P.66 Radial Artery Systolic-Diastolic Pulse Transit Time After Kidney Transplantation

Emy Philibert; Hasan Obeid; Mathilde Paré; Nadège Côté; Catherine Fortier; Rémi Goupil; Mohsen Agharazii

doi:10.2991/artres.k.201209.075

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Volume 26, Issue Supplement 1, December 2020, Pages S90 - S90

P.66 Radial Artery Systolic-Diastolic Pulse Transit Time After Kidney Transplantation

Authors

Emy Philibert¹^{, 2}^{, *}, Hasan Obeid¹^{, 2}^{, 4}^{, 5}, Mathilde Paré¹^{, 2}, Nadège Côté¹^{, 2}, Catherine Fortier¹^{, 2}^{, 4}^{, 5}, Rémi Goupil³, Mohsen Agharazii¹^{, 2}

¹CHU de Québec Research Center, L’Hôtel-Dieu de Québec Hospital

²Division of Nephrology, Faculty of Medicine, Université Laval

³Hôpital du Sacré-Cœur de Montréal

⁴INSERM U-970, Paris Cardiovascular research Center (PARCC)

⁵AP-HP, Pharmacology Unit, Hôpital Européen Georges Pompidou, Université de Paris

^*Corresponding author. Email: emy.philibert.1@ulaval.ca

Corresponding Author

Emy Philibert

Available Online 31 December 2020.

DOI: 10.2991/artres.k.201209.075 How to use a DOI?
Keywords: Kidney-transplantation; pulse-transit-time; radial-artery
Abstract: Purpose/Background/Objective: We have previously shown that restoration of kidney function through kidney transplantation (KTx) is associated with improved aortic stiffness. In this study, we aim to examine whether this change in aortic stiffness translates into improvement of radial artery systolic-diastolic pulse transit time.

Methods: Before and three months after KTx, we obtained radial pressure waveforms using applanation tonometry, in a group of 61 patients with restored renal function (eGFR > 45 ml/min/1,73 m²). Radial waveforms were recorded over a 10 seconds period and ensemble-averaged (using in house-MATLAB program) to obtain a single waveform and then modelled using two Gaussian functions, was then determined as the transit time between the first systolic peak T1 and the early diastolic peak T2.

Results: 61 patients (66% male, mean age: 48 ± 14 years, mean eGFR 3 months after Ktx: 66.0 ± 17.1) were assessed. After KTx, there was a significant reduction in central systolic (125,266 ± 21,848 to 108,994 ± 14,407, p < 0.001) and diastolic BP (84,718 11,679 to 74,092 9,774, p < 0.001), carotid-femoral PWV (11,444 2,626 to 10,235 1,890, p < 0.001) and carotid-radial PWV (9,350 1,485 to 8,831 1,291, p = 0,003). While T1 declined (0.184 [0.173–0.198] to 0.180 [0.168–0.194], p = 0.018), there were no significant changes in T2 (0.322 [0.295–0.360] to 0.318 [0.283–0.355], p = 0.169) and in dT1-2 (0.135 [0.119–0.161] to 0.134 [0.117–0.167], p = 0.457).

Conclusions: Contrary to our expectation, three months after KTx, we did not observe a significant change in radial systolic-diastolic pulse transit time after kidney transplantation, despite an improvement of BP, aortic and brachial stiffness.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: Artery Research
Volume-Issue: 26 - Supplement 1
Pages: S90 - S90
Publication Date: 2020/12/31
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.201209.075 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Emy Philibert
AU  - Hasan Obeid
AU  - Mathilde Paré
AU  - Nadège Côté
AU  - Catherine Fortier
AU  - Rémi Goupil
AU  - Mohsen Agharazii
PY  - 2020
DA  - 2020/12/31
TI  - P.66 Radial Artery Systolic-Diastolic Pulse Transit Time After Kidney Transplantation
JO  - Artery Research
SP  - S90
EP  - S90
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.075
DO  - 10.2991/artres.k.201209.075
ID  - Philibert2020
ER  -

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