Artery Research

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Volume 26, Issue Supplement 1, December 2020, Pages S84 - S84

P.61 Impact of Kidney Transplantation on Arterial Reservoir-Wave Analysis

Authors
Nadège Côté1, 2, *, Emy Philibert1, 2, Mathilde Paré1, 2, Rémi Goupil3, Catherine Fortier1, 2, 4, Martin G. Schultz5, James E. Sharman5, Mohsen Agharazii1, 2
1Division of Nephrology, Faculty of Medicine, Université Laval
2CHU de Québec Research Center, L’Hôtel-Dieu de Québec Hospital
3Hôpital du Sacré-Cœur de Montréal
4INSERM U-970, Paris Cardiovascular research Center (PARCC)
5Menzies Institute for Medical Research, University of Tasmania
*Corresponding author. Email: nadege.cote.1@ulaval.ca
Corresponding Author
Nadège Côté
Available Online 31 December 2020.
DOI
10.2991/artres.k.201209.070How to use a DOI?
Keywords
Kidney transplantation; reservoir-wave analysis
Abstract

Purpose/Background/Objective: According to reservoir-wave approach (RWA) arterial pressure is the sum of a reservoir pressure (RP) accounting for dynamic storage and release of blood from arteries, and an excess pressure (XSP) analogous to flow. RP is the minimal left ventricular work required to generate aortic flow, while XSP corresponds to surplus cardiac workload. We have previously shown that kidney transplantation (KTx) improves aortic stiffness [1], however, by adding renal vessels to existing vascular network, KTx may increase cardiac output. Thus, we aimed to examine whether XSP increases after KTx.

Methods: Before and 3 months after KTx, carotid pressure waves were recorded using arterial tonometry, calibrated using brachial diastolic and mean blood pressure. Using pressure only approach, reservoir-wave analysis was used to derive RP, XSP and their integrals (RPI, XSPI). RWA parameters were compared with Wilcoxon non-parametric test using SPSS 26.0.

Results: 75 patients (69% male, mean age 51 ± 13 years) were assessed. Three months after KTx, both carotid RP (121.2 ± 20.7 vs 103.5 ± 15.7, p < 0.001) and RPI (11192.52 ± 2763.11 vs 9531 ± 1978, p < 0.001) decreased significantly, but carotid XSP and XSPI remained unchanged. Carotid systolic (131.0 ± 23.2 vs 114.1 ± 15.5, p < 0.001) and diastolic (83.4 ± 11.9 vs 72.8 ± 9.93, p < 0.001) blood pressures were also reduced.

Conclusion: KTx decreased reservoir pressure, suggesting a decrease in minimal cardiac workload. However, we did not see an increase in excess pressure or its integral, suggesting that addition of a donor renal artery does not significantly alter cardiac outflow and excess workload 3 months after KTx.

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

REFERENCE

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Download article (PDF)
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Journal
Artery Research
Volume-Issue
26 - Supplement 1
Pages
S84 - S84
Publication Date
2020/12/31
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.201209.070How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Nadège Côté
AU  - Emy Philibert
AU  - Mathilde Paré
AU  - Rémi Goupil
AU  - Catherine Fortier
AU  - Martin G. Schultz
AU  - James E. Sharman
AU  - Mohsen Agharazii
PY  - 2020
DA  - 2020/12/31
TI  - P.61 Impact of Kidney Transplantation on Arterial Reservoir-Wave Analysis
JO  - Artery Research
SP  - S84
EP  - S84
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.070
DO  - 10.2991/artres.k.201209.070
ID  - Côté2020
ER  -