mechanism...
Conference Abstract

P8 THE EFFECT OF CAFFEINE ON MENTAL STRESS RELATED CARDIOVASCULAR RESPONSE

Ziva Melik, Ksenija Cankar
Pages: 82 - 82
Background: Caffeine, the most widely used pharmacologically active substance causes mental stimulation and a slight raising of blood pressure. The aim of our work was to evaluate the effect of caffeine on the cardiovascular system during rest and during mental stress. Methods: RR interval duration,...
Conference Abstract

P130 TEST-RETEST RELIABILITY FOR PULSE WAVE VELOCITY AND CARDIO-ANKLE VASCULAR INDEX AMONG AFRO-CARIBBEAN YOUNG ADULTS

Janeil M. Williams, Trevor S. Ferguson, Nadia R. Bennett, Amanda Rousseau, Renee Walters, Novie O. Younger-Coleman, Marshall K. Tulloch-Reid, Seeromanie Harding, J. Kennedy Cruickshank, Rainford J. Wilks
Pages: 82 - 82
Background: This study evaluated the test-retest reliability of carotid-femoral pulse wave velocity (PWV) and cardio-ankle vascular index (CAVI) among young adults in Jamaica. Methods: We recruited participants from the Jamaica 1986 Birth Cohort Study. PWV was measured using the Arteriograph device™...
Conference Abstract

P10 COMBINATION OF FLOW-MEDIATED DILATION AND PULSE WAVE VELOCITY PROVIDES FURTHER CARDIOVASCULAR RISK STRATIFICATION IN PATIENTS WITH CORONARY ARTERY DISEASE: FLOW-MEDIATED DILATION JAPAN STUDY A (FMD-J A)

Yukihito Higashi, Tatsuya Maruhashi, Hirofumi Tomiyama, Bonpei Takase, Toru Suzuki, Yasuki Kihara, Akira Yamashina
Pages: 82 - 82
Purpose/Background/Objective: The usefulness of vascular function tests for management of patients with coronary artery disease (CAD) has not been fully investigated. Methods: We measured flow-mediated vasodilation (FMD) and brachial-ankle pulse wave velocity (baPWV) in 462 patients with CAD for assessment...
Conference Abstract

P131 DETERMINANTS OF A NEW, NON-INVASIVE INDEX OF VENTRICULAR-ARTERIAL COUPLING AND MYOCARDIAL PERFORMANCE IN A GENERAL POPULATION SAMPLE

Nicholas Cauwenberghs, Jan D’hooge, Lutgarde Thijs, Jan A. Staessen, Tatiana Kuznetsova
Pages: 82 - 82
Background: The interaction between the heart and arteries (i.e. ventricular-arterial coupling, VAC) is a key determinant of cardiovascular performance. As such, VAC indexes might reflect the interplay between arterial stiffness and left ventricular (LV) dysfunction. In a community-based sample, we assessed...
Conference Abstract

P11 EFFECT OF AGING ON THE PRESSURE ASYMPTOTE AND TIME CONSTANT OF EXPONENTIAL DIASTOLIC AORTIC PRESSURE DECAY IN HUMANS

Tetsu Yamakado
Pages: 82 - 82
There are few data regarding the effect of aging on pressure asymptote (Pasymptote) and time constant (Tau) of exponential diastolic aortic pressure (AoP) decay in normal human heart. To investigate this issue, we analyzed high-fidelity AoP, measured by use of a catheter-tipped manometer in 71 normal...
Conference Abstract

P165 HIGHER BLOOD PRESSURE IN YOUTH IS ATTRIBUTABLE TO A COMBINATION OF HIGHER CARDIAC OUTPUT AND HIGHER TOTAL PERIPHERAL RESISTANCE

Alun Hughes, Chloe Park, Abigail Fraser, Laura Howe, Siana Jones, Debbie Lawlor, NIsh Chaturvedi, George Davey Smith
Pages: 82 - 83
Background: It has been proposed that high blood pressure (BP) in young people is due to high cardiac output (CO) with normal total peripheral resistance (TPR) – a hyperkinetic/hyperdynamic circulation. We investigated this in a large, population- based cohort of adolescents. Methods: The study was...
Conference Abstract

13.11 EFFECTS OF DAPAGLIFLOZIN ON EARLY ALTERATIONS OF THE MICRO- AND MACROCIRCULATION

Christian Ott, Iris Kistner, Agnes Jumar, Stephanie Friedrich, Peter Bramlage, Roland Schmieder
Pages: 82 - 82
Conference Abstract

P12 VALIDATION OF SYNTHESIZED CENTRAL PRESSURE WAVEFORM IN PATIENTS WITH AN INFRARENAL AORTIC ANEURYSM BEFORE AND AFTER ENDOVASCULAR REPAIR

Suzanne Holewijn, Lennart van der Velde, Majorie van Helvert, Thomas Urgert, Gerike Buitenhuis, Erik Groot Jebbink, Michel Reijnen
Pages: 82 - 83
Background: Abdominal aortic aneurysm (AAA) disease is mainly treated by endovascular aneurysm repair (EVAR), which shows short-term advantages in terms of lower morbidity and mortality compared to open repair. Long-term outcome seems te be inferior with regard to survival. This could partly be explained...
Research Article

Differential Sensitivity of Brachial-Ankle Pulse Wave Velocity and Ankle-Brachial Index for Cardiovascular Risk Assessment in Elderly Chinese: A Cross-Sectional Study

Guoxiang Fu, Yuan Zhong, Fengfeng Pan, Chanchan Xu
Pages: 82 - 86
Background: Brachial-Ankle Pulse Wave Velocity (baPWV) and Ankle-Brachial Index (ABI) are widely used in clinic for evaluating arterial stiffness and atherosclerosis separately. This study aimed to compare the sensitivity of baPWV and ABI for cardiovascular risk assessment in elderly Chinese. Methods:...
Conference Abstract

P13 VASCULAR AND MUSCLE DETERIORATION IN OLDER OUTPATIENTS

Lisanne Tap, Linda Kannegieter, Antine Flikweert, Francesco Mattace Raso
Pages: 83 - 83
Background: Vascular and muscle deterioration are age-related processes, which both have a major impact on health and might share common predisposing factors and mechanisms. We investigated the possible association between aortic stiffness and physical performance in older outpatients. Methods: Aortic...
Conference Abstract

P166 HEAD-DOWN TILT BED-REST SIGNIFICANTLY INCREASES CENTRAL ARTERIAL STIFFNESS

Fouassier David, Hakim Khettab, Pierre Boutouyrie, Carole Leguy, Catalin Cristian
Pages: 83 - 83
The vascular system is subject to continual variation in mechanical stresses, both physiological and pathological. Vascular remodeling via changes in vessel wall properties, including thickness and stiffness, is a major feature of aging and cardiovascular disease. A more detailed understanding of the...
Conference Abstract

P14 REFERENCE VALUES OF THE WEST SPANISH POPULATION OF THE HEMODYNAMIC INDICES EVALUATED WITH A NEW WRIST WORN DEVICE

Marta Gomez-Sanchez, Leticia Gomez-Sanchez, Rosario Alonso-Domínguez, Jesus Gonzalez-Sanchez, Cristina Agudo- Conde, Natalia Sánchez-Aguadero, Carmela Rodriguez-Martin, Luis Garcia-Ortiz
Pages: 83 - 84
Objective: To describe the reference value of arterial stiffness parameter measurement by wrist worn device (Microsoft) in west Spanish population. Methods: Cross-sectional study. Study population: From the population assigned to the participating healthcare centres, a cluster random sampling stratified...
Conference Abstract

P167 PULSE PRESSURE AMPLIFICATION AND AUGMENTATION INDEX CHANGE IN OPPOSITE MANNER WITH ARTERIAL STIFFNESS INDEPENDENTLY OF SYSTEMIC RESISTANCE

Nicolaas Westerhof, Berend Westerhof
Pages: 83 - 83
Background: Pulse Pressure Amplification (PPA) is the increase in Pulse Pressure (PP) from proximal to distal arteries. The Augmentation Index (AIx) is the secondary increase in aortic pressure in systole relative to PP. With aging and increased arterial stiffness the PPA decreases while the AIx increases....
Conference Abstract

P168 ENDOTHELIAL REGULATION OF AWV IS IMPAIRED DURING INCREASE IN BLOOD FLOW IN ESSENTIAL HYPERTENSION

Frederic Roca, Jeremy Bellien, Michele Iacob, Robinson Joannides
Pages: 83 - 84
Background: Arterial wall viscosity (AWV) depends on endothelium-derived factors in physiological conditions (1,2). Hypertension is characterized by an altered FMD during sustained flow increase due to endothelial dysfunction (3). Whether NO and EETs regulate change in AWV during increase in flow in...
Conference Abstract

14.5 LEVELS OF ANGIOPOIETIN-LIKE-2 ARE POSITIVELY ASSOCIATED WITH AORTIC STIFFNESS AND MORTALITY AFTER KIDNEY TRANSPLANTATION

Marie-Pier Desjardins, Nathalie Thorin-Trescases, Aboubacar Sidibe, Sacha De Serres, Richard Larivière, Eric Thorin, Mohsen Agharazii
Pages: 83 - 84
Review Article

Transcranial Doppler evaluation of cerebral hemodynamic alteration in preterms with early onset neonatal sepsis

Rania H. Hashem, Yasmin E. Abdalla, Yasmen A. Mansi, Mohamed H. Shaaban, Hassan A. El Kiki
Pages: 83 - 90
Objective: To evaluate the cerebral blood flow and the cerebral hemodynamic alteration by Doppler ultrasound in preterms with early onset-neonatal sepsis. Method: Total forty two preterms divided into two groups whether with clinical and laboratory diagnosis of early onset neonatal sepsis (EONS) or...
Conference Abstract

P15 EFFECT OF UPRIGHT POSTURE ON CENTRAL WAVE REFLECTION IN 637 VOLUNTEERS NOT USING MEDICATIONS WITH DIRECT CARDIOVASCULAR INFLUENCES: DESCRIPTION OF DIFFERENT PHENOTYPES

Ilkka Pörsti, Matias Wilenius, Antti Tikkakoski, Arttu Eräranta, Manoj Kumar Choudhary, Jenni Koskela, Anna Tahvanainen, Jukka Mustonen
Pages: 84 - 84
Background: The effect of upright posture on the level of augmentation index (AIx) remains controversial [1–3]. Phenotypic differences in AIx responses to upright posture are unknown. Methods: Altogether 323 women and 315 men without cardiovascular disease and medications with direct cardiovascular...
Conference Abstract

P170 SHORT-TERM EFFECTS OF TRANSCATHETER AORTIC VALVE IMPLANTATION ON AORTIC FUNCTION AND HEMODYNAMICS

Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Konstantinos Toutouzas, Georgios Latsios, Andreas Synetos, Georgios Trantalis, Fani Mitropoulou, Maria Drakopoulou, Konstantinos Stathogiannis, Vicky Penesopoulou, Konstantinos Kalogeras, Konstantinos Aznaouridis, Manolis Vavuranakis, Dimitrios Tousoulis
Pages: 84 - 84
Purpose/Background/Objectives: Aortic stiffness and hemodynamics are independent predictors of adverse cardiovascular events. Transcatheter aortic valve implantation (TAVI) is growingly used in elderly patients with aortic stenosis. We sought to investigate the effect of TAVI upon aortic vascular function...
Conference Abstract

P16 PULSE WAVE VELOCITY AND ITS ASSOCIATION WITH FIRST CARDIOVASCULAR EVENTS IN A PORTUGUESE HYPERTENSIVE SAMPLE

Clarinda Neves, Joana Ricardo Pires, Verónica Ribau, José Mesquita Bastos
Pages: 84 - 84
Objective: Pulse Wave Velocity (PWV) is considered a marker of cardiovascular (CV) risk prognosis. The objective was to evaluate the association of PWV, other features and CV events in a sample of hypertensive patients. Design and method: We studied 314 hypertensive patients without previous CV events...
Conference Abstract

P171 COMPLIANCE OF EXTREMELY DILATED MAIN PULMONARY ARTERIES IN PULMONARY ARTERIAL HYPERTENSION

Joanne Groeneveldt, Tijmen van der Wel, Tim Marcus, Frances De Man, Anton Vonk Noordegraaf, Nicolaas Westerhof, Berend Westerhof
Pages: 84 - 85
Background: Main pulmonary artery (MPA) dilation is a radiological sign of pulmonary hypertension (PH) and is an independent risk factor of sudden death (Żyłkowska et al, Chest 2012). Extreme MPA dilation is a rare consequence of PH. We hypothesize that the main pulmonary artery compliance is larger...
Conference Abstract

14.7 HYALURONAN IS ASSOCIATED WITH AORTIC STIFFENING IN HEALTHY SUBJECTS

Kaisa Maki-Petaja, Kimberley Chan, Carmel McEniery, Ian Wilkinson
Pages: 84 - 84
Conference Abstract

P17 ARTERIAL STIFFNESS OF THE FOREARM IS ASSOCIATED WITH NAILFOLD CAPILLARY COUNT IN SYSTEMIC SCLEROSIS: A NOVEL MARKER OF EARLY VASCULOPATHY?

Anniek van Roon, Amaal Eman Abdulle, Arie van Roon, Saskia van de Zande, Hendrika Bootsma, Andries Smit, Udo Mulder
Pages: 84 - 85
Background: Microvascular disease, with rarefaction of nailfold capillaries, is the hallmark of systemic sclerosis (SSc). Obliteration of the ulnar and radial artery is regularly observed, implicating involvement of the forearm arteries. Pulse wave velocity (PWV) may serve as early biomarker of forearm...
Conference Abstract

14.8 VASCULAR ABNORMALITIES RELATED WITH OBESITY

Pedro Forcada, Carlos Castellaro, Jorge Chiabaut, Sergio Gonzalez, Carol Kotliar, Sebastian Obregon
Pages: 84 - 84
Research Article

Spatial and temporal characteristics of Ca2+ signaling in endothelial cells of intact rat tail artery

Sadaf Mumtaz
Pages: 84 - 92
Very few studies have described briefly the spatial and temporal characteristics of Ca2+ signaling using ATP, bradykinin, histamine and thrombin in cultured endothelium. However so far, the spatial and temporal characteristics in intact endothelium have not been elucidated. The aim of this work was...
Research Article

Myocardial Bridge Anatomical Characteristics Relationship with ECG Changes and Markers

Hussein Nafakhi, Abdulameer A. Al-Mosawi, Samet Kasim
Pages: 84 - 88
Background: The clinical significance of coronary Myocardial Bridge (MB) anatomical characteristics is controversial in the literature. It is not clear whether MB has a benign or malignant clinical outcome. Objectives: To investigate the possible relationship between MB characteristics (depth, length...
Conference Abstract

NON-INVASIVE ASSESSMENT OF MECHANICAL PROPRERTIES AND COMPOSITION OF VULNERABLE CAROTID PLAQUES

Anna Paini, Pierre Boutouyrie, Massimo Salvetti, David Calvet, Maria Lorenza Muiesan, Enrico Agabiti-Rosei, Stéphane Laurent
Pages: 85 - 85
Conference Abstract

P172 VOLUNTARY LIQUORICE INGESTION INCREASES BLOOD PRESSURE VIA MULTIPLE MECHANISMS: INCREASED VOLUME LOAD, PERIPHERAL ARTERIAL RESISTANCE, AND DECREASED AORTIC COMPLIANCE

Elina J. Hautaniemi, Anna M. Tahvanainen, Jenni K. Koskela, Antti J. Tikkakoski, Mika Kähönen, Marko Uitto, Kalle Sipilä, Onni Niemelä, Jukka Mustonen, Ilkka H. Pörsti
Pages: 85 - 85
Objectives: Liquorice consumption elevates blood pressure [1–3], but the liquorice-induced haemodynamic changes in the upright position are unknown. We investigated haemodynamics after liquorice exposure in healthy volunteers during orthostatic challenge. Methods: Haemodynamics were recorded from 22...
Conference Abstract

14.10 INCREASED CENTRAL PRESSURE AUGMENTATION IS ASSOCIATED WITH REDUCED SLEEP DURATION IN INDIVIDUALS EXPOSED TO AIRCRAFT NOISE POLLUTION: THE SERA-CV STUDY

Rosa Maria Bruno, Ugo Faraguna, Enrica Bonanni, Marina Di Pilla, Marco Di Galante, Tommaso Banfi, Angelo Gemignani, Gaetano Licitra, Francesco Fidecaro, Stefano Berrettini, Maria Angela Vigotti, Stefano Taddei, Lorenzo Ghiadoni
Pages: 85 - 85
Conference Abstract

P19 EFFECT OF GROWTH HORMONE REPLACEMENT IN THE VASCULAR SYSTEM OF ADULT PATIENTS WITH CHILDHOOD ONSET HYPOPITUITARISM

Isabela Biscotto, Valeria Costa-Hong, Luiz Bortolotto, Luciani Carvalho
Pages: 85 - 85
Objective: To evaluate the human recombinant growth hormone replacement (hrGHr) in the metabolic parameters and vascular system in adult patients with childhood onset hypopituitarism (COH). Patients and methods: Fifty-one adult with COH were selected for the study. They were divided into 2 groups: 1-...
Conference Abstract

P173 COUPLED NITROSO-SULFIDE SIGNALIZATION TRIGGERS SPECIFIC VASOACTIVE EFFECTS IN INTRARENAL ARTERIES OF PATIENTS WITH ARTERIAL HYPERTENSION

Sona Cacanyiova, Andrea Berenyiova, Frantisek Kristek, Marian Grman, Karol Ondrias, Jan Breza, Jan Breza
Pages: 85 - 85
In normotensive conditions, it has been confirmed that S-nitrosothiols, as a source of NO, interact with hydrogen sulfide (H2S) and create new substance/s with specific vasoactive effects. This interaction could represent new regulator pathway also in hypertension. The aim of the study was to investigate...
Conference Abstract

14.11 TOTAL ARTERIAL COMPLIANCE AS A RISK FACTOR FOR ORGAN DAMAGE IN HYPERTENSION

Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Panagiota Pietri, Panagiotis Xaplanteris, Eleftherios Paschalidis, Nikitas Skliros, Dimitrios Tousoulis
Pages: 85 - 86
Conference Abstract

P20 BRACHIAL AND RADIAL SYSTOLIC BLOOD PRESSURE ARE NOT THE SAME: POTENTIAL IMPLICATIONS FOR VALIDATION PROTOCOLS INCLUDING BRACHIAL CUFF DEVICES AND WRIST-BASED WEARABLES

Matthew Armstrong, Martin Schultz, Dean Picone, James Sharman, Nathan Dwyer, Philip Roberts-Thomson, Andrew Black
Pages: 85 - 85
Introduction: Radial intra-arterial blood pressure (BP) is sometimes used as the reference standard for validation of brachial cuff BP devices, and there is an emerging ‘wearables’ market seeking to measure BP at the wrist. However, brachial systolic BP may not be a good representation of the radial...
Conference Abstract

P174 HEMODYNAMIC AND AUTONOMIC EFFECTS OF LOW-DOSE GLYCERYL TRINITRATE USED TO TEST ENDOTHELIUM-INDEPENDENT VASODILATION OF THE BRACHIAL ARTERY

Lorenzo Ghiadoni, Stefano Taddei, Rosa Maria Bruno
Pages: 85 - 85
Background/Aim: Smooth muscle function is explored by sublingual glyceryl trinitrate (GTN) administration in vascular function protocols, in order to compare with endothelium- dependent vasodilation of the brachial artery by flow-mediated dilation (FMD). The aim of this study is to evaluate the hemodynamic...
Conference Abstract

15.1 ANALYSIS OF THREE STATISTICAL METHODS TO PREDICT THE PRESENCE OF CAROTID ATHEROMATOUS PLAQUES

Daniel Schang, Mathieu Feuilloy, Magid Hallab, Mathieu Collette, Georges Leftheriotis
Pages: 85 - 86
Background: At least 15–20% of all ischemic strokes are attributable to atherosclerosis [1]. We analyzed three statistical methods for 12 traditional risk factors (TRF) i.e. age, sex, arterial pressure, Intima Media Tickness (IMT), Pulse Wave Velocity (PWV) in order to predict the presence of carotid...
Conference Abstract

P21 CHARACTERIZATION OF AN ATHEROSCLEROTIC PHENOTYPE

Pedro Forcada, Castellaro Carlos, Sergio Gonzalez, Carol Kotliar, Sebastian Obregon, Jorge Chiabaut Svane
Pages: 85 - 86
Background: Interaction between gentics and epigenetics has been largely described in Atherosclerotic Disease and the relations varies widely according to the population, clinical characteristics and the study type. Objective: Compare genetic and epigenetic factors in two middle age populations with...
Conference Abstract

P175 AN ACUTE BOUT OF PROLONGED SITTING IMPAIRS ENDOTHELIAL FUNCTION AND INCREASES PLASMA CONCENTRATIONS OF ENDOTHELIN-1 IN OVERWEIGHT/OBESE ADULTS: IMPLICATIONS FOR GLUCOSE AND INSULIN METABOLISM

Megan Grace, Rachel Climie, Michael Wheeler, Nina Eikelis, Joshua Carr, Francis Dillon, Neville Owen, Danny Green, Bronwyn Kingwell, David Dunstan
Pages: 85 - 86
Background: Compared to regular active breaks, prolonged uninterrupted sitting amplifies postprandial glucose and insulin in overweight/obese adults with and without type 2 diabetes; and impairs lower limb endothelial function (a predictor of cardiovascular disease) in healthy adults. However, the effects...
Research Article

The addition of whole-body vibration to a lifestyle modification on arterial stiffness in overweight and obese women

Asako Miyaki, Seiji Maeda, Youngju Choi, Nobuhiko Akazawa, Yoko Tanabe, Rina So, Kiyoji Tanaka, Ryuichi Ajisaka
Pages: 85 - 91
Background: Increased arterial stiffness is an independent risk factor for cardiovascular disease. Arterial stiffness increases in obese individuals as compared to normal weight. While weight loss by calorie-restriction alone decreases arterial stiffness in obesity, it decreases muscle mass. Resistance...
Conference Abstract

P18 AORTIC STIFFNESS IN AORTIC STENOSIS: SHORT TERM HEMODYNAMIC CHANGES AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION

Jeannette Goudzwaard, Nahid El Faquir, Nicolas van Mieghem, Marjo de Ronde-Tillmans, Mattie Lenzen, Peter de Jaegere, Francesco Mattace-Raso
Pages: 85 - 85
Background: Both aortic valve stenosis as aortic stiffness are moderators of arterio-ventricular coupling and independent predictors of cardiovascular morbidity and mortality. Studies on the effect of Transcatheter Aortic Valve Implantation (TAVI) on hemodynamic parameters are limited. We performed a...
Conference Abstract

P22 THE ROLE OF RENAL DYSFUNCTION ON TARGET ORGAN DAMAGE AND CARDIOVASCULAR RISK IN HYPERTENSIVES

Eirini Solomou, Dimitrios Terentes Printzios, Charalampos Vlachopoulos, N. Ioakimidis, K. Aznaouridis, I. Koutagiar, V. Gardikioti, E. Sigala, D. Tousoulis
Pages: 86 - 86
Purpose/Background/Objective: Hypertension is associated with increased left ventricular (LV) hypertrophy, aortic stiffness and renal dysfunction, which are all predictors of cardiovascular risk. We investigated the effect of renal dysfunction on LV mass and aortic stiffness in hypertensives. Methods:...
Conference Abstract

P176 ARTERIAL STIFFNESS AS A PART OF A GENERAL ABNORMALITY OF THE FIBROUS HEALING PROCESS

Pedro Forcada, Miguel Sangiovanni, Alejandra Camino, Wanda Pampinella, Oscar Montaña
Pages: 86 - 86
Environment There seems to be a common abnormality of the healing process in several diseases as COPD, liver esteatosis, and arterial stiffening. Objective: To asses the association of frequency between liver esteatosis and aortic stiffness by means of c-f PWV in patients included in a CV prevention...
Conference Abstract

15.2 ESTIMATES OF ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE IN PATIENTS WITH TYPE 2 DIABETES: A COMPARISON OF SPHYGMOCOR AND ARTERIOGRAPH

Christoffer Krogager, Niklas B. Rossen, Klavs W. Hansen, Søren T. Knudsen, Christian D. Peters, Hans Erik Bøtker, Per L. Poulsen, Esben Laugesen
Pages: 86 - 86
Conference Abstract

01.02 GEOMETRIC AND ELASTIC PROPERTIES OF THE COMMON CAROTID ARTERY IN VASCULAR EHLERS-DANLOS SYNDROME PATIENTS WITH IDENTIFIED COL3A1 MUTATIONS

K.T. Ong, S. Laurent, J. Perdu, H. Plauchu, D. Germain, P. Collignon, G. Georgesco, E. Bozec, B. Laloux, J. De Backer, X. Jeunemaitre, P. Boutouyrie
Pages: 86 - 86
Conference Abstract

P23 THE COMPARISON OF PROGNOSTIC VALUE AMONG ANKLE BRACHIAL PRESSURE INDEX, ARTERIAL STIFFNESS AND PRESSURE WAVE REFLECTION IN SUBJECTS WITH CORONARY ARTERY DISEASE

Kazutaka Kimura
Pages: 86 - 86
Objectives: The present retrospective study was conducted to compare the prognostic value among ankle brachial pressure index (ABI), brachial-ankle pulse wave velocity (baPWV,) and radial augmentation index (rAI) in patients with coronary artery disease (CAD). Methods: ABI, baPWV and rAI were measured...