Proceedings of the Health Science International Conference (HSIC 2017)

Black Cummin Extract (Nigella sativa Linn) on Spatial Memory Performance in Menopausal Model of Rat

Authors
Fathiyah Safithri, Kusuma Andriani
Corresponding Author
Fathiyah Safithri
Available Online October 2017.
DOI
https://doi.org/10.2991/hsic-17.2017.40How to use a DOI?
Keywords
Nigella Sativa Extract; Menopausal Model Of Rat; Spatial Memory Performance
Abstract

The loss of the ability for learning and memorizing is a prominent feature of dementia, which affects millions of menopausal women all over the world. Nigella sativa is a herbal medicine known to have estrogenic, antioxidant and neuroprotective effects thought to improve memory function in dementia. Objective : This present study investigated the effect of Nigella sativa extract (NS) administration on the spatial memory performance (SMP) of menopausal model of rat. Methods : Experimental with post test only control group design. Bilateral ovariectomy (OVX) was performed in all rats. Two weeks post OVX, the rat has a hypoestrogen condition. There were 6 experimental groups namely OVX group as control and 5 groups of OVX rats treated with NS (OVX +NS) with each dose of 1,25; 2,5; 5; 10 and 20 mg/kgBB. NS were administered after 2 weeks post OVX by intragastric gavage daily for 4 weeks. After NS administered, SMP was evaluated of each rat for 6 consecutive days using Water Morris Maze (WMZ). The time latency to reach the hidden platform was recorded. Result : On the sixth day of practice, the mean of time latency to reach the hidden platform by OVX+NS group with dose 1,25; 2,5 and 5 mg/kgBB were shorter than control group but not significant (P>0.05), while OVX+NS group in dose 10 and 20mg/kg were longer than control group (P>0.05). Conclusion : NS extract could not increased the SMP of OVX rats. Probably because NS is more effective to use since pre-menopause

Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the Health Science International Conference (HSIC 2017)
Series
Advances in Health Sciences Research
Publication Date
October 2017
ISBN
978-94-6252-413-2
ISSN
2468-5739
DOI
https://doi.org/10.2991/hsic-17.2017.40How to use a DOI?
Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Fathiyah Safithri
AU  - Kusuma Andriani
PY  - 2017/10
DA  - 2017/10
TI  - Black Cummin Extract (Nigella sativa Linn) on Spatial Memory Performance in Menopausal Model of Rat
BT  - Proceedings of the Health Science International Conference (HSIC 2017)
PB  - Atlantis Press
SP  - 254
EP  - 263
SN  - 2468-5739
UR  - https://doi.org/10.2991/hsic-17.2017.40
DO  - https://doi.org/10.2991/hsic-17.2017.40
ID  - Safithri2017/10
ER  -