Viliuisk encephalomyelitis (VE) is a unique endemic disease of the central nervous system, in which neurodegenerative processes are initiated by chronic aseptic subclinical inflammation of the brain. Recent research suggests that the gut microbiome play an important role in immune activation and inflammation...

The adaptation process in the Far North is accompanied by significant changes in the physiological systems of the organism. Malfunctions of regulatory systems significantly alter a person’s ability to adapt to living conditions and cause serious metabolic disorders. The priority of modern medicine is...

The results of comprehensive assessment of health condition in 42 girls aged 11–13 years old who studied at NEFU school-laboratory “Sargelekh” were presented. Only half of girls aged 11–13 years old had average harmonious physical development. The remaining girls were characterized by physical abnormalities:...

The relationship of the state of the human habitat, in particular its chemical composition, with indicators of health and quality of life is well known. However, in medicine, unlike biology, agriculture and a number of other sciences, the study and use of this knowledge remains limited and non-demanded...

Myopia is one of the most relevant problems in pediatrics. One of the starting mechanisms of myopia is accommodation disorders. With an imbalance of autonomic innervation of the ciliary muscle, the process of accommodation is disrupted, which leads to the development and progression of myopia. The purpose...

An assessment of the immune regulation, its cellular and humoral components was carried out for diagnosing early health disorders in potassium production workers affected by excessive contamination of biological media with formaldehyde. The purpose of the article is to study the influence of chemical...

Inpatient care requires far more resources than outpatient care. In this regard, prognosing its needs is a more important component of the resource management of health organizations and the health system as a whole. It is relevant to create demand models for strategic regional planning. The purpose...

A study has been conducted to investigate the relationships between the risk of developing various pathogenetic subtypes of ischemic stroke (IS) and its outcomes with chronic kidney disease (CKD). A retrospective study was conducted in the group of IS patients (n=1070): with CKD (n=343) and without CKD...

The article describes adapted good wishes for preschool children on the example of Yakut algys. At the beginning of the article, authors point to the need to find methods to eliminate anxiety. The aim of this study was to study the variety of Yakut algys and to choose of the most suitable for the application...

On the pandemic background of a new coronavirus infection, the widespread anti-epidemic measures, the situation with other infectious diseases has changed. The purpose of this research was to analyze the incidence of infectious diseases in the Republic of Sakha (Yakutia) during 2020 pandemic. We used...

Inflammatory diseases in the urogenital tract of men living in different climatic conditions often cause infertility. The study aims to assess the antioxidant status and antiradical activity of sperm in men with chronic prostatitis living in the Western Urals. 55 men aged 23 to 38 years with inflammatory...

Colorectal cancer (CRC) is an oncopathology with a large share in the world’s morbidity and mortality. In developed countries with a high level of medicine, over the past decades, there has been a decrease in mortality rates from colorectal cancer, which is due to the introduction of screening programs...

Tick-borne encephalitis is one of the most relevant natural-focal diseases in the Russian Federation. This article describes a clinical case of mixed infection: tick-borne encephalitis and borreliosis in the Republic of Sakha (Yakutia) in a man living in Yakutia. The greatest activity of ticks is in...

172 Yakut patients with confirmed tuberculosis (TB) were included to the study, exploring the possible association between polymorphisms in SLC11A1 and IFNG genes and various clinical forms of TB in patients of Yakut ethnicity. Distributions of single nucleotide polymorphisms (SNPs) were analyzed in...

The study was conducted at the Phthisiatry Research-Practice Center in Yakutsk. 70 hospitalized women with confirmed TB diagnosis and 70 women with ruled out TB were observed. Informed consent was obtained from all participants in compliance with an ethics code. Apparently healthy state with no signs...

In the north, the human body is influenced by a whole complex of climatic, geographic, geophysical, environmental factors of the external environment. These factors have an adverse effect on human health. The health state of the population reflects the living conditions, the state of immune protection...

Anticoid plasma transfusion (AP) is considered to be one of the for COVID-19 treatment. The retrospective study included 73 COVID-19 convalescents who donated plasma of the Blood Transfusion Station in the Republic of Sakha (Yakutia) as potential AP donors. Donors who had a history of COVID-19 infection...

This research aims to establish the reference values of genitometric parameters in young men of the pubertant period living in the Republic of Sakha (Yakutia) and the peculiarities of their relation with somatometric and physiometric indicators. 74 young men of Yakut nationality were examined by standard...

The data of an experimental study in order to determine the toxic dose of positively charged carbon dots (CD) on the culture of fibroblasts are presented. The study used fibroblasts isolated from the dermis of a healthy adult. The experimental part of the work consisted in assessing the morphology of...

The aim of the research is to study modern clinical and epidemic characteristics of tuberculosis patients of early and preschool children in the Republic of Sakha (Yakutia). Traditional methods of assessing the patient’s clinical condition and history have been used. Analysis of radiological and laboratory...

The purpose of the research was to assess the functional state of the cardiovascular system of men in Yakutia of 22–60 years old (depending on the age group). A morphofunctional survey included 295 men of the first mature age (21–35 years old) and 502 men of the second mature age (36–60 years old). An...

The aim of the study was to identify age-related features of body proportions of Yakut men of older age groups. The analysis of the somatometric survey of 591 men of three age groups was carried out: the second mature period, the elderly and the senile ages. The obtained material was processed by the...

On the example of case study, we present the features of the course of AIH on the background of SLE, as well as the difficulties of diagnosis and treatment. The study revealed an immune-mediated combination of autoimmune hepatitis with systemic lupus erythematosus, based on the association of autoimmune...

The aim of this research was to study the course of postcovid syndrome in patients who suffered severe SARS-CoV-2 infection (lung damage from 10 to 40 %). Patients were from 45 to 65 years old. This group of patients was examined by the allergic immunologist. All patients (1000 people) underwent a comprehensive...

We conducted a study of fertile women living in Perm, an industrially developed, ecologically unfavorable city located in close proximity to the non-ferrous metallurgy enterprise with population of 40 thousand people. In this area, there is a problem of air pollution by hormone-like xenobiotics (phenols)....

The article presents the results of experimental studies of interscapular and peri-adrenal brown adipose tissue of rats kept at low temperatures. Experimental animals were kept at a temperature of + 50 °C for 1.3, 7, 15, 30, 90 days. The skin temperature of the lateral surfaces of the body, ears, paws,...

Parameters of life quality in 12 patients with type 1 spinocerebellar ataxia (SCA1) in the Yakut population were studied. The control group was 12 healthy individuals. A SF-36 questionnaire was used to determine life quality, reflecting overall well-being and satisfaction degree with the physical and...

The aim of the study is to develop a technique for machine recognition of the shapes and sizes of scanning electron microscope (SEM) images of erythrocytes of patients with cervical cancer (CC) obtained on a SEM during radiation therapy (RT). The article considers the study of the morphology of erythrocytes...

This article presents the research results of the physical development of 712 adolescents aged 15-16 years old and the updated regional standard for the physical development of adolescents in Yakutia. The body length and weight, the circumference of the chest, waist and thigh were measured. According...

A comparative genetic examination of children with varying degrees of asthenization of the nervous system, living in the Far North of Russia was carried out. The polymerase chain reaction method on BioRAD CFX96 Real Time System was used to study the following polymorphisms: A1166C of AGTR1 angiotensin...

The article presents the prevalence of tobacco smoking based on the results of the anonymous questionnaire and cotinine test. Tobacco use is a major risk factor for a range of chronic diseases, including cancer, lung disease and cardiovascular disease. It has been proven that the respiratory system (larynx,...

Despite significant advances in the treatment of congenital malformations in newborns, there is still a fairly high mortality rate in the group of newborns with congenital diaphragmatic hernia. This fact is associated with the high incidence of concomitant pulmonary hypertension in newborns with lung...

The work investigated the immediate and distant consequences of the introduction of Cortineff. Cortineff, as a derivative of corticosteroids, has both mineral- and glucocorticoid properties. Moreover, its predominant effects are mineralocorticoid. The injection of Cortineff to pregnant rats caused a...

Excessive exposure to anthropogenic environmental factors on the territory of chemical production enterprise causes changes in the microelement composition of biological media of the child population characterized by an increased level of blood contamination with benzo(a)pyrene and phenol (p <0.05),...

Visceral disorders of various organs and systems in children with connective tissue dysplasia (CTD) living in extreme climatogeographic conditions according to laboratory tests have been studied. The children (35 schoolchildren) aged 10 to 17 years old were divided into mild, moderate and pronounced...

The article presents the results of the first genome-wide research that purposefully analysed the Yakut genome. The structural features of the genomic DNA molecule (the number and characteristics of SNPs, Indels, CNV, and SD) and gene variants characteristic of the Yakut ethnic group are shown. The frequency...

The problem of artificial abortions of pregnancy, especially in the first trimester, is extremely promising in modern medical practice. The relevance of the issue of abortions is the risk of fatal complications. The purpose was to a comparative assessment of the results of medicinal and operational abortion...

The present article describes a case of a successful outcome of post-resuscitation disease after prolonged cardiopulmonary resuscitation (CPR) at the prehospital stage in a patient with clinical death due to hypothermia. The unknown, a young man, was admitted to the Emergency Medical Center by an emergency...

Esophageal atresia is a congenital anomaly in which the oral end of the esophagus ends in a pouch. Its frequency is 1 in 2500–4500 newborns. Esophageal atresia is considered a complex malformation; the results of its treatment are used to judge the level of surgical care provided by the medical institution....

171 employees exposed to industrial anthropogenic chemical factors were examined. The sample was divided according to the principle of the presence of the cardiovascular diseases (CVD) (study group – 115 people) and their absence (comparison group – 56 people). For all employees, a chemical-analytical...

Morphometric indices, structural components in fetuses and newborns were studied depending on gestation and morphofunctional variant. The object of the study was 130 thyroid glands obtained from fetuses and deceased newborns, from 22 full to 40 weeks of gestation. The average thyroid volume in fetuses...

Endothelial NOS (nitric oxide synthase 3) is an enzyme that synthesizes nitric oxide, which in turn plays a crucial role in regulating vascular tone, cell proliferation, leukocyte adhesion, and platelet aggregation. This enzyme in humans is encoded by NOS3 gene. The aim of our research was to study T...

Under conditions of intensive industrial impact, the study of the specifics of the regulatory systems response will benefit effective implementation of measures aimed to preserve the health of the child population. We have studied the indicators of the immune status of schoolchildren at different levels...

Analysis of spectral power and EEG rhythm index in Yakut students (n=38) was carried out. Higher spectral power values of base alpha rhythm were noted, relatively slow wave teta- and delta-activity. Regardless of the lateralization of the dominant hand, the decreasing occipital-frontal gradient of the...

The state of health of children is one of the indicators of the quality of the environment, social well-being and the level of health of the country. The purpose of this study was to assess the physical development of children and adolescents. To assess the physical development of children and adolescents...

A comparison of electronic database of patients’ visits complaints to ambulance (ECM) in Yakutsk was made to assess the impact of space weather on the well-being and condition of people with cardiovascular pathology. It has been shown that during the years of high solar activity there are significant...

To achieve the proper level of accessibility and quality of medical care to the population, the provision of the municipalities of the republic with the necessary resources (material, technical, financial, human, information, etc.) is of no small importance. In this work, we analyzed the resource provision...

The analysis of patients with cholelithiasis for the period from 21.12.2017 to 20.12.2018 was carried out. The increased number of patients with complicated cholecystitis was 49.59 %, mechanical jaundice – 35.9 % and gallstone pancreatitis – 20 %. Moreover, destructive forms are more often present in...

Despite a wide study of connective tissue dysplasia (CTD), this problem remains unresolved, since this hereditary collagenopathy has a wide range of common and local phenotypic manifestations. The deep (Gothic) palate is most often diagnosed in the structure of CTD local manifestations, which is accompanied...

Multiple hereditary exostoses (MHE) is a genetically heterogeneous disease with an autosomal dominant type of inheritance, a very large proportion of family cases. The incidence of the disease in various Caucasian populations is from 1.3 to 2 per 100 thousand. The clinical picture is characterized by...

There is no HBsAg in the presence of HBV replication in patients with chronic viral hepatitis. This phenomenon was called occult hepatitis B. Russian researches referred as “hidden HBV infection”. We conducted a clinical analysis of the medical history of patient I. with chronic HBV infection in the...

SOPH syndrome (SOPH; MIM# 614800) is a rare hereditary monogenic disease caused by a mutation in the NBAS gene. The clinical spectrum of this disease affects many symptoms such as skeletal dysplasia, atrophy of the optic nerves, Pelger’s leukocyte abnormality. While the somatic manifestations of this...

One of the many complications of endocrine disease such as diabetes is diabetic retinopathy. As a rule, the severity of retinopathy depends on the duration of diabetes mellitus, blood glucose concentration and blood pressure level. The aim of the study was to investigate the influence of genetic factors...

The aim of the work was to determine the functional properties and efficiency of a reagent kit for determining the mutation status of the NRAS gene by allele-specific real-time PCR in human genomic DNA samples. These samples were taken from paraffin-fixed tissue samples (Test-NRAS-tissue) according to...

The problem of waste management of medical and preventive institutions (MPI) in the Russian Federation in modern conditions is considered as an important epidemiological and environmental component of the safety of the population of the country. Since 1979, the World Health Organization has classified...

During pregnancy, a woman is more susceptible to magnesium deficiency, due to an increase in the need for this trace element. Magnesium is essential for the normal course of the processes of mitosis and meiosis, which is the key to the formation of a genetically healthy embryo. Disruption of the processes...

This article examines the dynamics of the opisthorchiasis incidence in various districts of the Khanty–Mansiysk Autonomous Okrug–Yugra. Statistical data processing was carried out using generally accepted methods of variation statistics. All considered factors were considered for 2018. Correlation-regression...

The immune system is a unique defence mechanism. Due to the well-coordinated work of the entire functional immune system, the body can resist numerous amounts of negative factors. Cold exposure is one of the factors that negatively impact the body. The effect of experimental cold stress on the morphofunctional...

A persistence ability is the capacity of pathogenic and opportunistic bacteria to survive in the aggressive internal environment of a macroorganism and is an important feature for these groups of microorganisms. The paper aims to establish whether the target Citrobacter cultures, once isolated from home-produced...

Fruits and vegetables are a valuable source of biologically active substances (vitamins, mineral salts, P-active substances, fiber, pectin and other vital ingredients). Currently, a huge number of varieties with a set of economically valuable features have been created for industrial and amateur gardening....