Artery Research

Volume 24, Issue C, December 2018, Pages 85 - 85

P19 EFFECT OF GROWTH HORMONE REPLACEMENT IN THE VASCULAR SYSTEM OF ADULT PATIENTS WITH CHILDHOOD ONSET HYPOPITUITARISM

Authors
Isabela Biscotto1, Valeria Costa-Hong2, Luiz Bortolotto2, Luciani Carvalho3
1Hospital das Clínicas da Faculdade de Medicina da Universidade Sao Paulo, Brasil
2Instituto do coração, Hospital das Clinicas da Faculdade de Medicina da Universidade Sao Paulo, Brasil
3Hospital das Clínicas, da Faculdade de Medicina da Universidade São Paulo, Brasil
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.072How to use a DOI?
Abstract

Objective: To evaluate the human recombinant growth hormone replacement (hrGHr) in the metabolic parameters and vascular system in adult patients with childhood onset hypopituitarism (COH).

Patients and methods: Fifty-one adult with COH were selected for the study. They were divided into 2 groups: 1- hrGHr: 13 male, 14 female with median age 33.2 yrs, rhGHr in adult life with 7.38 yrs median time; 2 - Without hrGHr: 13 male, 11 female with 36.9 yrs median age and without hrGHr in adult life of 10.4 yrs median time. Anthropometric parameters, dual-energy X-ray absorptiometry (DEXA), lipid and glycemic profile, and structural and functional parameters of the arterial vessels (carotid intima media thickness, arterial stiffness and flow mediated dilation) were evaluated.

Results: The diagnosis of obesity and overweight was higher in patients without hrGHr. Among the anthropometric characteristics, the waist-to-height ratio and diastolic blood pressure were higher in patients without replacement (p = 0.03 and p = 0.019, respectively). In the evaluation of body composition through DEXA, the Fat Mass Index among patients under hrGHr was significantly lower than in patients without hrGHr (p = 0.029). Although no statistical difference in the vascular parameters between patients with and without hrGHr, it was observed a trend towards a higher arterial stiffness in the group without replacement (p = 0.051). In the group of patients without hrGHr, arterial stiffness had a significant and positive correlation with the time without hrGHr (p = 0.038).

Conclusions: These data suggest that the hrGHr in adults with COH may have protective effects on cardiovascular system.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
85 - 85
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.072How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Isabela Biscotto
AU  - Valeria Costa-Hong
AU  - Luiz Bortolotto
AU  - Luciani Carvalho
PY  - 2018
DA  - 2018/12/04
TI  - P19 EFFECT OF GROWTH HORMONE REPLACEMENT IN THE VASCULAR SYSTEM OF ADULT PATIENTS WITH CHILDHOOD ONSET HYPOPITUITARISM
JO  - Artery Research
SP  - 85
EP  - 85
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.072
DO  - 10.1016/j.artres.2018.10.072
ID  - Biscotto2018
ER  -