Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)

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The Features of Polymorphism of Detoxification Phase I and II Genes in Women with Infertility Contaminated with Exogenous Phenol

Authors
O.A. Kazakova1, *, V.B Alekseev2, O.V. Dolgikh3
1Department of immunobiological diagnostic methods Federal Scientific Research Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia
2Director of FBSI Federal Scientific Research Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia
3Department of immunobiological diagnostic methods Federal Scientific Research Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia
*Corresponding author. Email: chakina2011@yandex.ru
Corresponding Author
O.A. Kazakova
Available Online 17 January 2022.
DOI
10.2991/ahsr.k.220103.025How to use a DOI?
Keywords
genes polymorphism; detoxification; infertility; exogenous phenol
Abstract

We conducted a study of fertile women living in Perm, an industrially developed, ecologically unfavorable city located in close proximity to the non-ferrous metallurgy enterprise with population of 40 thousand people. In this area, there is a problem of air pollution by hormone-like xenobiotics (phenols). The issue of the role of candidate genes polymorphism in the development of reproductive disorders is especially for the modern metropolis. The observation group consisted of 37 women with spontaneous abortion, the comparison group was formed by 41 conventionally healthy women. All women live under the aerogenic phenol pollution (more than 1.0 MPC s.w. and m.p). The groups are comparable in terms of age, social status and race. In both groups, the levels of phenol in the blood was detected by the method of capillary gas chromatography on the “Crystal 5000”; polymorphism of genes CYP1A1 rs1048943 Ile462Val, CYP1A1_3 rs4646421 C6310T, GSTA4 rs3756980 T / C, GSTP1 rs1695 Ile105Val, GSTP1 rs1138272 Ala114Val was determined by real-time polymerase chain reaction CFR 96. Statistical data were processed in Statistica 10.0. The groups significantly differed in terms of the level of phenol in the blood, relative to the upper limit of the norm (p <0.05). An analysis of the Multiplicative Inheritance Model revealed the A allele of the CYP1A1 rs1048943 Ile462Val gene (p <0.05) and the A allele of the GSTP1 rs1695 Ile105Val gene (p <0.05) as a factor associated with the likelihood of spontaneous abortion under the excessive exogenous estrogenation Phenol.

Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

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Volume Title
Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)
Series
Advances in Health Sciences Research
Publication Date
17 January 2022
ISBN
10.2991/ahsr.k.220103.025
ISSN
2468-5739
DOI
10.2991/ahsr.k.220103.025How to use a DOI?
Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

Cite this article

risenwbib
TY  - CONF
AU  - O.A. Kazakova
AU  - V.B Alekseev
AU  - O.V. Dolgikh
PY  - 2022
DA  - 2022/01/17
TI  - The Features of Polymorphism of Detoxification Phase I and II Genes in Women with Infertility Contaminated with Exogenous Phenol
BT  - Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)
PB  - Atlantis Press
SP  - 123
EP  - 127
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.220103.025
DO  - 10.2991/ahsr.k.220103.025
ID  - Kazakova2022
ER  -