Epidemiology of invasive pneumococcal disease in Saudi Arabian children younger than 5 years of age

Yagob Almazrou; Atef M. Shibl; Riyadh Alkhlaif; Jean-Yves Pirçon; Sameh Anis; Walid Kandeil; William P. Hausdorff

doi:10.1016/j.jegh.2015.08.002

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Volume 6, Issue 2, June 2016, Pages 95 - 104

Epidemiology of invasive pneumococcal disease in Saudi Arabian children younger than 5 years of age

Authors

Yagob Almazrou^a, Atef M. Shibl^b^{, *}^,ashibl@alfaisal.edu amshibl1@yahoo.com, Riyadh Alkhlaif^a, Jean-Yves Pirçon^c, Sameh Anis^c, Walid Kandeil^c, William P. Hausdorff^c

^aMinistry of Health, Riyadh, Saudi Arabia

^bCollege of Medicine, Al Faisal University, PO Box 50927, Riyadh 11533, Saudi Arabia

^cGSK Vaccines, Wavre, Belgium

^*Corresponding author. Tel.: +966 505 302 775 (mobile).

Corresponding Author

Atef M. Shiblashibl@alfaisal.edu amshibl1@yahoo.com

Received 24 February 2015, Revised 13 August 2015, Accepted 20 August 2015, Available Online 11 September 2015.

DOI: 10.1016/j.jegh.2015.08.002 How to use a DOI?
Keywords: Child; Invasive pneumococcal disease; Multi-drug resistance; Saudi Arabia; Serotype; Streptococcus pneumoniae
Abstract: This study evaluated the incidence, serotype distribution, and antimicrobial susceptibility of invasive pneumococcal disease (IPD) in Saudi Arabian children. This multicenter, prospective, clinical surveillance study included children under 5 years of age, residents of one of the seven study health areas, who were brought to a study hospital with suspicion of IPD. Bacterial isolates from sterile site samples, collected less than 24 h after hospital visit/admission, were identified, serotyped, and tested for antibiotic susceptibility. Between June 2007 and January 2009, 631 episodes of suspected IPD were recorded, and 623 were included in the analysis. One child (0.2%) had previously received one dose of a pneumococcal vaccine. Forty-seven episodes were positive for Streptococcus pneumoniae and three for Haemophilus influenzae. The incidence of confirmed IPD cases was estimated to be 2.5–21.6 per 100,000 children (<5 years). Among the 46 S. pneumoniae isolates serotyped and tested for antibiotic susceptibility, the most common serotypes were 5 and 23F (20% each), 6B (17%), and 1 and 14 (11% each). Sixty-three percent of isolates were multidrug-resistant. Vaccination of Saudi Arabian children with expanded-coverage conjugate pneumococcal vaccines containing serotypes 1 and 5 could have a substantial impact to prevent IPD in this population.
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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Journal: Journal of Epidemiology and Global Health
Volume-Issue: 6 - 2
Pages: 95 - 104
Publication Date: 2015/09/11
ISSN (Online): 2210-6014
ISSN (Print): 2210-6006
DOI: 10.1016/j.jegh.2015.08.002 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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ris enw bib

TY  - JOUR
AU  - Yagob Almazrou
AU  - Atef M. Shibl
AU  - Riyadh Alkhlaif
AU  - Jean-Yves Pirçon
AU  - Sameh Anis
AU  - Walid Kandeil
AU  - William P. Hausdorff
PY  - 2015
DA  - 2015/09/11
TI  - Epidemiology of invasive pneumococcal disease in Saudi Arabian children younger than 5 years of age
JO  - Journal of Epidemiology and Global Health
SP  - 95
EP  - 104
VL  - 6
IS  - 2
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2015.08.002
DO  - 10.1016/j.jegh.2015.08.002
ID  - Almazrou2015
ER  -

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