The Effects of Binder on the Physical Characteristic of Squeezed Rhizome of Kaempferia galanga L Lozenges

DOI

10.2991/hsic-17.2017.41How to use a DOI?

Keywords

Kaempferia galanga; Gelatin; HPMC 1920 3 cps; PVP K-30; wet granulation; lozenges.

Abstract

The lozenge is one of the drugs to overcome a sore throat. This contained an active ingredient can be either a synthetic or herbal materials. Kaempferia galanga L is a medicinal plant that able to rrelieve cough and sore throat. So, its potential made be lozenges. Lozenges are compressed tablets which it must be using the binders on formulation. Objectives: This study was to investigate the effect of the binder to the physical characteristic of squeezing rhizome of Kaempferia galanga lozenges using mannitol base. The binder used were gelatin, Hydroxypropylmethylcellulose (HPMC) 1290 cps and Polyvinylpyrrolidone (PVP) K30 at 1%, 2%, and 3% concentrations. Methods: The squeezed rhizome of Kaempheria galanga L was dried using mannitol. The lozenges were prepared by a wet granulation method and compressed by a hydraulic press at 2-ton pressures. Lozenges had been evaluated, including hardness, fragility, and dissolves time of lozenges. Conclusion: Lozenges used the Gelatine and PVP K30 in the concentration of 2% and 3%, both of them were as well at the range. While the lozenges used the HPMC 1290 cps provides good results at the concentration of 3%. All parameters are dependent on the type, quality and concentration of a binder.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Uswatun Chasanah
AU  - Fairuzly Yulian
AU  - Rozki Yulianty
AU  - Adzan Irianto
AU  - Achmad Radjaran
PY  - 2017/10
DA  - 2017/10
TI  - The Effects of Binder on the Physical Characteristic of Squeezed Rhizome of Kaempferia galanga L Lozenges
BT  - Proceedings of the Health Science International Conference (HSIC 2017)
PB  - Atlantis Press
SP  - 264
EP  - 270
SN  - 2468-5739
UR  - https://doi.org/10.2991/hsic-17.2017.41
DO  - 10.2991/hsic-17.2017.41
ID  - Chasanah2017/10
ER  -