Journal of Epidemiology and Global Health

In Press, Uncorrected Proof, Available Online: 13 January 2020

Early Initiation of ARV Therapy Among TB–HIV Patients in Indonesia Prolongs Survival Rates!

Authors
Tri Bayu Purnama*, Siti Maemun, Nina Mariana, Adria Rusli, Renti Mahkota
Universitas Islam Negeri Sumatera Utara, Deli Serdang, North Sumatera, Indonesia
*Corresponding author. Email: tbayu93@gmail.com
Corresponding Author
Tri Bayu Purnama
Received 17 July 2019, Accepted 21 December 2019, Available Online 13 January 2020.
DOI
https://doi.org/10.2991/jegh.k.200102.002How to use a DOI?
Keywords
Antiretroviral, TB–HIV coinfection, Survival analysis
Abstract

Background: The HIV epidemic remains a public health problem with rising tuberculosis (TB) numbers around the world. Antiretroviral (ARV) therapy (ART) is essential to increase the survival of patients with TB–HIV coinfection. The aim of this study is to investigate the effect of ARV treatment initiation within TB treatment duration for the survival of patients with TB–HIV coinfection.

Methods: This is a retrospective cohort study of patients with TB–HIV coinfection and who were ARV naive from Prof. Dr. Sulianti Saroso Infectious Disease Hospital between January 2011 and May 2014 (N = 275). The Kaplan–Meier method, bivariate with the log rank test, and multivariate with the Cox regression were applied in this study.

Results: Cumulative survival probability of the patients with TB–HIV coinfection receiving ARV in a year was 81.5%. The death rate in patients with TB–HIV coinfection who received late ART initiation during TB treatment is higher by 2.4 times (aHR = 2.4, 95% confidence interval: 1.3–4.5, p = 0.006) compared with the patients who were in early ART initiation and were thereafter adjusted by the location of Mycobacterium tuberculosis infection.

Conclusion:The effect of ART initiation is essential in the intensive phase (2–8 weeks) of anti-TB medication to increase the survival among TB–HIV coinfection group.

Copyright
© 2020 Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Journal of Epidemiology and Global Health
Publication Date
2020/01
ISSN (Online)
2210-6014
ISSN (Print)
2210-6006
DOI
https://doi.org/10.2991/jegh.k.200102.002How to use a DOI?
Copyright
© 2020 Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Tri Bayu Purnama
AU  - Siti Maemun
AU  - Nina Mariana
AU  - Adria Rusli
AU  - Renti Mahkota
PY  - 2020
DA  - 2020/01
TI  - Early Initiation of ARV Therapy Among TB–HIV Patients in Indonesia Prolongs Survival Rates!
JO  - Journal of Epidemiology and Global Health
SN  - 2210-6014
UR  - https://doi.org/10.2991/jegh.k.200102.002
DO  - https://doi.org/10.2991/jegh.k.200102.002
ID  - Purnama2020
ER  -