Tocotrienols in Bone Protection: Evidence from Preclinical Studies

Maureen L. Meister; Huanbiao Mo; Xiangming Ji; Chwan-Li Shen

doi:10.2991/efood.k.200427.001

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Volume 1, Issue 3, June 2020, Pages 217 - 225

Tocotrienols in Bone Protection: Evidence from Preclinical Studies

Authors

Maureen L. Meister¹, Huanbiao Mo¹, Xiangming Ji¹, Chwan-Li Shen²^{, 3}^{, *}

¹Department of Nutrition, Byrdine F. Lewis College of Nursing and Health Professions, Georgia State University, Atlanta, GA 30302, USA

²Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA

³Center of Excellence for Integrative Health, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA

^*Corresponding author. Email: leslie.shen@ttuhsc.edu

Corresponding Author

Chwan-Li Shen

Received 23 December 2019, Accepted 26 April 2020, Available Online 30 April 2020.

DOI: 10.2991/efood.k.200427.001 How to use a DOI?
Keywords: Vitamin E; bone strength; animals; cells
Abstract: Osteoporosis is a degenerative bone disease affecting millions, mostly the aging population. Osteoblasts and osteoclasts maintain the balance in bone resorption and formation. Changes occurring in the differentiation, proliferation and activity of these two cell types result in lower bone mass and microarchitecture deterioration, leading to compromised bone strength. Chronic inflammation and oxidative stress disrupt the balance between osteoblasts and osteoclasts. Tocotrienols, vitamin E isoforms with an unsaturated hydrophobic tridecyl chain, reduce oxidative stress and inflammation by downregulating reactive oxygen species, nuclear factor-κB activation and pro-inflammatory cytokines and upregulating the expression of antioxidant enzyme in bone cells. Consequently, tocotrienols increase bone mineralization, promote osteoblast differentiation, and suppress osteoclast formation and differentiation. In vivo studies using various animal models of osteoporosis show improved biomarkers of bone formation and bone strength with tocotrienol supplementation. Tocotrienol-mediated downregulation of the mevalonate pathway that provides substrates for the biological activities of small guanosine triphosphate-binding proteins may also contribute to the regulation of osteoblasts and osteoclasts. Clinical studies are needed to confirm the bone-protection offered by tocotrienols that are found in abundance in plant foods such as fruits, vegetables, nuts, seeds and oils, which are also known for their antioxidant and anti-inflammatory effects.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: eFood
Volume-Issue: 1 - 3
Pages: 217 - 225
Publication Date: 2020/04/30
ISSN (Online): 2666-3066
DOI: 10.2991/efood.k.200427.001 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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ris enw bib

TY  - JOUR
AU  - Maureen L. Meister
AU  - Huanbiao Mo
AU  - Xiangming Ji
AU  - Chwan-Li Shen
PY  - 2020
DA  - 2020/04/30
TI  - Tocotrienols in Bone Protection: Evidence from Preclinical Studies
JO  - eFood
SP  - 217
EP  - 225
VL  - 1
IS  - 3
SN  - 2666-3066
UR  - https://doi.org/10.2991/efood.k.200427.001
DO  - 10.2991/efood.k.200427.001
ID  - Meister2020
ER  -

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