eFood

In Press, Uncorrected Proof, Available Online: 22 May 2020

The Anticancer Activity and Mechanisms of Ginsenosides: An Updated Review

Authors
Hongwei Chen1, 2, 3, Haixia Yang4, Daidi Fan1, 2, 3, Jianjun Deng1, 2, 3, *
1Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi’an 710069, China
2Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi’an 710069, China
3Biotech & Biomed Research Institute, Northwest University, 229 North Taibai Road, Xi’an 710069, China
4Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
*Corresponding author. Email: dengjianjun@nwu.edu.cn
Corresponding Author
Jianjun Deng
Received 7 April 2020, Accepted 11 May 2020, Available Online 22 May 2020.
DOI
https://doi.org/10.2991/efood.k.200512.001How to use a DOI?
Keywords
Ginseng, ginsenosides, biological activity, cancer therapy, mechanism
Abstract

The annual global mortality rate of cancer has increased dramatically. Although various therapies are used for cancer, the results have not been satisfactory. Chemotherapy is currently the most common treatment option. However, serious side effects and drug resistance impede the therapeutic efficacy of chemotherapeutic drugs. Increasing evidence has shown that ginsenosides as a type of phytochemicals play an important role in the prevention and treatment of cancers, such as colon cancer, cervical cancer, ovarian cancer, breast cancer, lung cancer, pancreatic cancer, bladder cancer, esophageal cancer, and bone cancer. Ginsenosides block a variety of enzymes required for tumor growth, which regulate an array of cell progression, such as nitric oxide synthase activity, protein kinase activity, epidermal growth factor receptor intrinsic kinase activity, and nuclear factor-kappaB activity. Ginsenosides also inhibit lipid peroxidation and the production of reactive oxygen species. Thus, ginsenosides can be used as an adjuvant to conventional cancer therapies to improve efficacy and/or reduce side effects through synergistic activity. In this review, we summarized the latest research advances of the anticancer effects of ginsenosides and their potential mechanisms.

Copyright
© 2020 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)
View full text (HTML)

Journal
eFood
Publication Date
2020/05
ISSN (Online)
2666-3066
DOI
https://doi.org/10.2991/efood.k.200512.001How to use a DOI?
Copyright
© 2020 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Hongwei Chen
AU  - Haixia Yang
AU  - Daidi Fan
AU  - Jianjun Deng
PY  - 2020
DA  - 2020/05
TI  - The Anticancer Activity and Mechanisms of Ginsenosides: An Updated Review
JO  - eFood
SN  - 2666-3066
UR  - https://doi.org/10.2991/efood.k.200512.001
DO  - https://doi.org/10.2991/efood.k.200512.001
ID  - Chen2020
ER  -