Part of Springer Nature

Artery Research

Volume 27, Issue 1, March 2021, Pages 32 - 37

The Association between Homocysteine, Arterial Stiffness and Executive Function Middle-age and Older Women

Authors
Ai Shindo-Hamasaki, Nobuhiko Akazawa, Reiko Momma, Seiji Maeda*, ORCID
Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Ibaraki, Japan

Present address:

Department of Physical Therapy, Faculty of Medical and Health Sciences, Tsukuba International University, 6-8-33, Manabe, Tsuchiura, Ibaraki, Japan

Department of Sports Research, Japan Institute of Sport Sciences, 3-15-1 Nishigaoka, Kitaku, Tokyo, Japan

*Corresponding author. Email: maeda.seiji.gn@u.tsukuba.ac.jp
Corresponding Author
Seiji Maeda
Received 3 June 2020, Accepted 24 October 2020, Available Online 13 November 2020.
DOI
https://doi.org/10.2991/artres.k.201102.003How to use a DOI?
Keywords
Plasma homocysteine, arterial stiffness, executive function
Abstract

Age-related decreases in executive function and an increase in arterial stiffness and plasma homocysteine levels are related to the risk of dementia. However, the association between executive function, arterial stiffness, and homocysteine levels remains unclear. This study aimed to investigate the relationship between executive function, arterial stiffness, and plasma homocysteine in 82 middle-aged and older women. The Stroop interference time, Brachial-ankle Pulse Wave Velocity (baPWV), and plasma homocysteine concentration were collected. The correlation analyses revealed that the Stroop interference time was significantly correlated with plasma homocysteine (r = 0.40, p < 0.001) and baPWV (r = 0.38, p = 0.001). In addition, plasma homocysteine levels were significantly correlated with baPWV (r = 0.48, p < 0.001). In the mediated analyses, the plasma homocysteine level directly (β = 0.24; p = 0.037) and indirectly (β = 0.12, 95% confidence interval [0.007, 0.238]) affected the Stroop interference time. These results suggest that higher plasma homocysteine levels are associated with a decline in executive function mediated by higher artery stiffness in middle-aged and older women.

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
27 - 1
Pages
32 - 37
Publication Date
2020/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.2991/artres.k.201102.003How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Ai Shindo-Hamasaki
AU  - Nobuhiko Akazawa
AU  - Reiko Momma
AU  - Seiji Maeda
PY  - 2020
DA  - 2020/11
TI  - The Association between Homocysteine, Arterial Stiffness and Executive Function Middle-age and Older Women
JO  - Artery Research
SP  - 32
EP  - 37
VL  - 27
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201102.003
DO  - https://doi.org/10.2991/artres.k.201102.003
ID  - Shindo-Hamasaki2020
ER  -