Clinical Hematology International

Volume 3, Issue 1, March 2021
Review Article

2. The Many Faces of Cytokine Release Syndrome-Related Coagulopathy

Jiasheng Wang, John Doran
Pages: 3 - 12
Cytokine release syndrome (CRS) has been increasingly recognized in various conditions including the coronavirus disease 2019 (COVID-19). It is not only associated with systemic inflammatory symptoms, but also hematological complications such as coagulopathy. CRS can affect various components of the...
Review Article

3. Machine Learning Applications in the Diagnosis of Benign and Malignant Hematological Diseases

Ibrahim N. Muhsen, David Shyr, Anthony D. Sung, Shahrukh K. Hashmi
Pages: 13 - 20
The use of machine learning (ML) and deep learning (DL) methods in hematology includes diagnostic, prognostic, and therapeutic applications. This increase is due to the improved access to ML and DL tools and the expansion of medical data. The utilization of ML remains limited in clinical practice, with...
Review Article

4. Polatuzumab Vedotin: Current Role and Future Applications in the Treatment of Patients with Diffuse Large B-Cell Lymphoma

Rita Assi, Nohad Masri, Iman Abou Dalle, Jean El-Cheikh, Hady Ghanem, Ali Bazarbachi
Pages: 21 - 26
Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous disease. Despite good responses to standard of care frontline chemoimmunotherapy, the prognosis of relapsed/refractory (R/R) patients remains obscured by the possible inadequate responses to salvage therapy, eligibility...
Research Article

5. How to Simplify the Evaluation of Newly Introduced Chemotherapeutic Interventions in Myeloma

Treen Carson Michael Morris, Mary B. Drake, Paul J. Kettle, Tracey McGuigan, Maeve Leahy, Michael O’Dwyer, Helen Enright, Tanya O’Shea, Rakesh Popat, Heather E. Oakervee, Kwee Yong, Jamie D. Cavenagh, David A. Cairns, Alberto Alvarez-Iglesias, Gordon Cook
Pages: 27 - 33
When the bortezomib [PS341], adriamycin and dexamethasone (PAD) regimen was first evaluated, the response rate in untreated patients was much superior to that elicited by conventional chemotherapeutic agents. We demonstrated the efficacy of PAD in relapsed or refractory patients by comparing the response...
Research Article

6. Association of Patient-Reported Physical Activity on Allogeneic Hematopoietic Cell Transplant Outcomes

Reena V. Jayani, Joseph Pidala, Heather Jim, Junmin Whiting, Qianxing Mo, Asmita Mishra
Pages: 34 - 39
Background: Physical function prior to allogeneic hematopoietic cell transplant (HCT) is associated with survival and may be associated with patient physical activity (PA). Tools to evaluate PA prior to HCT are scarce. We aimed to evaluate the impact of easily obtained patient-report of PA prior to HCT...