Difference in cerebral blood flow velocity in neonates with and without hyperbilirubinemia

Sriparna Basu; Dibyajyoti De; Ram Chandra Shukla; Ashok Kumar

doi:10.1016/j.jegh.2013.09.008

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Volume 4, Issue 2, June 2014, Pages 97 - 106

Difference in cerebral blood flow velocity in neonates with and without hyperbilirubinemia

Authors

Sriparna Basu^a^{, *}^,drsriparnabasu@rediffmail.com, Dibyajyoti De^a, Ram Chandra Shukla^b, Ashok Kumar^a

^aDepartment of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India

^bDepartment of Radiodiagnosis, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India

^*Corresponding author. Tel.: +91 9935340260; fax: +91 542 2367568.

Corresponding Author

Sriparna Basudrsriparnabasu@rediffmail.com

Received 2 June 2013, Revised 27 September 2013, Accepted 27 September 2013, Available Online 31 October 2013.

DOI: 10.1016/j.jegh.2013.09.008 How to use a DOI?
Keywords: Cerebral blood flow velocity; Neonate; Phototherapy; Transcranial color Doppler ultrasound; Unconjugated hyperbilirubinemia
Abstract: Purpose: To evaluate the difference in cerebral blood flow velocity (CBFV) in neonates with and without hyperbilirubinemia.

Methods: CBFV of 70 healthy late-preterm and term newborns with unconjugated hyperbilirubinemia (UCH) reaching the threshold of phototherapy requirement was compared with 70 gestational- and postnatal age-matched controls without hyperbilirubinemia. Resistance index (RI), pulsatility index (PI), peak systolic velocity (PSV) and vascular diameter were measured in internal carotid, vertebral and middle cerebral arteries by transcranial color Doppler ultrasound at the beginning of phototherapy, after 48–72 h of starting phototherapy and at 5–7 days after its stoppage. In controls CBFV was assessed once at inclusion.

Results: Both the groups were comparable. An increase in CBFV (decreased RI and PI, increased PSV and vasodilation) was observed in the UCH group. A further increase in CBFV was noticed after 48 h of phototherapy. After 5–7 days of stoppage of phototherapy, though there was a significant reduction in CBFV in mild-to-moderate UCH (serum bilirubin ⩽25 mg/dL), in severe UCH (serum bilirubin >25 mg/dL), CBFV remained increased. Four neonates developed features of acute bilirubin encephalopathy and had significantly higher CBFV compared to those with normal outcome.

Conclusions: An increase in CBFV was observed in neonates with UCH compared to those without hyperbilirubinemia.
Copyright: © 2013 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd.
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Journal: Journal of Epidemiology and Global Health
Volume-Issue: 4 - 2
Pages: 97 - 106
Publication Date: 2013/10/31
ISSN (Online): 2210-6014
ISSN (Print): 2210-6006
DOI: 10.1016/j.jegh.2013.09.008 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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ris enw bib

TY  - JOUR
AU  - Sriparna Basu
AU  - Dibyajyoti De
AU  - Ram Chandra Shukla
AU  - Ashok Kumar
PY  - 2013
DA  - 2013/10/31
TI  - Difference in cerebral blood flow velocity in neonates with and without hyperbilirubinemia
JO  - Journal of Epidemiology and Global Health
SP  - 97
EP  - 106
VL  - 4
IS  - 2
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2013.09.008
DO  - 10.1016/j.jegh.2013.09.008
ID  - Basu2013
ER  -

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