Artery Research

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2994 articles
Conference Abstract

P69 RELATIONSHIP BETWEEN CAROTID INTIMA-MEDIA THICKNESS, ENDOTHELIAL FUNCTION, AORTIC STIFFNESS AND CARDIOVASCULAR EVENTS AMONG METABOLIC SYNDROME SUBJECTS

Ligita Ryliškytė, Rokas Navickas, Roma Puronaitė, Agnė Jucevičienė, Aleksandras Laucevičius
Pages: 98 - 98
Objective: The aim of this study was to evaluate predictive value of main arterial markers for cardiovascular (CV) events in subjects with metabolic syndrome (MetS). Methods: A prospective study enrolled 2728 middle-aged (53.9 ± 6.2 years old, 63% women) MetS patients of the Lithuanian High Cardiovascular...
Conference Abstract

P19 INFLUENCE OF BRACHIAL ARTERY STIFFNESS ON FLOW-MEDIATED DILATATION IN HEALTHY YOUNG AND OLDER POPULATIONS

Kunihiko Aizawa, Sara Sbragi, Alessandro Ramalli, Piero Tortoli, Francesco Casanova, Carmela Morizzo, Clare Thorn, Angela Shore, Phillip Gates, Carlo Palombo
Pages: 98 - 98
Background: Increased brachial artery (BA) stiffness has previously been shown to affect the magnitude of FMD response in patients with high cardiovascular risk. However, it is unclear whether increased BA stiffness explains the diminished FMD response typically observed in a healthy older population....
Conference Abstract

PO-36 EFFECTS OF FIXED VERSUS AUTO-TITRATING CONTINUOUS POSITIVE AIRWAY PRESSURE ON VASCULAR FUNCTION IN PATIENTS WITH RESISTANT HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA

Karen Tran, R.J. Kimoff, S.S. Daskalopoulou
Pages: 98 - 99
Introduction: Obstructive sleep apnea (OSA) is a common cause of resistant hypertension. We investigated the effects of 2 modalities of positive airway pressure; fixed continuous airway pressure (fCPAP) versus auto-titrating positive airway pressure (APAP) on arterial function in subjects with resistant...
Conference Abstract

P70 FINGER-TOE PULSE WAVE VELOCITY (FTPWV) MEASURED BY POPMèTRE® DEVICE IN PATIENTS WITH ANKYLOSING SPONDYLITIS

Guillermo Alanis-Sánchez, Carlos Ramos-Becerra, Ernesto Cardona-Muñóz, Diego Castañeda-Zaragoza, David Cardona-Muller, Hakim Khettab, Stephen Laurent, Pierre Boutouyrie, Hasan Obeid, Magid Hallab, Valeria Diaz-Rizo
Pages: 98 - 99
Background: Ankylosing spondylitis (AS) is an inflammatory autoimmune disease. AS is a prototype form of spondyloarthropathies (SpA). The precise ethology of AS has not been fully understood. But Inflammation has a critical role in the pathogenesis of the disease. Extra skeletal organs may also be affected...
Conference Abstract

P20 AUGMENTATION INDEX ASSOCIATES WITH IMPAIRED EARLY VENTRICULAR EJECTION

Haotian Gu, Gerry Carr-White, John Chambers, Phil Chowienczyk
Pages: 98 - 99
Background: Previously regarded as a measure of pressure wave reflection, central augmentation index (cAI) may be influenced by the pattern of early ventricular ejection. We examined the relationship of cAI to first-phase ejection-fraction (EF1), a measure of ventricular ejection up to the time of the...
Research Article

Enhancing coronary Wave Intensity Analysis robustness by high order central finite differences

Simone Rivolo, Kaleab N. Asrress, Amedeo Chiribiri, Eva Sammut, Roman Wesolowski, Lars Ø. Bloch, Anne K. Grøndal, Jesper L. Hønge, Won Y. Kim, Michael Marber, Simon Redwood, Eike Nagel, Nicolas P. Smith, Jack Lee
Pages: 98 - 109
Background: Coronary Wave Intensity Analysis (cWIA) is a technique capable of separating the effects of proximal arterial haemodynamics from cardiac mechanics. Studies have identified WIA-derived indices that are closely correlated with several disease processes and predictive of functional recovery...

22. BP VARIABILITY AS WELL AS MEAN BP FROM AMBULATORY BLOOD PRESSURE AND HOME BLOOD PRESSURE CORRELATES WELL WITH TARGET ORGAN DAMAGE IN UNTREATED HYPERTENSIVE PATIENTS

Ae-Young Her, Se-Joong Rim, Pil-Ki Min, Young Won Yoon, Bum-Kee Hong, Hyuck Moon Kwon
Pages: 99 - 99
Background: We sought to assess the relation of ambulatory blood pressure(ABP) measurement and home blood pressure(HBP) measurement with target organ damage using BP variability(BPV) as well as mean BP in untreated hypertensive patients. Methods: Seventy-nine untreated patients with hypertension(men...

21. THE ASSOCIATION OF BETWEEN CORONARY SPASM AND B-TYPE NATRIURETIC PEPTIDE AND PULSE WAVE VELOCITY

Jin Oh Na, Chang Gyu Park, Jae Hyoung Park, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Seung-Woon Rha, Hong Seog Seo, Dong Joo Oh
Pages: 99 - 99
Background: Coronary spasm cause transient LV dysfunction and consequently may increase BNP by chance. However, the correlation between coronary spasm and BNP has not been verified. We investigated the association between coronary spasm and BNP and pulse wave velocity (PWV) in patients with preserved...

20. CORRELATION OF AORTIC DISTENSIBILITY WITH CORONARY ATHEROSCLEROSIS IN ANGINA PATIENTS

Gwang-Sil Kim, Young-Sub Byun, Byoung Kwon Lee, Choong-Won Goh, Kun-Joo Rhee
Pages: 99 - 99
Background: Arterial stiffness is associated with an increased risk of cardiovascular disease. However, limited evidence exists on whether arterial stiffening correlates not only with cardiovascular events, but also with subclinical atherosclerotic lesions. This study aimed to provide information on...
Conference Abstract

19. AORTIC DISTENSIBILITY IS MORE CLOSELY ASSOCIATED WITH CAROTID INTIMA MEDIA THICKNESS THAN AORTIC INTIMA-MEDIA THICKNESS IN THE PATIENTS WITH ISCHEMIC STROKE

Hyun Ju Yoon, Min Gu Lee, Jum Seok Ko, Kun Ho Park, Ju Han Kim, Younggeun Ahn, Myung Ho Jeong, Jung Gwan Cho, Jung Chaee Kang, Jong Chun Park
Pages: 99 - 99
Background: The aorta plays a central role for a modulator in whole cardiovascular system by its elasticity. If the elasticity was decreased, aortic distensibility was also decreased and stiffness index was elevated. In this study, we investigated the relationship between aortic distensibility calculated...
Conference Abstract

P71 TROPONIN INCREASE AND SUBENDOCARDIAL OXYGEN SUPPLY AND DEMAND IMBALANCE IN CARDIAC AMYLOIDOSIS

Lucia Salvi, Paolo Salvi, Andrea Grillo, Gianfranco Parati, Francesco Banfi, Stefano Perlini
Pages: 99 - 99
Background: The increase in troponin is a cardiac amyloidosis (CA) peculiarity. The most acclaimed hypothesis is direct toxicity of amyloid fibrils on cardiomyocytes, but a subendocardial ischemia due to discrepancy between oxygen supply and demand imbalance has not been investigated yet. Methods: 129...
Conference Abstract

P21 REDUCTION OF CARDIAC PRE-LOAD HAS ANTITHETICAL EFFECTS ON BLOOD PRESSURE AND ARTERIAL STIFFNESS: IS BLOOD PRESSURE THE MAIN DETERMINANT OF WITHIN-SUBJECT VARIATION IN PULSE WAVE VELOCITY?

Luca Faconti, Bushra Farukh, Andrii Boguslavskyi, Phil Chowienczyk
Pages: 99 - 99
Objective: Blood pressure (BP) is considered the most important determinant of within-subject variation in pulse wave velocity (PWV) and the possibility of altering arterial stiffness independently of BP is still a matter of debate. When investigating acute effects of a reduction in cardiac pre-load,...
Conference Abstract

P1.30 INDICES OF ARTERIAL STIFFNESS AND RAISED BLOOD PRESSURE AMONGST PUBLIC SCHOOL CHILDREN IN GUJARAT, INDIA

J.V. Patel, R. Potluri, A. Gunarathne, J.K. Cruickshank, GYH Lip, D. Prabharkaran, P.S. Gill, E.A. Hughes
Pages: 99 - 99
Conference Abstract

P72 AORTIC PULSE WAVE VELOCITY IN PATIENTS WITH COPD: 5-YEAR DATA FROM THE ARCADE STUDY

Nichola Gale, Mahfoudha Al Shezawi, Maggie Munnery, Barry Mcdonnell, John Cockcroft
Pages: 99 - 100
Background: Cardiovascular (CV) disease is a major cause of morbidity and mortality in COPD 1 . Aortic pulse wave velocity (AoPWV), an independent predictor of CV risk, is elevated in COPD 2 , however, there have been no longitudinal studies of AoPWV in COPD. The Assessment of Risk in Chronic Airways...
Conference Abstract

P22 CIRCADIAN VARIATIONS IN THE CARDIOVASCULAR SYSTEM

Thomas Weber, Siegfried Wasserheurer, Arno Schmidt-Trucksäss, Enrique Rodilla Sala, Piotr Jankowski, Maria Lorenza Muisan, Cristina Giannatasio, Ian Wilkinson, Joerg Kellermair, Bernhard Hametner, Jose Maria Pascual, Robert Zweiker, Danuta Czarnecka, Anna Paini, Massimo Salvetti, Allessandro Maloberti, Peter Fitscha, Kai Mortensen, Elisabeth Wagner, Carmel McEniery, Cornelia Ablasser
Pages: 99 - 99
Background: Comprehensive information on 24-hour profiles of pulsatile as well as steady-state hemodynamics in humans is not available yet. Methods: In 693 healthy individuals (352 men) free from antihypertensive drugs, we performed 24-hour blood pressure (BP) monitoring with a validated oscillometric...
Conference Abstract

PO-37 THE IMPACT OF INTRADIALYTIC PEDALING EXERCISE ON ARTERIAL STIFFNESS IN A HEMODIALYSIS POPULATION

Alexandra B. Cooke, Vincent Ta, Yessica-Haydee Gomez, Sameena Iqbal, Stella S. Daskalopoulou
Pages: 99 - 100
Objectives: Hemodialysis patients are at greater risk of increased arterial stiffness. Regular aerobic exercise has been shown to reduce arterial stiffness in hemodialysis patients. However, the impact of a more realistic intradialytic form of exercise, such as pedaling, is unclear. Therefore, we aimed...
Conference Abstract

P73 AORTIC BUT NOT PERIPHERAL PULSE WAVE VELOCITY IS IMPROVED AFTER HEART RATE TARGETED AEROBIC PHYSICAL TRAINING IN METABOLIC SYNDROME SUBJECTS

Ieva Slivovskaja, Jurate Balsyte, Ligita Ryliskyte, Jolita Badariene, Rokas Navickas, Aleksandras Laucevicius
Pages: 100 - 100
Objective: To evaluate the response of aortic and peripheral arterial stiffness parameters to heart rate (HR) targeted exercise training in metabolic syndrome (MS) subjects. Methods: This cohort study included 170 individuals with MS (mean age 53.3 ± 6.9 years, 55% women). The subjects were recruited...
Conference Abstract

P23 PREDICTION OF TOTAL AND CAUSE-SPECIFIC MORTALITY INCIDENCE AS WELL AS CARDIOVASCULAR MORBIDITY BY USE OF NON-INVASIVE MEASUREMENT OF CAROTID- FEMORAL PULSE WAVE VELOCITY AS A MEASURE OF ARTERIAL STIFFNESS

Peter Nilsson, Mikael Gottsäter, Abd al-Hakim Fatehali
Pages: 100 - 100
Objective: Arterial stiffness (AS) increases with age and predicts total mortality and total cardiovascular (CV) events. It has also been shown that positive family history (FH+) of cardiometabolic disease influences AS. We aimed to: 1) examine if AS predicts total mortality among elderly subjects, as...
Conference Abstract

P1.34 VALIDATION OF THE WORKING PRINCIPLE OF THE ARTERIOGRAPH, A NEW DEVICE TO MEASURE PULSE WAVE VELOCITY

B. Trachet, J.G. Kips, A. Swillens, M.L. De Buyzere, B. Suys, N. Stergiopulos, P. Segers
Pages: 100 - 100
Conference Abstract

P74 SLEEP QUALITY IS ASSOCIATED WITH CEREBROVASCULAR FUNCTION IN INDIVIDUALS WITH MULTIPLE SCLEROSIS

Georgios Grigoriadis, Alexander J. Rosenberg, Sang Ouk Wee, Elizabeth C. Schroeder, Garett Griffith, Tracy Baynard
Pages: 100 - 100
Introduction: Individuals with multiple sclerosis (MS) exhibit impaired cerebrovascular function and have poor sleep quality. In the general population, poor sleep contributes to cerebrovascular dysfunction and is related to cardiovascular disease (CVD). Improving sleep quality may have beneficial effects...
Conference Abstract

P24 SEX-SPECIFIC PULSE WAVE VELOCITY CUT-OFFS IMPROVE SURVIVAL ANALYSIS IN PATIENTS WITH SUSPECTED CORONARY ARTERY DISEASE

Christopher C. Mayer, Bernhard Hametner, Katy Whitelegg, Thomas Weber, Siegfried Wassertheurer
Pages: 100 - 100
Objectives: There is evidence for sex and age influences on pulse wave velocity (PWV). Guidelines suggest a sex-independent cut-off for PWV. It is not obvious that an age- and blood-pressure-independent cut-off is suitable in different populations [1, 2]. Thus, the aim is to investigate the suitability...
Conference Abstract

P75 DIFFERENTIAL ELASTIN DEGRADATION AND MICROMECHANICAL PROPERTIES IN ASCENDING AORTIC ANEURYSM GROUPS: STATISTICAL MODELLING

Ya Hua Chim, Hannah Davies, Francesco Diaz De la O, Mark Field, Jill Madine, Riaz Akhtar
Pages: 100 - 100
Background: Elastin microstructure is an important factor in aortic aneurysms. However, it is unclear whether elastin microstructure varies in different ascending aneurysm aetiologies, and how this relates to micromechanical behaviour. Objective to combine in vitro experimentation and statistical modelling...
Conference Abstract

P25 VASCULAR AGING IS ASSOCIATED WITH THE SEVERITY OF CEREBRAL WHITE MATTER LESION LOAD

Lisanne Tap, Annegreet van Opbroek, Wiro Niessen, Marion Smits, Francesco Mattace- Raso
Pages: 100 - 101
Background: Blood pressure (BP) levels and aortic stiffness are associated with the presence of cerebal small vessel disease, whereas little is known on the possible association of BP levels, aortic stiffness and the severity of cerebral small vessel disease. In a pilot study we investigated whether...
Conference Abstract

P1.36 A PRELIMINARY STUDY FOR THE EVALUATION OF LARGE ARTERY STIFFNESS: A NON CONTACT APPROACH

M. De Melis, U. Morbiducci, L. Scalise, E.P. Tomasini, D. Delbeke, R. Baets, L.M. Van Bortel, P. Segers
Pages: 100 - 101
Conference Abstract

P76 CAROTID THERMAL HETEROGENEITY AND DYSLIPIDEMIA: THE HEAT IS ON

Iosif Koutagiar, Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, Ioannis Skoumas, Evangelia Sigala, Vasiliki Gardikioti, Stavroula Pantou, Angeliki Rigatou, Nikolaos Ioakeimidis, Christos Georgakopoulos, Nikitas-Alexandros Skliros, Georgios Benetos, Spiros Galanakos, Dimitrios Tousoulis
Pages: 100 - 101
Background: Microwave Radiometry (MWR) is a new validated method, which allows evaluation of thermal heterogeneity of carotid arteries and is associated with inflammation.Purpose: The aim of this pilot study was to determine if thermal heterogeneity in the carotid arteries is associated with aortic elastic...
Conference Abstract

P77 TARGETED LIPIDOMICS OF ARTERIAL STIFFNESS AND HEMODYNAMICS IN ATHEROSCLEROSIS

Kaido Paapstel, Jaak Kals, Jaan Eha, Kaspar Tootsi, Aigar Ottas, Anneli Piir, Mihkel Zilmer
Pages: 101 - 101
Objectives: This study examined relationships between lipidomic profile, arterial function and hemodynamics in coronary artery disease (CAD) patients, peripheral arterial disease (PAD) patients and healthy controls. Methods: We studied 52 patients with CAD, 32 patients with PAD, and 40 apparently healthy...
Conference Abstract

P27 REPLACED RIGHT HEPATIC ARTERY AND INTERLOBAR BRIDGE OF LIVER WITH UNUSUAL ARTERIAL SUPPLY OF IVTH SEGMENT

Mehtap Yuksel, Turan Koc, Sezgin Ilgi
Pages: 101 - 101
A replaced right hepatic artery (rRHA) arising from the superior mesenteric artery and an interlobar parenchymal bridge over the sagittal fissure of liver have been observed on a 64 year old formalin-fixed male cadaver in the anatomy laboratory. As we followed a detailed segmental anatomy, encountered...
Conference Abstract

P1.38 CONVERSION BETWEEN DEFINITIONS OF PULSE WAVE VELOCITY

S.J. Vermeersch, E. Rietzschel, T.C. Gillebert, S. Laurent, P. Boutouyrie, P. Segers
Pages: 101 - 101
Conference Abstract

P78 PRESSURE-INDEPENDENT ROLE OF THE AUTONOMIC NERVOUS SYSTEM IN THE REGULATION OF ARTERIAL STIFFNESS IN SUBJECTS WITH ESSENTIAL HYPERTENSION

Luca Faconti, Bushra Farukh, Philip J. Chowienczyk
Pages: 101 - 101
Objective: To test if arterial stiffness (AS) can be modulated by the autonomic nervous system (ANS) independently of blood pressure (BP) in hypertensive patients. Material and methods: AS was measured by carotid-femoral pulse wave velocity (cfPWV) using the SphygmoCor device (AtCor Medical, Australia)....
Conference Abstract

P28 DETERMINANTS OF ARTERIAL STIFFNESS AS MARKER OF EARLY VASCULAR AGING IN PHYSICIANS POPULATION

Elena Shavarova, Eldar Kazahmedov, Artemiy Orlov, Zhanna Kobalava
Pages: 101 - 101
Objective: To analyze determinants of arterial stiffness in physician’s population. Methods: Observational multicenter study of doctor’s vascular health conducted in 12 Russian cities (VICTORIA study). Demographics; smoking status; anamnesis of arterial hypertension (AH) with/without therapy, medications,...
Conference Abstract

P79 AORTIC VISCOELASTIC PROPERTIES AND ALTERED ELECTROMECHANICAL CARDIO-AORTIC CONNECTION IN PATIENTS WITH CARDIAC AMYLOIDOSIS

Lucia Salvi, Paolo Salvi, Andrea Grillo, Stefano Perlini, Gianfranco Parati
Pages: 101 - 101
Background: Cardiac amyloidosis (CA) is an infiltrative disorder caused by deposition of amyloid fibrils in the myocardial extracellular matrix. A wide scientific literature regarding amyloid heart disease is available, but no data about aortic viscoelastic properties. This studio has the aims to start...
Conference Abstract

P29 TOTAL LONGITUDINAL DISPLACEMENT (TLOD) OF THE COMMON CAROTID ARTERY (CCA) DOES NOT DIFFER BETWEEN PATIENTS WITH MODERATE OR HIGH CARDIOVASCULAR RISK (CV) AND PATIENTS AFTER ACUTE MYOCARDIAL INFARCTION (AMI)

Urtė Gargalskaitė, Pranas Šerpytis, Karolis Azukaitis, Rokas Navickas, Vilma Dzenkeviciute, Jolita Badariene, Zaneta Petrulioniene, Kristijonas Česas
Pages: 101 - 101
Background: Total longitudinal displacement (tLoD) of the common carotid artery (CCA) wall is a novel ultrasound marker of vascular function that can be evaluated using modified speckle tracking techniques. Decreased CCA tLoD has already been shown to be associated with diabetes and was shown to predict...
Conference Abstract

P80 ANALYSIS OF ENDOTHELIAL FUNCTION IN MALE STUDENTS IN SOUTHERN BRAZIL: THE ROLE OF PHYSICAL ACTIVITY

Marcos Paulo Camboim, Bruna Eibel, Lucia Pallanda, Salvador Neto, Gustavo Waclawovsky, Vitor Kunrath
Pages: 101 - 102
Context: School adolescents in Porto Alegre have a mean physical inactivity (PI) <300 min/week of 43%, and another 13% do not perform physical activities. In this scenario, endothelial cells that regulate vascular homeostasis by the expression of bioactive mediators may be influenced by inflammatory...
Conference Abstract

P30 THE ROLE OF NOVEL BIOMARKERS IN ARTERIAL STIFFNESS, AND IN PREDICTING FURTHER VASCULAR EVENTS AFTER TIA AND LACUNAR STROKE

Esme Girdwood, Manuela Mengozzi, Eva Bunting, Jean Timeyin, Pietro Ghezzi, Chakravarthi Rajkumar
Pages: 101 - 102
Objective: To explore the role of biomarkers (hsCRP, sRANKL, PRDX1 and EPO) in arterial stiffness and in predicting further vascular events. Methods: Patients from the ongoing ASIST study each attended a laboratory visit within fourteen days of their diagnosed TIA or lacunar stroke. Arterial stiffness...
Research Article

Implication of bone regulatory factors in human coronary artery calcification

Alexandros Alexopoulos, Stavros Peroukides, Vasiliki Bravou, John Varakis, Vlassios Pyrgakis, Helen Papadaki
Pages: 101 - 108
Background: Although emerging evidence suggests that vascular calcification constitutes an active process sharing common features with bone formation, several aspects of this process in human coronary artery calcification are still poorly understood. We therefore investigated the expression of key bone...
Research Article

Central Hemodynamic Parameters are Altered in Resistant Hypertensive Individuals

João Marcos de Menezes Zanatta, Fábio dos Santos Ricardi, Elizabeth do Espírito Santo Cestário, Tatiana Azevedo, Jéssica Rodrigues Uyemura, Luciana Neves Cosenso-Martin, Juan Carlos Yugar-Toledo, José Fernando Vilela-Martin
Pages: 101 - 105
Background: Systemic arterial hypertension (SAH) is one of the major risk factors related to the development of cardiovascular diseases (CVD). Sodium intake is linked to elevated blood pressure and can be estimated by 24-h urinary sodium excretion. The objective of this study was to correlate 24 h urinary...
Conference Abstract

P82 REDUCTION IN ENDOTHELIAL, BUT NOT MICROVASCULAR, FUNCTION DURING ACUTE INFLAMMATION: PRELIMINARY RESULTS

Elizabeth Schroeder, Thessa Hilgenkamp, Tracy Baynard, Bo Fernhall
Pages: 102 - 102
Acute inflammation is associated with increased risk for cardiovascular events and leads to reductions in conduit artery (flow-mediated dilation, FMD) and resistance vessel endothelial function. Whether this dysfunction during acute inflammation is further transmitted down the arterial tree to the microvasculature,...
Conference Abstract

P150 ARTERIAL STIFFNESS AND PROGRESSION OF CEREBRAL WHITE MATTER LESIONS IN ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES AND MATCHED CONTROLS: A 5-YEAR COHORT STUDY

Kristian Løkke Funck, Esben Laugesen, Pernille Høyem, Brian Stausbøll-Grøn, Won Kim, Leif Østergaard, Dora Zeidler, Troels Krarup Hansen, Per Løgstrup Poulsen
Pages: 102 - 102
Aim: Stroke is a frequent and feared complication in patients with type 2 diabetes. Arterial stiffness may improve current suboptimal risk prediction of stroke. However, studies in diabetes populations are lacking. We investigated the association between arterial stiffness progression (carotid-femoral...
Conference Abstract

OR-04 DECREASED AORTIC INERTANCE INCREASES SUSCEPTIBILITY OF LATE-SYSTOLIC LEFT VENTRICULAR EJECTION TO ARTERIAL WAVE REFLECTIONS

Timothy S. Phan, John K.-J. Li, Amer Ahmed Syed, Harry G. Oldland, Uzma Kewan, Scott R. Akers, Julio A. Chirinos
Pages: 102 - 102
Background: Left ventricular (LV) afterload patterns consisting of late-systolic loading has been linked to LV remodeling and fibrosis in a number of studies. The contributions from arterial wave reflections (WR) has therefore garnered much interest. Aortic dilation may facilitate the adverse effects...
Conference Abstract

OR-02 EFFECT OF ACUTE ISOKINETIC RESISTANCE EXERCISE ON SYSTEMIC ARTERIAL HEMODYNAMICS AND CEREBRAL BLOOD FLOW DYNAMICS: IS THERE A MISMATCH?

A. Rosenberg, S.O. Wee, E. Schroeder, K. Bunsawat, G. Grigoriadis, B. Fernhall, T. Baynard
Pages: 101 - 102
Resistance exercise (RE) is currently recommended for most adults and is important for reducing risk factors for cardiovascular and metabolic diseases, and improving quality of life. Despite functional and musculoskeletal benefits, high-intensity RE has been shown to acutely increase arterial stiffness...
Research Article

Therapeutic Effects of Interventional Therapy and Conservative Therapy on Lower Extremity Arteriosclerosis Obliterans and Risk Factors for Prognosis

Lingxiong Chen, Xuming Zhang, Fuyan Jiang, Zhida Yin, Jinqiu Xue, Chengmei Ruan, Lijiao Xie
Pages: 101 - 106
Background: Arteriosclerosis Obliterans (ASO) is an important cause for lower limb amputation. We aimed to compare the effects of interventional and conservative therapies on lower extremity ASO, and to analyze the risk factors for prognosis. Methods: Ninety-eight eligible patients were randomly divided...
Conference Abstract

P1.42 PRECLINICAL ATHEROSCLEROTIC DISEASE: IS IT A MARKER OF RISK OF CARDIOVASCULAR EVENTS?

P. Forcada, C. Kotliar, O. Montana, C. Schulte, S. Obregon, G. Millet, J. Guerrieri, D. Turri
Pages: 102 - 102
Conference Abstract

P83 DIFFERENT PROTOCOLS FOR EARLY CARDIAC REHABILITATION MODULATE THE VASCULAR FUNCTION OF INDIVIDUALS UNDERGOING CORONARY ARTERY BYPASS GRAFTING: RANDOMIZED CLINICAL TRIAL

Bruna Eibel, Gustavo Waclawovsky, Liliana Boll, Eduardo Barbosa, Maria Cláudia Irigoyen, Alexandre Lehnen
Pages: 102 - 102
Background: Cardiac rehabilitation with aerobic exercises is the first strategy as a non-pharmacological treatment in the postoperative period of individuals undergoing coronary artery bypass grafting (CABG) to improve functional capacity and vascular health. However, other exercise modalities remain...
Conference Abstract

P151 CENTRAL PULSE PRESSURE IS ASSOCIATED WITH AORTIC-BRACHIAL STIFFNESS MISMATCH IN PATIENTS WITH ARTERIAL HYPERTENSION AND DIABETES MELLITUS

Elena Troitskaya, Ekaterina Starostina, Zhanna Kobalava
Pages: 102 - 102
Background: Central pulse pressure (PP) is a surrogate measure of arterial stiffness (AS) and a predictor of cardiovascular events in type 2 diabetes mellitus (T2DM). AS gradient reflects the vascular ageing. The aim of the study: To evaluate the associations between 24-h central PP and parameters of...
Conference Abstract

OR-05 SEX DIFFERENCES IN VASCULAR STRUCTURE AND FUNCTION IN INDIVIDUALS WITH MULTIPLE SCLEROSIS AND HEALTHY CONTROLS

Thessa Hilgenkamp, Garett Griffith, Robert W. Motl, Tracy Baynard, Bo Fernhall
Pages: 102 - 103
Objectives: Cardiovascular disease is a leading cause of death in multiple sclerosis (MS), and recent data showed that subclinical markers of atherosclerosis are higher in MS as well. Prevalence of MS in men is much lower than in women, but their prognosis is much worse. Men with MS also have higher...
Conference Abstract

P1.43 FRAMINGHAM SCORE UNDERDIAGNOSES VASCULAR DISEASE IN PATIENTS UNDER CARDIOVASCULAR PREVENTION

P. Forcada, C. Kotliar, S. Obregon, O. Montana, C. Schulte, G. Millet, J. Guerrieri, D. Turri
Pages: 102 - 102
Conference Abstract

P84 RELATIONSHIP OF ARTERIAL STIFFNESS AND ANKLE-BRACHIAL INDEX

Gabriel Dimitrov, Giovanni Scandale, Gianni Carzaniga, Martino Recchia, Marzio Minola, Edoardo Perilli, Maria Carotta, Mariella Catalano
Pages: 102 - 103
The ankle-brachial index (ABI) is widely accepted as a diagnostic test used to evaluate the presence of peripheral arterial disease (PAD). 1. We investigated the associations between central arterial stiffness evaluated by measurement of aortic pulse wave velocity (aPWV), augmentation index (Aix) with...
Conference Abstract

P152 MICROALBUMINURIA IN NEWLY DIAGNOSED DIABETES MELLITUS: NOT ONLY ABOUT BLOOD PRESSURE OR ARTERIAL STIFFNESS

Barbara Nikolaidou, Eleni Gavriilaki, Eugene Gkaliagkousi, Ioanna Zografou, Areti Triantafyllou, Antonios Lazaridis, Stella Douma
Pages: 102 - 103
Background: Diabetes mellitus (DM) and hypertension (EH) are both associated with micro- and macro-vascular damage. Microalbuminuria is a recognized marker of sub-clinical target organ damage in both DM and EH. However, it’s determinants in newly diagnosed DM with or without EH remain unclear. Methods:...
Conference Abstract

P1.44 EARLY DETECTION OF ATHEROSCLEROTIC DISEASE IN MILD HYPERTENSIVE PATIENTS: A STRONG REASON TO REEVALUATE CARDIOVASCULAR RISK

P. Forcada, C. Kotliar, O. Montana, C. Schulte, G. Millet, S. Obregon, J. Guerrieri, D. Turri
Pages: 102 - 103
Conference Abstract

P1.45 GAMMA-GLUTAMYLTRANSFERASE - ANOTHER MARKER OF THE CARDIOVASCULAR RISK AND EARLY ARTERIAL DAMAGE?

M. Kovaite, L. Ryliskyte, Z. Petrulioniene, J. Badariene, V. Dzenkeviciute, A. Cypiene, A. Laucevicius
Pages: 103 - 103
Conference Abstract

P85 CEREBRAL SMALL VESSEL DISEASE AND RISK OF INCIDENT STROKE, DEMENTIA AND DEPRESSION, AND ALL-CAUSE MORTALITY: A SYSTEMATIC REVIEW AND META-ANALYSIS

Sytze Rensma, Thomas van Sloten, Lenore Launer, Coen Stehouwer
Pages: 103 - 103
Background: MRI features of cerebral small vessel disease, i.e. white matter hyperintensities, lacunes, microbleeds, perivascular spaces, and cerebral atrophy, may be associated with clinical events, but the strength of these associations remains unclear. Methods: We conducted a systematic review and...
Conference Abstract

P153 MARKER OF TYPE VI COLLAGEN FORMATION (PRO-C6) IS ASSOCIATED WITH HIGHER ARTERIAL STIFFNESS IN TYPE 1 DIABETES

Tine Willum Hansen, Daniel G.K. Rasmussen, Simone Theilade, Signe H. Nielsen, Morten A. Karsdal, Federica Genovese, Peter Rossing
Pages: 103 - 103
Aim: Arterial stiffening reflects fragmentation and loss of elastin fibers and accumulation of stiffer collagen fibers in the media of large arteries. We evaluated associations between carotid-femoral pulse wave velocity (cfPWV) and a marker of collagen type VI formation (Pro-C6) and a marker of collagen...
Review Article

Waves and Windkessels reviewed

Nicolaas Westerhof, Berend E. Westerhof
Pages: 102 - 111
Pressure and flow are travelling waves and are reflected at many locations. The forward and reflected waves, obtained by wave separation, are compound waves. This compounded character of the reflected wave explains why its magnitude decreases with increased peripheral resistance, why it appears to run...
Conference Abstract

P1.46 INTIMA-MEDIA THICKNESS VARIATION AS PREDICTOR OF ATHEROSCLEROSIS

I.M. Graf, F.H.B.M. Schreuder, J.M. Hameleers, W.H. Mess, R.S. Reneman, A.P.G. Hoeks
Pages: 103 - 103
Conference Abstract

P86 BLUNTED CEREBRAL MICROCIRCULATION OXYGENATION DURING EXERCISE IN NEWLY DIAGNOSED HYPERTENSIVE PATIENTS: LINKS WITH INDICES OF MACROCIRCULATION AND ARTERIAL STIFFNESS

Areti Triantafyllou, Konstantina Dipla, Nikolaos Koletsos, Alexandros-Savvas Zafeiridis, Stauros Papadopoulos, Iris Grigoriadou, Eugenia Gkaliagkousi, Andreas Zafeiridis, Stella Douma
Pages: 103 - 103
Purpose/Background/Objective: Hypertension has been considered as one of the most common modifiable risk factors for stroke and cognitive impairment. Decreased cerebral perfusion and oxygenation, as a result of capillary rarefaction and microvascular impairment of brain vessels, have been suggested as...
Conference Abstract

P154 VASCULAR STRUCTURE AND FUNCTION IN RELATION TO WEIGHT EXCESS AND BLOOD PRESSURE IN A SAMPLE OF OBESE CHILDREN

Sara Bonafini, Angela Tagetti, Francesco Dalle Vedove, Sara Raimondi, Alice Giontella, Paolo Cavarzere, Rossella Gaudino, Pietro Minuz, Claudio Maffeis, Franco Antoniazzi, Cristiano Fava
Pages: 103 - 103
Objective: To investigate the influence of weight excess and blood pressure (BP) on vascular structure and function in a sample of obese children. Methods: We measured office and ambulatory BP (ABPM), carotid intima-media thickness (cIMT), endothelial function by the Flow Mediated Dilation (FMD) technique,...
Research Article

Rationale and Design of a Randomized Controlled Trial to Evaluate the Effects of Probiotics during Energy Restriction on Blood Pressure, Body Composition, Metabolic Profile and Vascular Function in Obese Hypertensive Individuals

Marcella Rodrigues Guedes, Karine Scanci da Silva Pontes, Débora Cristina Torres Valença, Wille Oigman, Mario Fritsch Neves, Márcia Regina Simas Torres Klein
Pages: 102 - 110
Introduction: Hypertension often clusters with other cardiovascular risk factors such as obesity, dyslipidemia and glucose intolerance. Weight loss can decrease Blood Pressure (BP) and improve cardiometabolic abnormalities. There is evidence that hypertension and obesity are associated with alterations...
Conference Abstract

P87 CEREBROVASCULAR REACTIVITY DURING COGNITIVE ACTIVATION IN ADULTS WITH CONTROLLED HYPERTENSION

Wesley Lefferts, Jacob DeBlois, Tiago Barreira, Kevin Heffernan
Pages: 103 - 104
Hypertension, even when pharmaceutically controlled, may accelerate arterial stiffening and impair changes in blood flow necessary to support neural activity (neurovascular coupling [NVC]). Optimal NVC requires continuous, non-pulsatile flow, which is partially determined by extra- and intra-cranial...
Conference Abstract

P155 CORRELATION OF SOLUBLE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS AND S100-A1 ON ARTERIAL STIFFNESS IN NORMOTENSIVE PATIENTS WITH DIABETES

Patricia Quezada Fernandez, Fernando Grover Páez, Becerra Ramos, Carlos, Jhonatan Trujillo Quiros, Walter Trujillo Rangel, Sánchez Rodríguez Sánchez Rodríguez, David Cardona Müller, Mayra Jimenez Cázarez
Pages: 103 - 104
Background: Accumulation of advanced glycation end products (AGEs) are involved in several pathophysiological processes in the vessel wall, that may cause premature atherosclerosis and arterial stiffening (1). A soluble form of RAGE (sRAGE), which is a splice variant of full-length RAGE has been considered...
Conference Abstract

P1.49 EVALUATION OF ARTERIAL STIFFNESS AND CARDIOVASCULAR RISK STRATIFICATION IN A GENERAL POPULATION IN NORTHERN ITALY. THE VOBARNO STUDY

M. Salvetti, M.L. Muiesan, A. Paini, C. Monteduro, E. Belotti, C. Corbellini, G. Galbassini, C. Agabiti Rosei, L. Micheletti, C. Aggiusti, F. Marino, F. Bertacchini, Agabiti Rosei E
Pages: 103 - 104
Conference Abstract

P88 CENTRAL PRESSURE IN PATIENTS WITH ACUTE ISCHEMIC STROKE IN ACUTE PHASE: A PILOT STUDY

David Paiva, Ana Costa, Ana Luisa Campos, Filipa Gonçalves, Pedro Cunha, Jorge Cotter
Pages: 104 - 104
Acute Ischemic Stroke (AIS) is defined as sudden onset of a neurologic deficit. The main risk factor for stroke is high blood pressure (BP) and it is elevated in more than 70% or more of patients with AIS. In patients with AIS, management of blood pressure by brachial pressure is very important, but...
Conference Abstract

P156 DURATION OF DIABETES MELLITUS IS A SIGNIFICANT PREDICTOR OF ARTERIAL STIFFNESS IN PATIENTS WITH ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUS

Elena Troitskaya, Ekaterina Starostina, Zhanna Kobalava
Pages: 104 - 104
Background: Diabetic complications increase with disease duration but little is known about the relationships between aortic stiffness and diabetes duration. Aim: to assess associations of diabetes mellitus (DM) duration and parameters of arterial stiffness in patients with arterial hypertension (AH)...
Conference Abstract

P89 3 HOURS UNINTERRUPTED SITTING INCREASES CEREBROVASCULAR RESISTANCE AND REDUCES CEREBRAL BLOOD FLOW IN SUBJECTS WITH INCREASED CARDIOVASCULAR RISK

Yvonne Hartman
Pages: 104 - 104
Background: Sedentary behavior has deleterious effects on cardiovascular risk. Uninterrupted sitting is associated with an impaired peripheral blood flow and vascular function. However, the relation between cerebrovascular flow and sedentary behavior is currently unknown. Impaired cerebrovascular flow...
Conference Abstract

P157 RETINAL ARTERIOLAR FUNCTION, ENDOTHELIAL DYSFUNCTION AND ARTERIAL STIFFNESS IN PATIENTS WITH TYPE 2 DIABETES

Jonathan Baier, Søren Tang Knudsen, Line Petersen, Kristian Løkke Funck, Liv Vernstrøm Hald, Toke Bek, Per Løgstrup Poulsen, Esben Laugesen
Pages: 104 - 104
Background: Crosstalk between large and small arteries has been suggested to partake in the microvascular complication development in patients with type 2 diabetes mellitus (T2DM). Yet, data are scarce. In the present study, we aimed to elucidate the crosstalk between large and small arteries in T2DM. Methods:...
Short Communication

Bilateral lower extremity arterial thromboembolism mimicking conversion disorder

Umut Yucel Cavus, Mahmut Nedim Aytekin, Sema Avci, Macit Aydin, Mehmet Sait Dogan
Pages: 103 - 105
Thromboembolic causes of acute limb ischemia are not frequent; however, an immediate true therapy is needed to save the extremity. Here we presented a case with bilateral lower extremity arterial thromboembolism mimicking conversion disorder. Conversion disorder and acute arterial embolism can be confronted...
Conference Abstract

P1.52 REGULATION AND ACTIONS OF CARDIOTROPHIN-1 IN CULTURED RAT VASCULAR SMOOTH MUSCLE CELLS

N. Lopez-Andres, M.A. Fortuno, J. Nuée-Capiaumont, J. Diez, P. Lacolley, F. Zannad, P. Rossignol
Pages: 104 - 104
Research Article

Relationship between 24 h ambulatory central blood pressure and left ventricular mass – Rationale and design of a prospective multicenter study

Thomas Weber, Carmel McEniery, Ian Wilkinson, Giuseppe Schillaci, Maria Lorenza Muiesan, Robert Zweiker, Cristina Giannattasio, Kai Mortensen, Johannes Baulmann, Arno Schmidt-Trucksäss, Siegfried Wassertheurer
Pages: 103 - 108
The prognostic superiority of ambulatory over clinic blood pressure has been repeatedly proven. However, due to the mechanical properties of the arterial system, systolic and pulse pressures are higher in the brachial artery than in the ascending aorta. It seems logical that central pressures are more...
Conference Abstract

P90 KINETIC ENERGY AND ENERGY LOSS IN THE MIDDLE CEREBRAL ARTERY (MCA) OF HEARTMATE II PATIENTS

Koichi Akiyama, Ruiping Ji, Autumn Clemons, Francesco Castagna, Alberto Pinsino, John R. Cockcroft, Melana Yuzefpolsakaya, Reshad Garan, Hiroo Takayama, Koji Takeda, Yoshifumi Naka, Veli Topkara, Joshua Willey, Barry J. McDonnell, Paolo Colombo, Eric Stöhr
Pages: 104 - 105
Background: In heart failure patients with continuous-flow left ventricular assist devices (CF-LVAD), arterial pulsatility in the brain is reduced and diastolic blood velocities (Vmin) are maintained. The effects of such altered hemodynamics on kinetic energy and, importantly, energy loss in the cerebral...
Conference Abstract

P158 ASSOCIATION BETWEEN AMBULATORY ARTERIAL STIFFNESS INDEX, MARKERS OF BLOOD PRESSURE VARIABILITY AND INDICES OF SUBCLINICAL VASCULAR DAMAGE IN OBESE CHILDREN

Angela Tagetti, Sara Bonafini, Cristiano Fava
Pages: 104 - 105
Objective: Ambulatory Arterial Stiffness Index (AASI) and symmetric AASI (sAASI) have been proposed as indices of arterial stiffness obtained by 24-hour ambulatory blood pressure monitoring (ABPM). ABPM allows the analysis of indices of BP variability like day and night SD, BP dipping, weighted 24-h...
Conference Abstract

P1.54 THE RELATIONSHIP OF THE INSULIN-LIKE GROWTH FACTOR (IGF) SYSTEM TO CARDIOVASCULAR STRUCTURE AND FUNCTION IN WOMEN

M. Banerjee, K. Siddals, V. Charlton-Menys, M.J. Gibson, C. Austin, J.K. Cruickshank
Pages: 105 - 105
Conference Abstract

P91 THE EFFECTS OF DEVICE-GUIDED PACED BREATHING ON ARTERIAL STIFFNESS: IMPACT OF THE AUTONOMIC NERVOUS SYSTEM

Bushra Farukh, Luca Faconti, Phil J. Chowienczyk
Pages: 105 - 105
Objective: The autonomic nervous system (ANS) plays an important role in regulating blood pressure (BP), but its action on arterial stiffness (AS) is still debated. Here we examine if device-guided paced breathing (DGB) 1, via its action on ANS, can affect AS beyond its BP-lowering effect in hypertensive...
Conference Abstract

P159 ASSOCIATION BETWEEN PULSE WAVE VELOCITY AND APNEA-HYOPPNEA INDEX IN PATIENTS WITH TYPE 2 DIABETES AND OBSTRUCTIVE SLEEP APNEA

Christoffer Krogager, Anne Margereta Banghøj, Per Løgstrup Poulsen, Lise Tarnow, Esben Laugesen, Klavs Würgler Hansen
Pages: 105 - 105
Introduction: Obstructive sleep apnea (OSA) is associated with increased cardiovascular (CV) risk. OSA is highly prevalent among patients with type-2 diabetes (T2D). Patients with T2D have increased risk of cardiovascular events, and have an increased aortic stiffness. Continuous Positive Airway Pressure...
Conference Abstract

P1.55 INFLUENCE OF THE SOLUBLE CD14 ON AORTIC STIFFNESS USING A MENDELIAN RANDOMIZATION

L. Perez, J.B. Ruidavets, B. Chamontin, L. Drouet, J. Ferrieres, J. Amar
Pages: 105 - 105
Conference Abstract

P92 PARAMETERS FOR CENTRAL BLOOD PRESSURE AS PREDICTORS FOR THE EARLY CLINICAL AND FUNCTIONAL OUTCOME AFTER STROKE

Katrin Holzhauser
Pages: 105 - 105
Background: High mortality and the rate of patients who depend on care after survived stroke illustrate the importance of prevention and the importance of the development of predictors to identify patients with a high risk for an adverse progress of disease. The level of the arterial blood pressure depends...
Conference Abstract

P160 VASCULAR ABNORMALITIES AND HAEMODYNAMIC PATTERN IN OBESE YOUNG ADULTS

Pedro Forcada, Jorge Chiabaut Svane, Sergio Gonzalez, Carol Kotliar, Sebastian Obregon, Carlos Castellaro
Pages: 105 - 105
Background: Obesity is linked to a higher prevalence of risk factors, metabolic and inflammatory pathways conducting to increased vascular disease and CV risk. Objective: To assess vascular disarrangements and haemodynamic patterns in obese young subjects (O) compared with matched lean (L) controls,...
Conference Abstract

P93 RELATIONSHIP BETWEEN AORTIC PULSE WAVE VELOCITY AND MID CEREBRAL ARTERY PULSATILITY INDEX IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE; PILOT DATA FROM THE ARCADE STUDY

Mahfoudha Al Shezawi, John Cockcroft, Maggie Munnery, laura Watkeys, Nichola Gale, Barry McDonnell
Pages: 105 - 106
Background: Chronic obstructive pulmonary disease (COPD) is an inflammatory condition associated with increased cardiovascular risk. COPD patients have increased aortic stiffness and increased risk of stroke. In addition, increased mid cerebral artery pulsatility index (MCAPI) is associated with increased...
Conference Abstract

P161 ROLES OF ANGIOPOIETINS 1 AND 2 ON ARTERIAL FUNCTION DURING A TREATMENT TRIAL IN PEOPLE WITH OR AT RISK OF DIABETES

K. Parkin, G. Slee, R. Gray, A. Webb, C. Mills, J.K. Cruickshank
Pages: 105 - 105
Background/ Objective: Vascular growth factors angiopoietin-1 (Ang1) and -2 (Ang2) regulate vascular permeability and inflammation, Ang2 likely as Ang1’s selective antagonist. Their role before or in type 2 diabetes (pre-&T2D) is unknown. We hypothesised that higher circulating Ang1 and lower Ang2...
Research Article

Impact of human immunodeficiency virus infection on arterial stiffness and wave reflections in the early disease stages

Charalambos Vlachopoulos, Helen Sambatakou, Dimitris Tsiachris, Ilias Mariolis, Konstantinos Aznaouridis, Nikolaos Ioakeimidis, Athanasios J. Archimandritis, Christodoulos Stefanadis
Pages: 104 - 110
Background: Human immunodeficiency virus (HIV) infection is associated with subclinical inflammation and increased cardiovascular risk. Arterial stiffness and enhanced wave reflections are markers of cardiovascular disease and independent predictors of cardiovascular risk. The effect of HIV infection,...
Conference Abstract

P1.57 MODULATION OF ARGINASE IN RESPONSE TO WALL SHEAR STRESS

R.F. da Silva, V.C. Olivon, D. Segers, R. de Crom, R. Krams, N. Stergiopulos
Pages: 105 - 106
Conference Abstract

P182 ARTERIES IN PATIENTS WITH HUNTINGTON’S DISEASE

Ziva Melik, Jan Kobal, Ksenija Cankar, Janja Pretnar, Marjan Zaletel, Lucijan Kobal, Natasa Teran
Pages: 105 - 106
Background: Huntington’s disease (HD) is a neurodegenerative disorder leading to the progressive death of neurons in various brain regions. Although it is a disease of the central nervous system (CNS), mortality surveys indicate that heart disease is one of the mayor causes of death in HD patients. The...