The Association between Homocysteine, Arterial Stiffness and Executive Function Middle-age and Older Women
Department of Physical Therapy, Faculty of Medical and Health Sciences, Tsukuba International University, 6-8-33, Manabe, Tsuchiura, Ibaraki, Japan
Department of Sports Research, Japan Institute of Sport Sciences, 3-15-1 Nishigaoka, Kitaku, Tokyo, Japan
- https://doi.org/10.2991/artres.k.201102.003How to use a DOI?
- Plasma homocysteine, arterial stiffness, executive function
Age-related decreases in executive function and an increase in arterial stiffness and plasma homocysteine levels are related to the risk of dementia. However, the association between executive function, arterial stiffness, and homocysteine levels remains unclear. This study aimed to investigate the relationship between executive function, arterial stiffness, and plasma homocysteine in 82 middle-aged and older women. The Stroop interference time, Brachial-ankle Pulse Wave Velocity (baPWV), and plasma homocysteine concentration were collected. The correlation analyses revealed that the Stroop interference time was significantly correlated with plasma homocysteine (r = 0.40, p < 0.001) and baPWV (r = 0.38, p = 0.001). In addition, plasma homocysteine levels were significantly correlated with baPWV (r = 0.48, p < 0.001). In the mediated analyses, the plasma homocysteine level directly (β = 0.24; p = 0.037) and indirectly (β = 0.12, 95% confidence interval [0.007, 0.238]) affected the Stroop interference time. These results suggest that higher plasma homocysteine levels are associated with a decline in executive function mediated by higher artery stiffness in middle-aged and older women.
- © 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Ai Shindo-Hamasaki AU - Nobuhiko Akazawa AU - Reiko Momma AU - Seiji Maeda PY - 2020 DA - 2020/11 TI - The Association between Homocysteine, Arterial Stiffness and Executive Function Middle-age and Older Women JO - Artery Research SP - 32 EP - 37 VL - 27 IS - 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.201102.003 DO - https://doi.org/10.2991/artres.k.201102.003 ID - Shindo-Hamasaki2020 ER -