Protein-Protein interactions (PPIs) are vital for explaining the structural and functional architecture of the cell. To have a wider comprehension of the mechanisms, finding driver proteins that are vital for the control of the said network is a pertinent task in systems biology. Lately, it has become...

Computer tomography (CT) have been routinely used for the diagnosis of lung diseases and recently, during the pandemic, for detecting the infectivity and severity of COVID-19 disease. One of the major concerns in using machine learning (ML) approaches for automatic processing of CT scan images in clinical...

Schizophrenia is a chronic, severe mental disorder that affects the way a person thinks, acts, expresses emotions, perceives reality, and relates to others. Metatranscriptomics analysis enables understanding of how the micro biome responds to the environment by studying the functional analysis of genes...

Background: A neurodegenerative disorder in the elderly individuals. It is a type of dementia that affects memory subsequently followed by executive dysfunction, confusion, agitation, and behavioral disturbances. Three causative genes have been associated with autosomal dominant familial AD (APP, PSEN1,...

Buruli ulcer is caused primarily by Mycobacterium ulcerans. Due to its high association with the Buruli ulcer, Mycobacterium ulcerans microbiota were used in the study. This microbiota taxon and functional profile have been identified thanks to advances in Metatranscriptomic Sequencing. Then there are...

Schizophrenia is a chronic psychiatric disorder with a heterogeneous genetic and neurobiological background, it is one of the mental disorder which is common all over the world. Genes associated with Schizophrenia are DRD2, ERBB4, GRIA1, GRIN2A, GRM3. Among its related pathways/superpathways are Dopaminergic...

India’s marital culture is evolving. Relationship boundaries are becoming more diffused as a result of nuclear families, women being monetarily independent, and a reduction in social inhibitions. Due to COVID-19, there was a rapid change in the workplace environment where the line between the work and...

In this study we carried out a comprehensive analysis of SARS-CoV-2 mutations and their spread in India over the past two years of the pandemic (27th Jan’ 2020 – 8th Mar’ 2022). The analysis covers four important timelines, viz., the early phase, followed by the first, second and third waves of the pandemic...

Background: The next generation techniques has revolutionalized the biology era. In this work we are using Chromatin immunoprecipitation (ChiP) technique on the ChIP–seq of Gamma-Amino Butyric Acid (GABA). GABA is a brain-made chemical. It also found in some foods. The effect of GABA in brain is anti-seizure...

ChIP-sequencing (Chromatin immunoprecipitation) is a new method for genome wide mapping of protein binding sites on DNA. ChIP-sequencing helps to understand better the mechanisms of transcription factors, cofactors and histone modifications as well the regulation of gene expressions. The high degree...

Sandhoff’s disease is a lysosomal disorder. It’s an inherited lipid storage disease. Progressively destroys the nerve cells in brain and spinal cord. It’s a rare inherited disorder. Which is commonly seen in infants. Here I took the HEXB gene from Sandhoff’s disease because we did motif analysis and...

The discovery of a bacterium, Helicobacter pylori that is resident in the human stomach chronic disease (peptic ulcer and gastric cancer) was radical on many levels. Studies of this genetic diversity in strains isolated from various locations across the globe. The goal of this study was to determine...

Background: Bacterial vaginosis (BV) is a vaginal disease commonly caused by bacteria which most commonly causes abnormal vaginal discharge during women’s reproductive-age. BV is characterized by a shift within the vaginal flora from the dominant Lactobacillus to a polymicrobial flora and is further...

Cervicitis is an inflammation of the cervix, the lower, narrow end of the uterus that opens into the vagina. Basically, it causes inflammation of the uterine cervix. Cervicitis is a clinical syndrome characterised by inflammation of primarily the columnar epithelium of the uterine endocervix. The bacteria...

Tuberculosis caused by bacteria Mycobacterium tuberculosis. The bacteria usually attack the lungs, but TB bacteria can attack any part of the body such as the kidney, spine and brain. Mycobacterium tuberculosis in lungs microbiome can be studied by metamorphic mechanization specifically metatransriptomics...

Background: Nipah virus encephalitis causing microbiome Nipah henipavirus was taken in this work which is the causative factor for encephalitis condition in humans. The fruit bats of Pteropus genus are the natural reservoir and acts as a carrier of this Nipah henipavirus. The phylogeny, functional profile...

Introduction: Nanotechnology has received a lot of attention in recent years because of its wide range of applications in all scientific fields. Agriculture could benefit from the use of nanoparticles. In today’s world, sustainable agriculture is essential. Smartly designed nanoparticles, such as nanozeolites,...

Lung adenocarcinoma is an imminent principal cancer that causes a huge number of mortality for both men and women because of the respiratory epithelium. The survival rate analysis of patients improved year by year by using bioinformatics tools. The purpose of this research aimed to investigate the PPI...

Ambulance Routing Problem (ARP) is the part of Emergency Medical Services (EMS), which provide timely medical help for those who are in need. In Medical emergency situation, the key concern is, to provide early treatment. Relocating patients quickly to neighboring medical facilities is extremely difficult...