Lifestyle modification-induced increase in serum testosterone and SHBG decreases arterial stiffness in overweight and obese men

Hiroshi Kumagai; Asako Miyaki; Ryota Higashino; Nobuhiko Akazawa; Youngju Choi; Song-Gyu Ra; Miki Eto; Kiyoji Tanaka; Ryuichi Ajisaka; Seiji Maeda

doi:10.1016/j.artres.2014.04.003

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Volume 8, Issue 3, September 2014, Pages 80 - 87

Lifestyle modification-induced increase in serum testosterone and SHBG decreases arterial stiffness in overweight and obese men

Authors

Hiroshi Kumagai^a, Asako Miyaki^b, Ryota Higashino^a, Nobuhiko Akazawa^b, Youngju Choi^b, Song-Gyu Ra^a, Miki Eto^b, Kiyoji Tanaka^b, Ryuichi Ajisaka^b, Seiji Maeda^b^{, *}

^aGraduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8577, Japan

^bFaculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8577, Japan

^*Corresponding author. Division of Sports Medicine, Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8574, Japan. Tel.: +81 29 853 2683; fax: +81 29 853 2986. E-mail addresses: kumazin7@gmail.com (H. Kumagai), a.miyaki.velma08@gmail.com (A. Miyaki), h.ryota881216@gmail.com (R. Higashino), von.a.k.a.waz@gmail.com (N. Akazawa), bantomagi@yahoo.co.jp (Y. Choi), ra.song.gyu@gmail.com (S.-G. Ra), eto@stat.taiiku.tsukuba.ac.jp (M. Eto), tanaka@taiiku.tsukuba.ac.jp (K. Tanaka), ajisakas@taiiku.tsukuba.ac.jp (R. Ajisaka), maeda@taiiku.tsukuba.ac.jp (S. Maeda).

Corresponding Author

Seiji Maeda

Received 23 August 2013, Revised 12 February 2014, Accepted 4 April 2014, Available Online 9 May 2014.

DOI: 10.1016/j.artres.2014.04.003 How to use a DOI?
Keywords: Testosterone; Obesity; Lifestyle modification; Arterial stiffness
Abstract: Background: Arterial stiffness—a risk factor for cardiovascular diseases—is more frequently observed in obese men. Moreover, the male sex hormone testosterone has an anti-atherogenic effect. Serum testosterone levels are found to be lower in obese men than in age-matched normal-weight men. However, the effect of lifestyle modification on testosterone in obese men has not been elucidated. Here, we examined the effect of lifestyle modifications on serum testosterone levels and arterial stiffness in overweight and obese men.

Methods: Eleven overweight and obese men (mean age: 53 ± 3 years) completed a 12-week lifestyle modification program. Before and after the program, we measured the mean blood pressure (MBP), carotid-femoral pulse wave velocity (cfPWV; as an index of arterial stiffness), and the serum total testosterone levels in all participants.

Results: We observed a significant weight loss after the 12-week lifestyle modification program. After the program, MBP and cfPWV significantly decreased and serum testosterone levels significantly increased. Moreover, we observed a negative relationship between the change in serum testosterone levels and that in cfPWV, although this relationship was affected by change in MBP.

Conclusions: Lifestyle modification increased the serum testosterone levels in overweight and obese men. The increase in serum testosterone levels was associated with a corresponding reduction in MBP and arterial stiffness. These results suggest that an increase in the testosterone levels may be an important mechanism underlying the beneficial effect of lifestyle modification on arterial stiffness. However, the association may not be direct, but may be mediated by a change in the MBP.
Copyright: © 2014 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 8 - 3
Pages: 80 - 87
Publication Date: 2014/05/09
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2014.04.003 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Hiroshi Kumagai
AU  - Asako Miyaki
AU  - Ryota Higashino
AU  - Nobuhiko Akazawa
AU  - Youngju Choi
AU  - Song-Gyu Ra
AU  - Miki Eto
AU  - Kiyoji Tanaka
AU  - Ryuichi Ajisaka
AU  - Seiji Maeda
PY  - 2014
DA  - 2014/05/09
TI  - Lifestyle modification-induced increase in serum testosterone and SHBG decreases arterial stiffness in overweight and obese men
JO  - Artery Research
SP  - 80
EP  - 87
VL  - 8
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.04.003
DO  - 10.1016/j.artres.2014.04.003
ID  - Kumagai2014
ER  -

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