P.63 Sarcopenia and Atherosclerotic Occlusive Disease: How Much We Know and What We Need to Know About this Association?
- DOI
- 10.2991/artres.k.201209.072How to use a DOI?
- Keywords
- Sarcopenia; strength; atherosclerosis
- Abstract
Purpose/Background: Sarcopenia (decrease of muscle mass and function) has been linked with atherosclerosis [1]. The EWGSOP2 updated consensus, uses low muscle strength as the primary indicator of sarcopenia [2]. It is acknowledged that strength is better than mass for predicting adverse outcomes [2]. Handgrip strength (HGS) is a simple assessment to estimate overall muscular strength [3]. and is associated with cardiovascular mortality [4].
Objective: Analyze the relationship between HGS and atherosclerotic disease (carotid artery disease + lower extremity artery disease).
Methods: Prospective observation study was conducted from January to December 2019. The clinical and demographic data was recorded. Isometric HGS was measured with an adjustable handheld dynamometer (Jamar The higher value of each arm was used to classify the patient as sarcopenic or non-sarcopenic. Definition of sarcopenia: HGS <30 kgf in men and <20 kgf in women [5].
Results: 94 patients (aged 44–86 years) were analyzed: 64 sarcopenic and 30 non sarcopenic. Groups differed in the prevalence of diabetes and smoking status (Table 1). No differences were found in the carotid parameters analyzed (Table 1). There was, a difference in the prevalence of chronic limb-threatening ischemia (CLTI) in sarcopenic versus non-sarcopenic group (23.44% versus 6.67% p = 0.046). Importantly, binary logistic regression showed that diabetes (p = 0.014), and HGS (p = 0.027) have a significant effect on CLTI (Table 2).
Sarcopenia (n = 64) No Sarcopenia (n = 30) p Age (years) 69.81 ± 8.79 62.6 ± 8.61 p = 0.889 Male 47 (73.44%) 27 (90.00%) p = 0.067 Hypertension 51 (79.69%) 21 (70.00%) p = 0.301 Dyslipidemia 47 (73.43%) 18 (60.00%) p = 0.189 Smoking load (UMA) 24.42 ± 33.14 37.76 ± 31.8 p = 0.748 Smoker/Ex-smoker 33 (51.56%) 24 (80.00%) p = 0.013* Diabetes 28 (43.75%) 7 (23.33%) p = 0.049* Coronary disease 11 (17.19%) 4 (13.33%) p = 0.613 History of stroke 11 (17.19%) 3 (10.00%) p = 0.347 Total cholesterol (mg/dL) 158.16 ± 39.82 159.6 ± 30.72 p = 0.22 LEAD 43 (67.19%) 17 (56.67%) p = 0.275 Claudicants 28 (43.75%) 15 (50.00%) p = 0.615 CLTI 15 (23.44%) 2 (6.67%) p = 0.046* ABI right 0.83 ± 0.24 0.78 ± 0.29 p = 0.287 ABI left 0.81 ± 0.28 0.77 ± 0.23 p = 0.671 Right carotid artery stenosis 50–70 4 (6.25%) 2 (6.67%) p = 0.952 >70% 58 (90.63%) 27 (90.00%) p = 0.702 Light carotid artery stenosis 50–70 3 (4.79%) 1 (3.33%) p = 0.787 >70% 4 (6.25%) 2 (6.67%) p = 0.903 Area right carotid plaque (mm2) 21.22 ± 19.81 20.01 ± 17.04 p = 0.622 Average IMT- right (mm) 0.96 ± 0.41 0.88 ± 0.24 p = 0.159 Area left carotid plaque (mm2) 21.46 ± 18.73 21.47 ± 22.06 p = 0.948 Average IMT- left (mm) 0.93 ± 0.25 0.88 ± 0.29 p = 0.861 Independent variables Categories β 95% CI p CLTI Diabetes 1.488 1.34–14.60 0.014 Higher HGS −0.888 0.846–0.990 0.027 Conclusions: No relationship was found between sarcopenia (measured by HGS) and carotid atherosclerosis, differing from other authors [1,6]. In this study, sarcopenic had a higher incident of diabetes and CLTI. Sarcopenia and diabetes are reciprocally related and may share a similar pathogenetic pathway [7,8,9].
- Copyright
- © 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
REFERENCES
Cite this article
TY - JOUR AU - Joana Ferreira AU - Alexandre Carneiro AU - Pedro Cunha AU - Armando Mansilha AU - Isabel Vila AU - Cristina Cunha AU - Cristina Silva AU - Adhemar Longatto-Filho AU - Maria Correia-Neves AU - Gustavo Soutinho AU - Luís Meira-Machado AU - Amilcar Mesquita AU - Jorge Cotter PY - 2020 DA - 2020/12/31 TI - P.63 Sarcopenia and Atherosclerotic Occlusive Disease: How Much We Know and What We Need to Know About this Association? JO - Artery Research SP - S86 EP - S87 VL - 26 IS - Supplement 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.201209.072 DO - 10.2991/artres.k.201209.072 ID - Ferreira2020 ER -