Artery Research

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Volume 7, Issue 1, March 2013, Pages 36 - 41

Vascular compliance during insulin infusion and oral glucose challenge

Authors
Houry Puzantiana, *, Ari Mosenkisb, Raymond R. Townsendb
aDepartment of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Claire Fagin Hall, 418 Curie Blvd., Philadelphia, PA 19104, USA
bRenal, Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Suite 1-300S, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA
*Corresponding author. Tel.: +1 215 5732391; fax: +1 215 5737507. E-mail addresses: hourypuz@nursing.upenn.edu (H. Puzantian), ckhcam@gmail.com (A. Mosenkis), townsend@exchange.upenn.edu (R. R. Townsend).
Corresponding Author
Houry Puzantian
Received 3 October 2012, Revised 21 December 2012, Accepted 2 January 2013, Available Online 24 January 2013.
DOI
10.1016/j.artres.2013.01.001How to use a DOI?
Keywords
Pulse wave velocity; Arterial stiffness; Insulin
Abstract

Background: Vascular stiffness predicts cardiovascular disease (CVD). Pulse wave velocity (PWV), reflecting vascular stiffness, though determined largely by mean arterial pressure; is also sensitive to insulin and glucose. Capacitance in small (C2) and large vessels (C1), reflecting vascular responsiveness to hemodynamic challenges, may also be influenced by insulin and glucose. The purpose of this study was to test the effects of insulin and glucose on arterial function in healthy individuals.

Methods: Excluding people with BMI >27.5 kg/m2, diabetes, impaired glucose tolerance, hypotension or hypertension, 14 adults were enrolled. Subjects underwent randomly either a 2 h euglycemic clamping, or a 2-h OGTT first, with the other procedure performed up to one month later. Pulse wave velocity (PWV) and vascular compliance were measured by tonometry.

Results: The sample (n = 14) included 10 Caucasians, 8 males, mean age = 28 ± 8 years, BMI = 24 ± 2 kg/m2, SBP = 113 ± 9 mmHg, DBP = 70 ± 6 mmHg, and glucose = 73 ± 11 mg/dl. There was a significant increase in mean PWV between 30 and 120 min (p = 0.049), during the euglycemic clamp. PWV change during OGTT was not significant.

Conclusion: PWV increased during euglycemic clamp conditions without significant changes in C1 or C2. Oral glucose had less effect on PWV and changes in C1 and C2 were minimal. These data support mechanisms that link insulin and arterial stiffness in vascular physiology and suggest that part of the mechanism of CVD in insulin resistance may relate to insulin’s effects on arterial stiffness.

Copyright
© 2013 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
7 - 1
Pages
36 - 41
Publication Date
2013/01/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.01.001How to use a DOI?
Copyright
© 2013 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Houry Puzantian
AU  - Ari Mosenkis
AU  - Raymond R. Townsend
PY  - 2013
DA  - 2013/01/24
TI  - Vascular compliance during insulin infusion and oral glucose challenge
JO  - Artery Research
SP  - 36
EP  - 41
VL  - 7
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.01.001
DO  - 10.1016/j.artres.2013.01.001
ID  - Puzantian2013
ER  -