Proceedings of the Joint 3rd International Conference on Bioinformatics and Data Science (ICBDS 2022)

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Motif and Pathway Identification with Designing Novel Ligands for Sandhoff Disease

Authors
M. Swathi1, *, Milan Khandelwal2, Preenon Bagchi1, 2, 3
1Padmashree Institute of Management and Science, Bangalore, India
2Vasishth Academy of Advanced Studies and Research (Sarvasumana Association), Bangalore, India
3MGM Institute of Biosciences and Technology, Aurangabad, India
*Corresponding author. Email: swathi4545m@gmail.com
Corresponding Author
M. Swathi
Available Online 5 June 2023.
DOI
10.2991/978-94-6463-164-7_12How to use a DOI?
Keywords
ChiP-seq; HEXB gene; Docking; Ligand; computational drug design
Abstract

Sandhoff’s disease is a lysosomal disorder. It’s an inherited lipid storage disease. Progressively destroys the nerve cells in brain and spinal cord. It’s a rare inherited disorder. Which is commonly seen in infants. Here I took the HEXB gene from Sandhoff’s disease because we did motif analysis and peak, pathway identification. ChIP sequencing is used for the analysis of protein and DNA interactions. I got the result of high-quality immunoprecipitation ChIP Peak is detected in our results which imply high concentration of DNA binding protein genes. Molecular docking is a technique which is used for the computational drug designing, by using docking one can predict the interactions between the macromolecules and the micro-molecules. A well-known in-silico structure-based technique utilized extensively in drug development is molecular docking.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the Joint 3rd International Conference on Bioinformatics and Data Science (ICBDS 2022)
Series
Advances in Health Sciences Research
Publication Date
5 June 2023
ISBN
978-94-6463-164-7
ISSN
2468-5739
DOI
10.2991/978-94-6463-164-7_12How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - M. Swathi
AU  - Milan Khandelwal
AU  - Preenon Bagchi
PY  - 2023
DA  - 2023/06/05
TI  - Motif and Pathway Identification with Designing Novel Ligands for Sandhoff Disease
BT  - Proceedings of the Joint 3rd International Conference on Bioinformatics and Data Science (ICBDS 2022)
PB  - Atlantis Press
SP  - 147
EP  - 156
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-164-7_12
DO  - 10.2991/978-94-6463-164-7_12
ID  - Swathi2023
ER  -