Clinical Hematology International

Volume 3, Issue 1, March 2021, Pages 34 - 39

Association of Patient-Reported Physical Activity on Allogeneic Hematopoietic Cell Transplant Outcomes

Authors
Reena V. Jayani1, 2, *, ORCID, Joseph Pidala1, Heather Jim3, ORCID, Junmin Whiting4, Qianxing Mo4, Asmita Mishra1
1Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, 12902 USF Magnolia Dr, Tampa, FL 33612, USA
2Department of Medicine, Vanderbilt University Medical Center, 2220 Pierce Ave, 777 Preston Research Building, Nashville, TN 37232-6307, USA
3Department of Health Outcomes and Behavior, Moffitt Cancer Center, 12902 USF Magnolia Dr, Tampa, FL 33612, USA
4Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, 12902 USF Magnolia Dr, Tampa, FL 33612, USA
*Corresponding author. Email: Reena.V.Jayani@vumc.org
Corresponding Author
Reena V. Jayani
Received 31 December 2020, Accepted 15 February 2021, Available Online 4 March 2021.
DOI
https://doi.org/10.2991/chi.k.210221.001How to use a DOI?
Keywords
Allogeneic hematopoietic cell transplant; physical activity; stem cell transplantation
Abstract

Background: Physical function prior to allogeneic hematopoietic cell transplant (HCT) is associated with survival and may be associated with patient physical activity (PA). Tools to evaluate PA prior to HCT are scarce. We aimed to evaluate the impact of easily obtained patient-report of PA prior to HCT on survival.

Methods: HCT recipients between January 1, 2011 and July 5, 2018 and who completed an International Physical Activity Questionnaire Short Form were included. This patient survey captures self-reported activities over the preceding week to determine PA level.

Results: We report a retrospective study of 587 adult (age ≥18) HCT recipients. The median age for the cohort was 57.9 years (range 19.9–76.1) with 149 patients (25.4%) age ≥65. Younger patients reported higher PA (low, median age 59.7 years; moderate, 56.1; high, 55.7; p < 0.001). High activity level was reported by males (66.7%; p < 0.001). Patients with low PA had HCT-comorbidity index (HCT-CI) ≥ 3 (68.1%, p = 0.002). When controlling for HCT-CI and disease risk index, higher PA was associated with improved overall survival (HR 0.954, 95% CI 0.921–0.988, p = 0.009). After adjusting for HCT-CI, higher PA was associated with reduced non-relapse mortality (NRM) (HR 0.931, 95% CI 0.891–0.972, p = 0.0013). Subgroup analysis in adults age ≥65 years also found that PA was lower in this population and associated with NRM mortality (HR 0.95, 95% CI 0.90–0.99, p = 0.041).

Conclusion: Patient-reported PA is a predictor of post-HCT survival. Future studies to validate incorporation of self-report tools to better predict patient-related adverse risk are warranted.

Copyright
© 2021 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)
View full text (HTML)

Journal
Clinical Hematology International
Volume-Issue
3 - 1
Pages
34 - 39
Publication Date
2021/03/04
ISSN (Online)
2590-0048
DOI
https://doi.org/10.2991/chi.k.210221.001How to use a DOI?
Copyright
© 2021 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Reena V. Jayani
AU  - Joseph Pidala
AU  - Heather Jim
AU  - Junmin Whiting
AU  - Qianxing Mo
AU  - Asmita Mishra
PY  - 2021
DA  - 2021/03/04
TI  - Association of Patient-Reported Physical Activity on Allogeneic Hematopoietic Cell Transplant Outcomes
JO  - Clinical Hematology International
SP  - 34
EP  - 39
VL  - 3
IS  - 1
SN  - 2590-0048
UR  - https://doi.org/10.2991/chi.k.210221.001
DO  - https://doi.org/10.2991/chi.k.210221.001
ID  - Jayani2021
ER  -