Artery Research

Latest Articles

Research Article

Birth Weight in Relation to Post-Natal Growth Patterns as Predictor of Arterial Stiffness and Central Hemodynamics in Young Adults from a Population-based Study

Johannes Sperling, Shantanu Sharma, Peter M. Nilsson
In Press, Corrected Proof, Available Online: 20 February 2021
Objective: Our aim was to examine the impact of mismatch patterns reflecting pre- and post-natal growth conditions on markers of arterial stiffness and central hemodynamics in young adults. Methods: In all, 1056 participants from Malmö Offspring Study, 484 men and 572 women (age-range 18–44 years),...
Research Article

Therapeutic Effects of Interventional Therapy and Conservative Therapy on Lower Extremity Arteriosclerosis Obliterans and Risk Factors for Prognosis

Lingxiong Chen, Xuming Zhang, Fuyan Jiang, Zhida Yin, Jinqiu Xue, Chengmei Ruan, Lijiao Xie
In Press, Uncorrected Proof, Available Online: 13 February 2021
Background: Arteriosclerosis Obliterans (ASO) is an important cause for lower limb amputation. We aimed to compare the effects of interventional and conservative therapies on lower extremity ASO, and to analyze the risk factors for prognosis. Methods: Ninety-eight eligible patients were randomly divided...
Research Article

KCa3.1 Inhibition Decreases Size and Alters Composition of Atherosclerotic Lesions Induced by Low, Oscillatory Flow

Darla L. Tharp, Douglas K. Bowles
In Press, Uncorrected Proof, Available Online: 13 February 2021
Low, oscillatory flow/shear patterns are associated with atherosclerotic lesion development. Increased expression of KCa3.1 has been found in Vascular Smooth Muscle (VSM), macrophages and T-cells in lesions from humans and mice. Increased expression of KCa3.1, is also required for VSM cell proliferation...
Research Article

Reliability of Finger Photoplethysmogram Assessment: Effect of Mental Stress and Day-to-Day Variability

Marina Fukuie, Takashi Tarumi, Takayuki Yamabe, Jun Sugawara
In Press, Uncorrected Proof, Available Online: 13 February 2021
Frequent assessment of vascular health (e.g., arterial stiffness) may predict the incidence of cardiovascular disease. The Second Derivative of the finger Photoplethysmogram Aging Index (SDPTGAI) may be used as an index of vascular aging and a screening tool for arteriosclerotic disease. To test its...
Research Article

Differential Sensitivity of Brachial-Ankle Pulse Wave Velocity and Ankle-Brachial Index for Cardiovascular Risk Assessment in Elderly Chinese: A Cross-Sectional Study

Guoxiang Fu, Yuan Zhong, Fengfeng Pan, Chanchan Xu
In Press, Corrected Proof, Available Online: 8 January 2021
Background: Brachial-Ankle Pulse Wave Velocity (baPWV) and Ankle-Brachial Index (ABI) are widely used in clinic for evaluating arterial stiffness and atherosclerosis separately. This study aimed to compare the sensitivity of baPWV and ABI for cardiovascular risk assessment in elderly Chinese. Methods:...
Research Article

Central Blood Pressure in Young Kendo Athletes: Implications of Combined Anaerobic and Strength Training

Masaki Yoshioka, Kaname Tagawa, Yuriko Tochigi, Tomohito Sato, Jiyeon Park, Reiko Momma, Youngju Choi, Jun Sugawara, Seiji Maeda
In Press, Corrected Proof, Available Online: 8 January 2021
Background: Exercise training-induced adaptation of central Blood Pressure (BP) depends on exercise mode. Kendo, a traditional Japanese martial art, is a unique exercise mode because its training encompasses anaerobic and resistance training components. However, the effects of habitual kendo training...
Research Article

Homebased Standing Core Exercise Training Improves Femoral Blood Flow but not Arterial Stiffness in Middle-Aged to Older Adults

Hsin-Fu Lin, Soun-Cheng Wang, Hao-Min Cheng, Jun Sugawara
In Press, Corrected Proof, Available Online: 8 January 2021
Homebased exercise is often advocated to improve physical fitness in the aging population, especially when outdoor activity is not available. Yet we often have a limited understanding of its training effects for clinical uses. Aim: To investigate a short-term exercise training of standing core exercise...
Conference Abstract

P.61 Impact of Kidney Transplantation on Arterial Reservoir-Wave Analysis

Nadège Côté, Emy Philibert, Mathilde Paré, Rémi Goupil, Catherine Fortier, Martin G. Schultz, James E. Sharman, Mohsen Agharazii
Volume 26, Issue Supplement 1, December 2020, Pages S84-S84
Purpose/Background/Objective: According to reservoir-wave approach (RWA) arterial pressure is the sum of a reservoir pressure (RP) accounting for dynamic storage and release of blood from arteries, and an excess pressure (XSP) analogous to flow. RP is the minimal left ventricular work required to generate...
Conference Abstract

P.62 Assessment of Isoflavone and Ethanolic Extract of Inonotus Obliquus on Experimentally Induced Diabetes

Kingsley Duru, Cara Hildreth, Alberto P. Avolio, Jacqueline K. Phillips, Mark Butlin
Volume 26, Issue Supplement 1, December 2020, Pages S85-S85
Purpose: Studies support beneficial effects of isoflavones, but antidiabetic effects of these agents remains unconfirmed [1,2]. This pilot study investigates isoflavones and Inonotus obliquus (chaga) extract effects on diabetes. Methods: Diabetes was induced (streptozotocin 65 mg/kg, nicotinamide 110...
Conference Abstract

P.60 Improvement in Muscular Strength Within One Year is Associated with Increased Arterial Stiffness in Young Male Soccer Players

MPH Lisa Baumgartner, Heidi Weberruß, Katharina Appel, Tobias Engl, Renate Oberhoffer-Fritz, Thorsten Schulz
Volume 26, Issue Supplement 1, December 2020, Pages S83-S83
Purpose: The adaptation process of the cardiovascular system to exercise and muscular strength in young athletes is unclear. Therefore, we investigated the influence of changes in muscular strength and weekly training load within one year on arterial stiffness in young male soccer players. Methods:...
Conference Abstract

P.63 Sarcopenia and Atherosclerotic Occlusive Disease: How Much We Know and What We Need to Know About this Association?

Joana Ferreira, Alexandre Carneiro, Pedro Cunha, Armando Mansilha, Isabel Vila, Cristina Cunha, Cristina Silva, Adhemar Longatto-Filho, Maria Correia-Neves, Gustavo Soutinho, Luís Meira-Machado, Amilcar Mesquita, Jorge Cotter
Volume 26, Issue Supplement 1, December 2020, Pages S86-S87
Purpose/Background: Sarcopenia (decrease of muscle mass and function) has been linked with atherosclerosis [1]. The EWGSOP2 updated consensus, uses low muscle strength as the primary indicator of sarcopenia [2]. It is acknowledged that strength is better than mass for predicting adverse outcomes [2]....
Conference Abstract

P.64 Active Vitamin D Treatment Does Not Improve Arterial Stiffness and Markers of Cardio-Renal Risk in Patients with Type 2 Diabetes and Stage 3 Chronic Kidney Disease: a Randomised Controlled Trial

Nikolaos Fountoulakis, Salma Ayis, Anastasios Mangelis, Angeliki Panagiotou, Maria Flaquer, Stanimir Stoilov, Giuseppe Maltese, GianCarlo Viberti, Stephen Thomas, Luigi Gnudi, Janaka Karalliedde
Volume 26, Issue Supplement 1, December 2020, Pages S88-S88
Background and Aims: Active vitamin D [1,25(OH)2D3] deficiency is a potential modifiable risk factor for cardiovascular (CVD) and renal disease in patients with type 2 diabetes (T2DM) and stage 3/4 chronic kidney disease (CKD). Exact mechanisms are unclear. Arterial stiffness is an independent predictor...
Conference Abstract

P.68 WaveGraft–A Novel Endovascular Device Concept for Restoring the Natural Arterial Cushioning Effect

Florian Stefanov, Dave Veerasingam, Sarah Sayed, Patrick Delassus, Jonathan Bouchier-Hayes, Liam Morris
Volume 26, Issue Supplement 1, December 2020, Pages S92-S92
Background and Objectives: The cushioning effect of large, healthy arteries reduces pulsatile afterload to the heart, reduces pulsatility in the microvasculature of target organs, and promotes coronary/cerebral perfusion [1]. With age, large arteries become stiffer, which increases both pulse wave velocity...
Conference Abstract

P.65 Increased Biomarkers of Endothelial Dysfunction and Thrombotic Microenvironment in Patients with Autoimmune Rheumatic Disorders Free from Cardiovascular Comorbidities

Eleni Gavriilaki, Panagiota Anyfanti, Stella Douma, Eugenia Gkaliagkousi
Volume 26, Issue Supplement 1, December 2020, Pages S89-S89
Purpose/Background/Objectives: Cardiovascular risk is increased in patients with autoimmune rheumatic disorders [1]. Endothelial and platelet MVs (EMVs, PMVs) are small vesicles (0.1–1 μm) released from plasma membrane and represent novel markers of endothelial dysfunction and thrombosis. Their levels...
Conference Abstract

P.66 Radial Artery Systolic-Diastolic Pulse Transit Time After Kidney Transplantation

Emy Philibert, Hasan Obeid, Mathilde Paré, Nadège Côté, Catherine Fortier, Rémi Goupil, Mohsen Agharazii
Volume 26, Issue Supplement 1, December 2020, Pages S90-S90
Purpose/Background/Objective: We have previously shown that restoration of kidney function through kidney transplantation (KTx) is associated with improved aortic stiffness. In this study, we aim to examine whether this change in aortic stiffness translates into improvement of radial artery systolic-diastolic...
Conference Abstract

P.67 The Effects of Chemotherapy on Arterial Inflammation Assessed by 18FDG PET-CT in Patients with Lymphoma

Constantinos Anagnostopoulos, Stavroula Giannouli, Nikolaos Ioakimidis, Paulos Kafouris, Iosif Koutagiar, Anastasia Sioni, Eirini Solomou, Dimitrios Terentes-Printzios, Dimitrios Tousoulis, Charalampos Vlachopoulos
Volume 26, Issue Supplement 1, December 2020, Pages S91-S91
Introduction: Anti-cancer treatment can lead to increased cardiovascular morbidity among lymphoma survivors [1]. This may be the result of direct effect of treatment on heart function, or indirect acceleration of atherosclerosis. 18F-fluorodeoxyglucose (FDG) uptake is a sensitive and robust marker for...
Conference Abstract

P.56 Differences in Vascular Effects Between One Session of Moderate-Intensity Continuous Physical Exercise and High-Intensity Interval Physical Exercise in Individuals with High Blood Pressure

Sara Rodrigues, Renata G S Verardino, Marcel J A Costa, Ana Luíse Duenhas-Berger, Valéria Costa-Hong, Luiz A Bortolotto
Volume 26, Issue Supplement 1, December 2020, Pages S78-S78
Purpose: To compare augmentation index (AIx) between one Moderate-intensity continuous physical exercise (MICPE) and one High-intensity interval physical exercise (HIIPE) session in normal/high normal blood pressure (BP) (120–140 for systolic and 80–90 mmHg for diastolic). Additionally, to compare two...
Conference Abstract

P.53 Ascending Aorta Diameter and Pulse Wave Velocity are Increased and Local Hemodynamic is Disrupted in Patients with Blunt Traumatic Thoracic Aortic Injury Treated by TEVAR

Andrea Guala, Daniel Gil Sala, Aroa Ruiz-Muñoz, Marvin Garcia-Reyes, Lydia Dux-Santoy, Gisela Teixido-Tura, Cristina Tello, Filipa Valente, Angela Lopez-Sainz, Laura Galian, Laura Gutierrez, Kevin Johnson, Oliver Wieben, Ignacio Ferreira, Arturo Evangelista, Sergi Bellmunt-Montoya, Jose Rodriguez-Palomares
Volume 26, Issue Supplement 1, December 2020, Pages S74-S75
Background: Thoracic endovascular aortic repair (TEVAR) is becoming the preferred treatment option to repair the proximal descending aorta after rupture following blunt traumatic injury. However, hemodynamic and mechanic implications of this intervention are poorly understood. Exploiting the possibilities...
Conference Abstract

P.54 Biomarkers and Haemodynamic Predictors of Left Atrial Strain in Early Hypertension

Maryam Bukhamseen, Nada Al-Saileek, Ahmed Al-Saileek, Mohammad Ghormalla Ghamdi, Tahlil Wasame, Ahmed Omran, Azra Mahmud
Volume 26, Issue Supplement 1, December 2020, Pages S76-S76
Background: In the early stages of atrial remodeling, increased aortic stiffness might indicate atrial fibrosis. Objective: This study aimed to investigate the association between left atrial (LA) mechanical function, assessed by two-dimensional speckle tracking echocardiography and aortic stiffness...
Conference Abstract

P.50 Radial Artery Phenotyping in Fibromuscular Dysplasia Through Ultra-High Frequency Ultrasound: A Radiomic Approach

Federica Poli, Rosa Maria Bruno, Francesco Faita, Hakim Khettab, Michel Azizi, Saverio Vitali, Mirco Cosottini, Davide Caramella, Lorenzo Ghiadoni, Stefano Taddei, Pierre Boutouyrie, Alexandre Persu, Xavier Jeunemaitre, Aurélien Lorthioir
Volume 26, Issue Supplement 1, December 2020, Pages S73-S73
Rationale and Aim: This study is aimed at identifying possible patterns of vascular wall disarray and remodeling in radial arteries of patients with fibromuscular dysplasia (FMD), by means of ultrahigh frequency ultrasound (UHFUS). Methods: UHFUS scans of the radial arteries and of 30 FMD patients and...
Conference Abstract

P.57 Acetylsalicylic Acid Reduces Passive Aortic Wall Stiffness and Cardiac Remodelling in a Mouse Model of Advanced Atherosclerosis

Lynn Roth, Wim Martinet, Guido R.Y. De Meyer
Volume 26, Issue Supplement 1, December 2020, Pages S79-S80
Background: Acetylsalicylic acid (ASA) is used in secondary prevention of cardiovascular disease (CVD) because of its antithrombotic effects. We investigated whether ASA has additional therapeutic value by preventing the progression of inflammation and cardiovascular remodelling in mice with stable atherosclerosis...
Conference Abstract

P.58 Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice

Bart Spronck, Marcos Latorre, Sameet Mehta, Alexander W. Caulk, Abhay B. Ramachandra, Sae-Il Murtada, Alexia Rojas, Chang-Sun He, Bo Jiang, Mo Wang, Matthew R. Bersi, George Tellides, Jay D. Humphrey
Volume 26, Issue Supplement 1, December 2020, Pages S81-S82
Background: Many genetic mutations affect aortic structure and function in mice, but little is known about the influence of background strain. We compared the biomechanical, structural, and gene expression responses of C57BL/6J and 129SvEv aortas to angiotensin II (AngII)-induced hypertension. Methods:...
Conference Abstract

P.55 Dietary Nitrate Prevents Progression of Carotid Subclinical Atherosclerosis Through BP-Independent Mechanisms in Patients with or at Risk of Type 2 Diabetes Mellitus: Results from the Double-Blind, Randomized-Controlled, Factorial Vasera Trial

Franca Morselli, Luca Faconti, Charlotte E Mills, Steve Morant, Philip J Chowienczyk, J Kennedy Cruickshank, Andrew J Webb, Alessandro Cavarape
Volume 26, Issue Supplement 1, December 2020, Pages S77-S77
Background: Epidemiological and animal studies suggest the potential of dietary nitrate (NO 3−) to inhibit atherogenesis. Spironolactone may improve arterial stiffness. We tested if 6 months’ intervention with dietary nitrate and spironolactone could affect carotid subclinical atherosclerosis and stiffness...
Conference Abstract

P.41 Measurement of Pressure-dependent Intra-Beat Changes in Carotid Pulse Wave Velocity using Image-Free Fast Ultrasound

Kiran V Raj, P M Nabeel, Jayaraj Joseph, Dinu Chandran, Mohanasankar Sivaprakasam
Volume 26, Issue Supplement 1, December 2020, Pages S63-S63
Background: The clinical significance of pressure-dependent intra-beat changes in local pulse-wave velocity (C) has recently come to light [1]. While reported methods require arterial pressure and diameter measurements from a single site to assess intra-beat changes in C, we present an image-free fast...
Conference Abstract

P.42 The Effects of Chemotherapy on Arterial Stiffness in Patients with Hodgkin Lymphoma

Constantinos Anagnostopoulos, Stavroula Giannouli, Nikolaos Ioakimidis, Paulos Kafouris, Iosif Koutagiar, Anastasia Sioni, Eirini Solomou, Dimitrios Terentes-Printzios, Dimitrios Tousoulis, Charalampos Vlachopoulos
Volume 26, Issue Supplement 1, December 2020, Pages S64-S64
Introduction: Malignancies and cardiovascular disease are the two leading causes of mortality worldwide [1]. While there is extensive literature describing the cardiotoxic effects of chemotherapy on left ventricular systolic function [2,3], there is only little evidence regarding chemotherapy effects...