Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)

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The Intestinal Microbiome of Viliuisk Encephalomyelitis Patients and Its Role in the Pathogenesis of the Disease

Authors
Tatyana Mikhailovna Sivtseva1, *, Galina Grigorievna Karganova2, Vladimir Leonidovich Osakovskiy1
1North-Eastern Federal University, Research Center of the Medical Institute, 677027 Yakutsk, Republic of Sakha (Yakutia), Russian Federation
2Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, 108819, Moscow, Russian Federation
*Corresponding author. Email: tm.sivtseva@s-vfu.ru
Corresponding Author
Tatyana Mikhailovna Sivtseva
Available Online 17 January 2022.
DOI
10.2991/ahsr.k.220103.001How to use a DOI?
Keywords
intestinal microbiome; VE; encephalomyelitis; pathogenesis
Abstract

Viliuisk encephalomyelitis (VE) is a unique endemic disease of the central nervous system, in which neurodegenerative processes are initiated by chronic aseptic subclinical inflammation of the brain. Recent research suggests that the gut microbiome play an important role in immune activation and inflammation in a variety of neurological conditions, including multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. The article discusses the results of a pilot study of the intestinal microbiome of healthy representatives of the Sakha ethnic group (Yakuts) and VE patients, carried out in collaboration with the Institute of Gene Biology of the Russian Academy of Sciences and the Atlas-Biomed Group – Knomics LLC. In the stool samples of VE patients the level of g.Prevotella, g.Faecalibacterium, f.Ruminococcaeae, as well as other unclassified members of o.Clostridiaceae was reduced. A significant increase in the proportion of bacteria g.Akkermansia, archaea Methanobrevibacter, and, on the verge of significance, of the families Christensenellaceae and Mogibacteriaceae was revealed. Analysis of the associations of the gut microbiome and the disease using the selbal algorithm showed a tendency for the association of VE with Methanobrevibacter, which is represented by M. smithii and one or more unclassified genera of the Coriobacteriaceae family. The revealed features of the taxonomic composition of intestinal microbiome in VE patients contribute to the development of a chronic subclinical inflammatory process, as well as pathological lipogenesis.

Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

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Volume Title
Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)
Series
Advances in Health Sciences Research
Publication Date
17 January 2022
ISBN
10.2991/ahsr.k.220103.001
ISSN
2468-5739
DOI
10.2991/ahsr.k.220103.001How to use a DOI?
Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

Cite this article

risenwbib
TY  - CONF
AU  - Tatyana Mikhailovna Sivtseva
AU  - Galina Grigorievna Karganova
AU  - Vladimir Leonidovich Osakovskiy
PY  - 2022
DA  - 2022/01/17
TI  - The Intestinal Microbiome of Viliuisk Encephalomyelitis Patients and Its Role in the Pathogenesis of the Disease
BT  - Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)
PB  - Atlantis Press
SP  - 1
EP  - 4
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.220103.001
DO  - 10.2991/ahsr.k.220103.001
ID  - Sivtseva2022
ER  -