The Association between Homocysteine, Arterial Stiffness and Executive Function Middle-age and Older Women

Authors

Ai Shindo-Hamasaki^†, Nobuhiko Akazawa^‡, Reiko Momma, Seiji Maeda^*,

Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Ibaraki, Japan

Present address:

^†

Department of Physical Therapy, Faculty of Medical and Health Sciences, Tsukuba International University, 6-8-33, Manabe, Tsuchiura, Ibaraki, Japan

^‡

Department of Sports Research, Japan Institute of Sport Sciences, 3-15-1 Nishigaoka, Kitaku, Tokyo, Japan

^*Corresponding author. Email: maeda.seiji.gn@u.tsukuba.ac.jp

DOI

10.2991/artres.k.201102.003How to use a DOI?

Keywords

Plasma homocysteine; arterial stiffness; executive function

Abstract

Age-related decreases in executive function and an increase in arterial stiffness and plasma homocysteine levels are related to the risk of dementia. However, the association between executive function, arterial stiffness, and homocysteine levels remains unclear. This study aimed to investigate the relationship between executive function, arterial stiffness, and plasma homocysteine in 82 middle-aged and older women. The Stroop interference time, Brachial-ankle Pulse Wave Velocity (baPWV), and plasma homocysteine concentration were collected. The correlation analyses revealed that the Stroop interference time was significantly correlated with plasma homocysteine (r = 0.40, p < 0.001) and baPWV (r = 0.38, p = 0.001). In addition, plasma homocysteine levels were significantly correlated with baPWV (r = 0.48, p < 0.001). In the mediated analyses, the plasma homocysteine level directly (β = 0.24; p = 0.037) and indirectly (β = 0.12, 95% confidence interval [0.007, 0.238]) affected the Stroop interference time. These results suggest that higher plasma homocysteine levels are associated with a decline in executive function mediated by higher artery stiffness in middle-aged and older women.

Copyright

© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Ai Shindo-Hamasaki
AU  - Nobuhiko Akazawa
AU  - Reiko Momma
AU  - Seiji Maeda
PY  - 2020
DA  - 2020/11/13
TI  - The Association between Homocysteine, Arterial Stiffness and Executive Function Middle-age and Older Women
JO  - Artery Research
SP  - 32
EP  - 37
VL  - 27
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201102.003
DO  - 10.2991/artres.k.201102.003
ID  - Shindo-Hamasaki2020
ER  -