Clinical Hematology International

Volume 2, Issue 4, December 2020
Review Article

1. Plasma Cell Leukemia – Facts and Controversies: More Questions than Answers?

Anna Suska, David H. Vesole, Jorge J. Castillo, Shaji K. Kumar, Hari Parameswaran, Maria V. Mateos, Thierry Facon, Alessandro Gozzetti, Gabor Mikala, Marta Szostek, Joseph Mikhael, Roman Hajek, Evangelos Terpos, Artur Jurczyszyn
Pages: 133 - 142
Plasma cell leukemia (PCL) is an aggressive hematological malignancy characterized by an uncontrolled clonal proliferation of plasma cells (PCs) in the bone marrow and peripheral blood. PCL has been defined by an absolute number of circulating PCs exceeding 2.0 × 109/L and/or >20% PCs in the total...
Review Article

2. What’s Important and New in Hemochromatosis?

Pierre Brissot, Eolia Brissot
Pages: 143 - 148
Major advances in the understanding of genetic iron overload have led to a clarification of the nosology and terminology of the related diseases. The term hemochromatosis should be reserved to the entities where iron overload is related to hepcidin deficiency or hepcidin resistance. The diagnosis of...
Review Article

3. CART Cell Toxicities: New Insight into Mechanisms and Management

Anas Zahid, Elizabeth L. Siegler, Saad S. Kenderian
Pages: 149 - 155
T cells genetically engineered with chimeric antigen receptors (CART) have become a potent class of cancer immunotherapeutics. Numerous clinical trials of CART cells have revealed remarkable remission rates in patients with relapsed or refractory hematologic malignancies. Despite recent clinical success,...
Research Article

4. Monocyte Reconstitution and Gut Microbiota Composition after Hematopoietic Stem Cell Transplantation

Sejal Morjaria, Allen W. Zhang, Sohn Kim, Jonathan U. Peled, Simone Becattini, Eric R. Littmann, Eric. G. Pamer, Michael C. Abt, Miguel-Angel Perales
Pages: 156 - 164
Background: Monocytes are an essential cellular component of the innate immune system that support the host’s effectiveness to combat a range of infectious pathogens. Hemopoietic cell transplantation (HCT) results in transient monocyte depletion, but the factors that regulate recovery of monocyte populations...
Research Article

5. Emicizumab Associated Rhabdomyolysis in Hemophilia A

Joseph A. Wilson, Stephanie Hayden, Alexander Asamoah, Vivek R. Sharma, David C. Jennings, Ashok B. Raj
Pages: 165 - 167
Emicizumab is increasingly the front-line treatment for patients with Hemophilia A with or without inhibitors. Rhabdomyolysis is a syndrome of muscle necrosis and release of intracellular muscle constituents into the circulation. Creatine kinase (CK) levels are typically markedly elevated, and muscle...

6. The Incidence and Timing of Blood Cultures in Multiple Myeloma – Results from a Retrospective, Single Center, Real-World Study

Agoston Gyula Szabo, Katrine Fladeland Iversen, Flemming Schønning Rosenvinge, Sören Möller, Torben Plesner
Pages: 168 - 172

7. COVID-19 in Hematologic Malignancies: Big Challenges

Yongxian Hu, Linqin Wang, Qu Cui, Elaine Tan Su Yin, Hengwei Wu, Arnon Nagler, He Huang
Pages: 173 - 175