Association of Patient-Reported Physical Activity on Allogeneic Hematopoietic Cell Transplant Outcomes
- https://doi.org/10.2991/chi.k.210221.001How to use a DOI?
- Allogeneic hematopoietic cell transplant; physical activity; stem cell transplantation
Background: Physical function prior to allogeneic hematopoietic cell transplant (HCT) is associated with survival and may be associated with patient physical activity (PA). Tools to evaluate PA prior to HCT are scarce. We aimed to evaluate the impact of easily obtained patient-report of PA prior to HCT on survival.
Methods: HCT recipients between January 1, 2011 and July 5, 2018 and who completed an International Physical Activity Questionnaire Short Form were included. This patient survey captures self-reported activities over the preceding week to determine PA level.
Results: We report a retrospective study of 587 adult (age ≥18) HCT recipients. The median age for the cohort was 57.9 years (range 19.9–76.1) with 149 patients (25.4%) age ≥65. Younger patients reported higher PA (low, median age 59.7 years; moderate, 56.1; high, 55.7; p < 0.001). High activity level was reported by males (66.7%; p < 0.001). Patients with low PA had HCT-comorbidity index (HCT-CI) ≥ 3 (68.1%, p = 0.002). When controlling for HCT-CI and disease risk index, higher PA was associated with improved overall survival (HR 0.954, 95% CI 0.921–0.988, p = 0.009). After adjusting for HCT-CI, higher PA was associated with reduced non-relapse mortality (NRM) (HR 0.931, 95% CI 0.891–0.972, p = 0.0013). Subgroup analysis in adults age ≥65 years also found that PA was lower in this population and associated with NRM mortality (HR 0.95, 95% CI 0.90–0.99, p = 0.041).
Conclusion: Patient-reported PA is a predictor of post-HCT survival. Future studies to validate incorporation of self-report tools to better predict patient-related adverse risk are warranted.
- © 2021 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Reena V. Jayani AU - Joseph Pidala AU - Heather Jim AU - Junmin Whiting AU - Qianxing Mo AU - Asmita Mishra PY - 2021 DA - 2021/03/04 TI - Association of Patient-Reported Physical Activity on Allogeneic Hematopoietic Cell Transplant Outcomes JO - Clinical Hematology International SP - 34 EP - 39 VL - 3 IS - 1 SN - 2590-0048 UR - https://doi.org/10.2991/chi.k.210221.001 DO - https://doi.org/10.2991/chi.k.210221.001 ID - Jayani2021 ER -