MicroRNAs associated with the pathways involved in the pathogenesis of abdominal aortic aneurysms

P.W. Stather; J.B. Wild; N. Sylvius; E. Choke; R.D. Sayers; M.J. Bown

doi:10.1016/j.artres.2012.09.005

<Previous Article In Issue

Next Article In Issue>

Volume 7, Issue 1, March 2013, Pages 28 - 35

MicroRNAs associated with the pathways involved in the pathogenesis of abdominal aortic aneurysms

Authors

P.W. Stather^a^{, *}, J.B. Wild^a, N. Sylvius^b, E. Choke^c, R.D. Sayers^c, M.J. Bown^c

^aVascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester LE2 7LX, UK

^bGenomics Facility, University of Leicester, Leicester LE2 7LX, UK

^cLeicester Cardiovascular Biomedical Research Unit, UK

^*Corresponding author. Tel.: +44 07748964286. E-mail addresses: philstather@doctors.org.uk, pws7@le.ac.uk (P.W. Stather).

Corresponding Author

P.W. Stather

Received 22 February 2012, Revised 21 June 2012, Accepted 17 September 2012, Available Online 11 October 2012.

DOI: 10.1016/j.artres.2012.09.005 How to use a DOI?
Keywords: MicroRNA; miRNA; Aneurysm; Vascular smooth muscle cell; Extracellular matrix
Abstract: Objectives: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at a post-transcriptional level. Through binding to mRNA sequences, miRNAs have a wide variety of functions, and are key regulators in vascular disease. Although there are only 2 papers looking directly at the association between miRNA and abdominal aortic aneurysms (AAA), several studies have looked at miRNAs implicated in vascular smooth muscle cell (VSMC) proliferation, extracellular matrix (ECM) remodelling, and the known genes and genetic loci associated with AAA. This review aims to determine potential miRNAs associated with the pathways involved in abdominal aortic aneurysm (AAA) pathophysiology, to guide future focused research.

Methods and results: A systematic review of the published literature was performed, searching for articles detailing miRNA associations with AAA or processes associated with aneurysm formation. Eighteen miRNAs were identified to be associated with aneurysm formation, ten miRNAs were associated with VSMC physiology, and nine miRNAs were involved in regulation of the ECM. Seven miRNAs were replicated in more than 1 study (miR-19b, miR-21, miR-26a, miR-29b, miR-146a, miR-221, miR-222).

Conclusions: The association between miRNAs associated with known AAA genes, and those involved in VSMC/ECM pathophysiology highlight promising areas for further significantly powered human studies, which with miRNA level modulation, present a novel opportunity to determine pathways for AAA formation.
Open Access: This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

<Previous Article In Issue

Next Article In Issue>

Journal: Artery Research
Volume-Issue: 7 - 1
Pages: 28 - 35
Publication Date: 2012/10/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2012.09.005 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - P.W. Stather
AU  - J.B. Wild
AU  - N. Sylvius
AU  - E. Choke
AU  - R.D. Sayers
AU  - M.J. Bown
PY  - 2012
DA  - 2012/10/11
TI  - MicroRNAs associated with the pathways involved in the pathogenesis of abdominal aortic aneurysms
JO  - Artery Research
SP  - 28
EP  - 35
VL  - 7
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.005
DO  - 10.1016/j.artres.2012.09.005
ID  - Stather2012
ER  -

download .riscopy to clipboard