Association of Patient-Reported Physical Activity on Allogeneic Hematopoietic Cell Transplant Outcomes

Authors

Reena V. Jayani^{1, 2, *,} , Joseph Pidala¹, Heather Jim^3, , Junmin Whiting⁴, Qianxing Mo⁴, Asmita Mishra¹

¹Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, 12902 USF Magnolia Dr, Tampa, FL 33612, USA

²Department of Medicine, Vanderbilt University Medical Center, 2220 Pierce Ave, 777 Preston Research Building, Nashville, TN 37232-6307, USA

³Department of Health Outcomes and Behavior, Moffitt Cancer Center, 12902 USF Magnolia Dr, Tampa, FL 33612, USA

⁴Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, 12902 USF Magnolia Dr, Tampa, FL 33612, USA

^*Corresponding author. Email: Reena.V.Jayani@vumc.org

DOI

10.2991/chi.k.210221.001How to use a DOI?

Keywords

Allogeneic hematopoietic cell transplant; physical activity; stem cell transplantation

Abstract

Background: Physical function prior to allogeneic hematopoietic cell transplant (HCT) is associated with survival and may be associated with patient physical activity (PA). Tools to evaluate PA prior to HCT are scarce. We aimed to evaluate the impact of easily obtained patient-report of PA prior to HCT on survival.

Methods: HCT recipients between January 1, 2011 and July 5, 2018 and who completed an International Physical Activity Questionnaire Short Form were included. This patient survey captures self-reported activities over the preceding week to determine PA level.

Results: We report a retrospective study of 587 adult (age ≥18) HCT recipients. The median age for the cohort was 57.9 years (range 19.9–76.1) with 149 patients (25.4%) age ≥65. Younger patients reported higher PA (low, median age 59.7 years; moderate, 56.1; high, 55.7; p < 0.001). High activity level was reported by males (66.7%; p < 0.001). Patients with low PA had HCT-comorbidity index (HCT-CI) ≥ 3 (68.1%, p = 0.002). When controlling for HCT-CI and disease risk index, higher PA was associated with improved overall survival (HR 0.954, 95% CI 0.921–0.988, p = 0.009). After adjusting for HCT-CI, higher PA was associated with reduced non-relapse mortality (NRM) (HR 0.931, 95% CI 0.891–0.972, p = 0.0013). Subgroup analysis in adults age ≥65 years also found that PA was lower in this population and associated with NRM mortality (HR 0.95, 95% CI 0.90–0.99, p = 0.041).

Conclusion: Patient-reported PA is a predictor of post-HCT survival. Future studies to validate incorporation of self-report tools to better predict patient-related adverse risk are warranted.

Copyright

© 2021 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Reena V. Jayani
AU  - Joseph Pidala
AU  - Heather Jim
AU  - Junmin Whiting
AU  - Qianxing Mo
AU  - Asmita Mishra
PY  - 2021
DA  - 2021/03/04
TI  - Association of Patient-Reported Physical Activity on Allogeneic Hematopoietic Cell Transplant Outcomes
JO  - Clinical Hematology International
SP  - 34
EP  - 39
VL  - 3
IS  - 1
SN  - 2590-0048
UR  - https://doi.org/10.2991/chi.k.210221.001
DO  - 10.2991/chi.k.210221.001
ID  - Jayani2021
ER  -