Influence of Carbon Points on Human Dermal Fibroblasts
- DOI
- 10.2991/ahsr.k.220103.019How to use a DOI?
- Keywords
- carbon points; carbon dots; dermal fibroblasts; toxic effect
- Abstract
The data of an experimental study in order to determine the toxic dose of positively charged carbon dots (CD) on the culture of fibroblasts are presented. The study used fibroblasts isolated from the dermis of a healthy adult. The experimental part of the work consisted in assessing the morphology of fibroblasts depending on the concentration of the CD solution. For this purpose, 5 experimental and 1 control groups were formed. In the experimental groups, CD-solution was added in an increasing concentration – from 24.15 to 120.75 μg/ml. In the 5th and 6th groups, with a solution concentration of 96.6 and 120.75 μg/ml, respectively, signs of fibroblast destruction (cell fragments) appeared, with a characteristic devastation in the center of the visual field, with fragments of destroyed cells on the periphery. Fibroblasts with signs of destruction in the 5th group accounted for more than 20 %, in the 6th – more than 30 %. Thus, we have identified the minimum concentration of the CD solution, which has a toxic effect on human dermal fibroblasts, which was 96.6 μg/ml.
- Copyright
- © 2022 The Authors. Published by Atlantis Press International B.V.
- Open Access
- This is an open access article under the CC BY-NC license.
Cite this article
TY - CONF AU - A.S. Golderova AU - I.E. Nikolaeva AU - I.P. Troev AU - M.N. Egorova AU - S.S. Shadrina PY - 2022 DA - 2022/01/17 TI - Influence of Carbon Points on Human Dermal Fibroblasts BT - Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021) PB - Atlantis Press SP - 90 EP - 94 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.220103.019 DO - 10.2991/ahsr.k.220103.019 ID - Golderova2022 ER -