Establishing the Taxa with Phylogenetic Profile and in-silico Ayurvedic Remedy of Cervicitis Microbiome

DOI

10.2991/978-94-6463-164-7_15How to use a DOI?

Keywords

Cervicitis; Microbiome; Metagenomics; Taxonomic; Gene Receptor; Docking; Pathway Analysis

Abstract

Cervicitis is an inflammation of the cervix, the lower, narrow end of the uterus that opens into the vagina. Basically, it causes inflammation of the uterine cervix. Cervicitis is a clinical syndrome characterised by inflammation of primarily the columnar epithelium of the uterine endocervix. The bacteria associated with cervicitis is Mycoplasm hominis, which is a small bacterium that has the ability to cause cervicitis in the female and male genital areas. Mycoplasma hominis has a triple-layered membrane, no cell wall, and a highly pleomorphic shape and size. They lack even cell wall precursors like muramic acid or diaminopimelic acid. Because of their ability to inhibit cell wall synthesis, commonly used antibiotics are generally ineffective. One study suggested that up to 21% of men and 54% of women assessed with a sexually transmitted disease clinically showed signs and symptoms of cervicitis, indicating the importance of improving treatment strategies for women and men. Due to its association with serious complications like infertility, cervicitis should be promptly investigated and treated. The development of next-generation sequencing (NGS) techniques has enabled researchers to study and understand the world of microorganisms from broader and deeper perspectives. 16S rDNA sequencing, also known as metagenomics, is a fundamental sequencing strategy used in the identification and characterization of spices. Metagenomics has paved the way for drug development against the genetic potential of microorganisms that cannot be grown in vitro or in the laboratory but can infect humans. Molecular docking methodologies are of great importance in the planning and design of new drugs. The goal of these methods is to predict the experimental binding mode and affinity of a small molecule within the binding site of the receptor target of interaction as well as to identify a pathway.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Milan Khandelwal
AU  - I. A. Shylesh Murthy
AU  - Preenon Bagchi
PY  - 2023
DA  - 2023/06/05
TI  - Establishing the Taxa with Phylogenetic Profile and in-silico Ayurvedic Remedy of Cervicitis Microbiome
BT  - Proceedings of the Joint 3rd International Conference on Bioinformatics and Data Science (ICBDS 2022)
PB  - Atlantis Press
SP  - 201
EP  - 220
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-164-7_15
DO  - 10.2991/978-94-6463-164-7_15
ID  - Khandelwal2023
ER  -