Artery Research

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Volume 26, Issue Supplement 1, December 2020, Pages S92 - S92

P.68 WaveGraft–A Novel Endovascular Device Concept for Restoring the Natural Arterial Cushioning Effect

Authors
Florian Stefanov1, *, Dave Veerasingam2, Sarah Sayed1, Patrick Delassus1, Jonathan Bouchier-Hayes1, Liam Morris1
1Galway-Mayo Institute of Technology (GMIT)
2University Hospital Galway (UHG)
*Corresponding author. Email: florian.stefanov@gmit.ie
Corresponding Author
Florian Stefanov
Available Online 31 December 2020.
DOI
10.2991/artres.k.201209.077How to use a DOI?
Keywords
Pulsatile afterload; WaveGraft; perfusion
Abstract

Background and Objectives: The cushioning effect of large, healthy arteries reduces pulsatile afterload to the heart, reduces pulsatility in the microvasculature of target organs, and promotes coronary/cerebral perfusion [1]. With age, large arteries become stiffer, which increases both pulse wave velocity (PWV) and pulse pressure (PP). This results in isolated systolic hypertension [2], which is characterized by increased systolic blood pressure (SBP) with normal or low diastolic blood pressure (DBP) leading to left ventricular afterload. This study aims to replicate, experimentally, arterial stiffness of hypertensive patients, and proposes a novel thoracic endograft for restoring the arterial cushioning function.

Methods: The experimental setup comprised of two stiff descending aorta silicone replicas (DASR 1&2), pulse duplicator, heated blood mimicking fluid, pressure and flow sensors. An internal annular viscoelastic cushion, referred to as the ‘WaveGraft’, was deployed in DASR2. Firstly, pulsatile flow was directed through DASR1, (stiff vessel only), then it was diverted through DASR2 (vessel including WaveGraft).

Results: When compared to the stiff vessel replica (DASR1), the WaveGraft (DASR2) data showed significant reduction in PWV(−60%), SBP(−9%) and PP(−35%), while DBP increased by 10%. An increase in diastolic perfusion by up to 150%, was observed from the recorded data.

Conclusion: This work successfully replicated, key features of aortic hemodynamics in hypertension, linked to the increase in arterial stiffness. The WaveGraft concept showed great potential in altering blood pressure, flowrates and PWV, which may become an important clinical tool in the management of isolated systolic hypertension, heart failure, chronic kidney disease and other chronic conditions.

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

REFERENCES

<Previous Article In Issue
Download article (PDF)
Journal
Artery Research
Volume-Issue
26 - Supplement 1
Pages
S92 - S92
Publication Date
2020/12/31
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.201209.077How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Florian Stefanov
AU  - Dave Veerasingam
AU  - Sarah Sayed
AU  - Patrick Delassus
AU  - Jonathan Bouchier-Hayes
AU  - Liam Morris
PY  - 2020
DA  - 2020/12/31
TI  - P.68 WaveGraft–A Novel Endovascular Device Concept for Restoring the Natural Arterial Cushioning Effect
JO  - Artery Research
SP  - S92
EP  - S92
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.077
DO  - 10.2991/artres.k.201209.077
ID  - Stefanov2020
ER  -