Immune Status of Children Living in Industrial Developed Regions in the Conditions of Chronic Exposition of Anthropogenic Chemical Factors (by the Example of Benz(a)pyren, Phenol and Mercury)

DOI

10.2991/ahsr.k.220103.034How to use a DOI?

Keywords

Immune status; industrial developed regions; anthropogenic chemical factors; child population

Abstract

Excessive exposure to anthropogenic environmental factors on the territory of chemical production enterprise causes changes in the microelement composition of biological media of the child population characterized by an increased level of blood contamination with benzo(a)pyrene and phenol (p <0.05), as well as an excess mercury concentration in urine in relation to the control group. The immune status of the group under study is characterized by an increase in the level of hapten-specific sensitization to man-made chemical factors in a given territory according to the criterion of IgG to phenol, IgG to benzo(a)pyrene, IgG to epichlorohydrin and IgG to mercury (p<0.05). The revealed decrease in the content of CD3⁺CD4⁺- and CD3⁺CD8⁺-lymphocytes resulting in the immunoregulatory index of CD4⁺/CD8⁺, as well as inhibition of the phagocytic activity of leukocytes according to the criteria of a decrease in the percentage of phagocytosis, phagocytic number, phagocytic index and absolute phagocytosis indicate the development of immunodeficiency links of innate and acquired immunity among children under study. The established features of immune regulation (overproduction of IgG to phenol, IgG to benzo(a)pyrene, IgG to epichlorohydrin and IgG to mercury; deficiency of CD3⁺CD4⁺- and CD3⁺CD8⁺-) against the background of increased contamination of biological media with benz(a)pyrene, phenol and mercury characterizes the immune status peculiarities of the child population living under conditions of excessive haptenic load, and are recommended as marker indicators for early diagnosis of health disorders associated with the immune system.

Copyright

© 2022 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

Download article (PDF)

TY  - CONF
AU  - N.A. Nikonoshina
AU  - O.V. Dolgikh
AU  - N.V. Zaitseva
PY  - 2022
DA  - 2022/01/17
TI  - Immune Status of Children Living in Industrial Developed Regions in the Conditions of Chronic Exposition of Anthropogenic Chemical Factors (by the Example of Benz(a)pyren, Phenol and Mercury)
BT  - Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)
PB  - Atlantis Press
SP  - 167
EP  - 171
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.220103.034
DO  - 10.2991/ahsr.k.220103.034
ID  - Nikonoshina2022
ER  -