Proceedings of the Joint 3rd International Conference on Bioinformatics and Data Science (ICBDS 2022)

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Ayur-Informatics-Establishing Ligands for Schizophrenic Receptors from Ayurvedic Medicinal Herbs

Authors
Rushikesh Shelke1, *, I. A. Shylesh Murthy2, Preenon Bagchi1, 2, 3
1Padmashree Institute of Management and Sciences, Bengaluru, India
2Vasishth Academy of Advanced Studies and Research, (Sarvasumana Association), Bengaluru, India
3MGM Institute of Biosciences and Technology, Aurangabad, India
*Corresponding author. Email: rushikeshshelke2141999@gmail.com
Corresponding Author
Rushikesh Shelke
Available Online 5 June 2023.
DOI
10.2991/978-94-6463-164-7_7How to use a DOI?
Keywords
Schizophrenia; Ayurveda; genes; docking; ligand-receptorinteraction; phytocomponents; homology modelling
Abstract

Schizophrenia is a chronic psychiatric disorder with a heterogeneous genetic and neurobiological background, it is one of the mental disorder which is common all over the world. Genes associated with Schizophrenia are DRD2, ERBB4, GRIA1, GRIN2A, GRM3. Among its related pathways/superpathways are Dopaminergic synapse and Neuroactive ligand-receptor interaction used in this work. Plant phytocomponents used in this work: Withania sominifera, Melisa officinalis, Pipermethysticum, Veleriana and Hypericum perforatum. Using swiss model server homology modelling was done to the schizophrenic receptors using molinspiration server, phytocompounds were shortlisted based on Lipinski's rule of five. Further docking was done with the phytocompounds as selected by molinspiration server with the schizophrenic receptors.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the Joint 3rd International Conference on Bioinformatics and Data Science (ICBDS 2022)
Series
Advances in Health Sciences Research
Publication Date
5 June 2023
ISBN
10.2991/978-94-6463-164-7_7
ISSN
2468-5739
DOI
10.2991/978-94-6463-164-7_7How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Rushikesh Shelke
AU  - I. A. Shylesh Murthy
AU  - Preenon Bagchi
PY  - 2023
DA  - 2023/06/05
TI  - Ayur-Informatics-Establishing Ligands for Schizophrenic Receptors from Ayurvedic Medicinal Herbs
BT  - Proceedings of the Joint 3rd International Conference on Bioinformatics and Data Science (ICBDS 2022)
PB  - Atlantis Press
SP  - 81
EP  - 90
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-164-7_7
DO  - 10.2991/978-94-6463-164-7_7
ID  - Shelke2023
ER  -