Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)

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Pathogenetic Subtypes and Ischemic Stroke Outcomes in Patients with Chronic Kidney Disease

Authors
Sargylana A. Chugunova1, *, Tuyara S. Egorova2
1M.K. Ammosov North-Eastern Federal University, 27, Oyunsky St, Yakutsk, 677000, Russia
2Republic Hospital No. 2 – Emergency Center, 83A, P. Alekseeva St., Yakutsk, 677005, Russia
Corresponding author. Email: sa.chugunova@mail.ru
Corresponding Author
Sargylana A. Chugunova
Available Online 17 January 2022.
DOI
10.2991/ahsr.k.220103.008How to use a DOI?
Keywords
pathogenetic subtypes; ischemic stroke outcomes; chronic kidney disease
Abstract

A study has been conducted to investigate the relationships between the risk of developing various pathogenetic subtypes of ischemic stroke (IS) and its outcomes with chronic kidney disease (CKD). A retrospective study was conducted in the group of IS patients (n=1070): with CKD (n=343) and without CKD (n=727). TOAST classification was used to determine IS subtypes. The study data showed that in patients with CKD compared to patients without CKD, TOAST2 frequency was more common in total group (p<0.0001; OR=1.878 (1.423–2.478)), among men (p<0.001; OR=2.008 (1.370–2.943)) and among women (p=0.009; OR=1.720 (1.145–2.584)); TOAST1 frequency was rare in total group (p<0.0001; OR=0.565 (0.435–0.734)), among men (p<0.0001; OR=0.502 (0.353–0.713)) and among women (p=0.042; OR=0.665 (0.448–0.487)); stroke manifestations were more severe an NIHSS scale (p=0.0001), Glasgow coma scale (p=0.002); IS mortality was higher (13.7 % versus 7.4 %; p=0.001; OR=1.979 (1.308–2.994) in total group and TOAST2 mortality was higher (25.0 % vs.14.9 %; p=0.027; OR=1.910 (1.072–3.404) in total group and among women (29.7 % versus 11.1 %; p=0.004; OR=3.378 (1.446–7.890)). Conclusions. IS patients with CKD are more likely to develop cardioembolic stroke (p<0.0001; OR=1.878 (1.423–2.478)), have more severe stroke manifestations (NIHSS score, p=0.0001; Glasgow score, p=0.002), have higher cardioembolic stroke mortality among women (29.7 % versus 11.1 %; p=0.004; OR=3.378 (1.446–7.890) compared to IS patients without CKD.

Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

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Volume Title
Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)
Series
Advances in Health Sciences Research
Publication Date
17 January 2022
ISBN
978-94-6239-513-8
ISSN
2468-5739
DOI
10.2991/ahsr.k.220103.008How to use a DOI?
Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

Cite this article

risenwbib
TY  - CONF
AU  - Sargylana A. Chugunova
AU  - Tuyara S. Egorova
PY  - 2022
DA  - 2022/01/17
TI  - Pathogenetic Subtypes and Ischemic Stroke Outcomes in Patients with Chronic Kidney Disease
BT  - Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)
PB  - Atlantis Press
SP  - 36
EP  - 42
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.220103.008
DO  - 10.2991/ahsr.k.220103.008
ID  - Chugunova2022
ER  -