Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)

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Analysis of Association Between Various Clinical Forms of Tuberculosis and SLC11A1 and IFNG Gene Polymorphisms in Individuals of Yakut Ethnicity

Authors
M.V. Egorova1, L.I. Mordovskaya1, 2, *, T.M. Klimova2, V.V. Gerasimova2, 3, A.R. Ermolaev3
1Phthisiatry Research-Practice Center name by.E.N. Andreev, 93, P. Alexeev str., Yakutsk
2Medical Institute, M.K. Ammosov North-Eastern Federal University name by M.K. Ammosov. 27, Oyunskogo str, Yakutsk.
3Blood Transfusion Center, 85. P. Alexeev str., Yakutsk
*Corresponding author. Email: mordovskaya.li@s-vfu.ru
Corresponding Author
L.I. Mordovskaya
Available Online 17 January 2022.
DOI
10.2991/ahsr.k.220103.014How to use a DOI?
Keywords
tuberculosis; SLC11A1 and IFNG gene polymorphisms; Yakut ethnicity
Abstract

172 Yakut patients with confirmed tuberculosis (TB) were included to the study, exploring the possible association between polymorphisms in SLC11A1 and IFNG genes and various clinical forms of TB in patients of Yakut ethnicity. Distributions of single nucleotide polymorphisms (SNPs) were analyzed in Yakut patients, in SLC11A1 gene Asp543Asn locus, in IFNG gene T6000A and T8360C loci, in relation to disease extent, clinical progression pattern, culture test results, presence of necrotic cavities. No association was detected between polymorphisms in genes SLC11A1 (rs17235409) or IFNG (rs2430561, rs2069718) and disease localization, clinical form, culture test result, or clinical progression pattern in patients with TB.

Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

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Volume Title
Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)
Series
Advances in Health Sciences Research
Publication Date
17 January 2022
ISBN
10.2991/ahsr.k.220103.014
ISSN
2468-5739
DOI
10.2991/ahsr.k.220103.014How to use a DOI?
Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

Cite this article

risenwbib
TY  - CONF
AU  - M.V. Egorova
AU  - L.I. Mordovskaya
AU  - T.M. Klimova
AU  - V.V. Gerasimova
AU  - A.R. Ermolaev
PY  - 2022
DA  - 2022/01/17
TI  - Analysis of Association Between Various Clinical Forms of Tuberculosis and SLC11A1 and IFNG Gene Polymorphisms in Individuals of Yakut Ethnicity
BT  - Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)
PB  - Atlantis Press
SP  - 67
EP  - 71
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.220103.014
DO  - 10.2991/ahsr.k.220103.014
ID  - Egorova2022
ER  -